Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2015 Volume 11 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2015 Volume 11 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Capsinoids suppress fat accumulation via lipid metabolism

  • Authors:
    • Qin Hong
    • Chen Xia
    • Hu Xiangying
    • Yuan Quan
  • View Affiliations / Copyright

    Affiliations: Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1669-1674
    |
    Published online on: November 24, 2014
       https://doi.org/10.3892/mmr.2014.2996
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Capsaicin, found in red peppers, has been reported to have anti‑obesity, anti‑hypertension, anti‑diabetes and anti‑inflammatory functions. In the present study, we determined the effect of non‑pungent capsinoids on the metabolism of adipocytes. We demonstrated that capsinoids suppressed fat accumulation in vivo and in vitro in mice. Liver, the main tissue of lipid metabolism, was treated by capsinoids, and HMG‑CoA reductase, CPT‑1, FAT/CD36 and GLUT4 were found to be increased significantly, which demonstrated promotion of the lipid metabolism in liver and adipose tissues. In addition, by adding capsinoids, the induced adipocytes also demonstrated significantly increased levels of HMG‑CoA reductase, CPT‑1, FAT/CD36 and GLUT4. Oil red O staining also demonstrated that capsinoids decreased fat accumulation in the adipocytes. In conclusion, these results indicate that capsinoids may be worth investigating as a potential cure for obesity.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Akpinar EK, Bicer Y and Yildiz C: Thin layer drying of red pepper. J Food Eng. 59:99–104. 2003. View Article : Google Scholar

2 

Kang JH, Goto T, Han IS, Kawada T, Kim YM and Yu R: Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet. Obesity (Silver Spring). 18:780–787. 2010. View Article : Google Scholar

3 

Szallasi A, Cortright DN, Blum CA and Eid SR: The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov. 6:357–372. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Dinis P, Charrua A, Avelino A, et al: The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate. Eur Urol. 48:162–167. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Chan CL, Facer P, Davis J, et al: Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet. 361:385–391. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Matias I, Gonthier MP, Petrosino S, et al: Role and regulation of acylethanolamides in energy balance: focus on adipocytes and β-cells. Br J Pharmacol. 152:676–690. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Diepvens K, Westerterp KR and Westerterp-Plantenga MS: Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol. 292:R77–R85. 2007. View Article : Google Scholar

8 

Uno K, Katagiri H, Yamada T, et al: Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science. 312:1656–1659. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Kang JH, Kim CS, Han IS, Kawada T and Yu R: Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Lett. 581:4389–4396. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Kang JH, Tsuyoshi G, Le Ngoc H, et al: Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice. J Med Food. 14:310–315. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Capsaicin Study Group. Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetes Care. 15:159–165. 1992. View Article : Google Scholar

12 

Yuen KC, Baker NR and Rayman G: Treatment of chronic painful diabetic neuropathy with isosorbide dinitrate spray a double-blind placebo-controlled cross-over study. Diabetes Care. 25:1699–1703. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Surh YJ and Lee SS: Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Food Chem Toxicol. 34:313–316. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Iida T, Moriyama T, Kobata K, et al: TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology. 44:958–967. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Tilg H and Moschen AR: Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 6:772–783. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Matsuzawa Y, Funahashi T and Nakamura T: Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann N Y Acad Sci. 892:146–154. 1999. View Article : Google Scholar

17 

Yamauchi T, Kamon J, Minokoshi Y, et al: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 8:1288–1295. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Posey KA, Clegg DJ, Printz RL, et al: Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab. 296:E1003–E1012. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Chawla A, Schwarz EJ, Dimaculangan DD and Lazar MA: Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology. 135:798–800. 1994.PubMed/NCBI

20 

Iwai K, Yazawa A and Watanabe T: Roles as metabolic regulators of the non-nutrients, capsaicin and capsiate, supplemented to diets. Proc Jpn Acad Ser B Phys Biol Sci. 79B:207–212. 2003. View Article : Google Scholar

21 

Ludy MJ, Moore GE and Mattes RD: The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses. 37:103–121. 2012. View Article : Google Scholar :

22 

Lee EJ, Jeon MS, Kim BD, et al: Capsiate inhibits ultraviolet B-induced skin inflammation by inhibiting Src family kinases and epidermal growth factor receptor signaling. Free Radic Biol Med. 48:1133–1143. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Haramizu S, Mizunoya W, Masuda Y, et al: Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors. Biosci Biotechnol Biochem. 70:774–781. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Nawrocki JW, Weiss SR, Davidson MH, et al: Reduction of LDL cholesterol by 25 to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol. 15:678–682. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Wanders R, Ferdinandusse S, Jansen G, et al: Peroxisomal fatty acid alpha-and beta-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases. Biochem Soc Trans. 29:250–267. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Brown MS and Goldstein JL: Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J Lipid Res. 21:505–517. 1980.PubMed/NCBI

27 

Coort SL, Willems J, Coumans WA, et al: Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake. Mol Cell Biochem. 239:213–219. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F and Kahn BB: Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem. 268:22243–22246. 1993.PubMed/NCBI

29 

Masuda Y, Haramizu S, Oki K, et al: Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. J Appl Physiol. 95:2408–2415. 2003.PubMed/NCBI

30 

Cannon B and Nedergaard J: Brown adipose tissue: function and physiological significance. Physiol Rev. 84:277–359. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Faraut B, Giannesini B, Matarazzo V, et al: Downregulation of uncoupling protein-3 in vivo is linked to changes in muscle mitochondrial energy metabolism as a result of capsiate administration. Am J Physiol Endocrinol Metab. 292:E1474–E1482. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hong Q, Xia C, Xiangying H and Quan Y: Capsinoids suppress fat accumulation via lipid metabolism. Mol Med Rep 11: 1669-1674, 2015.
APA
Hong, Q., Xia, C., Xiangying, H., & Quan, Y. (2015). Capsinoids suppress fat accumulation via lipid metabolism. Molecular Medicine Reports, 11, 1669-1674. https://doi.org/10.3892/mmr.2014.2996
MLA
Hong, Q., Xia, C., Xiangying, H., Quan, Y."Capsinoids suppress fat accumulation via lipid metabolism". Molecular Medicine Reports 11.3 (2015): 1669-1674.
Chicago
Hong, Q., Xia, C., Xiangying, H., Quan, Y."Capsinoids suppress fat accumulation via lipid metabolism". Molecular Medicine Reports 11, no. 3 (2015): 1669-1674. https://doi.org/10.3892/mmr.2014.2996
Copy and paste a formatted citation
x
Spandidos Publications style
Hong Q, Xia C, Xiangying H and Quan Y: Capsinoids suppress fat accumulation via lipid metabolism. Mol Med Rep 11: 1669-1674, 2015.
APA
Hong, Q., Xia, C., Xiangying, H., & Quan, Y. (2015). Capsinoids suppress fat accumulation via lipid metabolism. Molecular Medicine Reports, 11, 1669-1674. https://doi.org/10.3892/mmr.2014.2996
MLA
Hong, Q., Xia, C., Xiangying, H., Quan, Y."Capsinoids suppress fat accumulation via lipid metabolism". Molecular Medicine Reports 11.3 (2015): 1669-1674.
Chicago
Hong, Q., Xia, C., Xiangying, H., Quan, Y."Capsinoids suppress fat accumulation via lipid metabolism". Molecular Medicine Reports 11, no. 3 (2015): 1669-1674. https://doi.org/10.3892/mmr.2014.2996
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team