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Review Open Access

Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (Review)

  • Authors:
    • Jue Jiang
    • Hong Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3-12
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    Published online on: March 4, 2015
       https://doi.org/10.3892/mmr.2015.3424
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Abstract

The incidence of Alzheimer's disease (AD) in individuals >65 years of age is 13% and ~66 million individuals in this age group undergo surgery annually under anesthesia. It is therefore important to determine whether commonly used inhaled anesthetics induce cytotoxicity, which may lead to neurodegeneration. Findings from several studies suggest that the anesthetics, isoflurane, sevoflurane and desflurane, may activate caspases, increase the synthesis and accumulation of β‑amyloid (Aβ) protein, and induce hyperphosphorylation of tau proteins, all of which are cellular responses consistent with the neuropathogenesis of AD. Other studies have arrived at different and occasionally contradictory conclusions. The present review attempts to resolve this discrepancy by reviewing previous studies, which have investigated the effects of commonly used inhaled anesthetics on the synthesis and accumulation of Aβ, tau pathology and cognitive function. The possible underlying mechanism was also reviewed. However, several aspects of this phenomenon remain to be elucidated. Further studies are required to fully examine anesthesia‑induced neurotoxicity and elucidate the effect of inhaled anesthetics on the onset and progression of AD.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang J and Jiang H: Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (Review). Mol Med Rep 12: 3-12, 2015.
APA
Jiang, J., & Jiang, H. (2015). Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (Review). Molecular Medicine Reports, 12, 3-12. https://doi.org/10.3892/mmr.2015.3424
MLA
Jiang, J., Jiang, H."Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (Review)". Molecular Medicine Reports 12.1 (2015): 3-12.
Chicago
Jiang, J., Jiang, H."Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (Review)". Molecular Medicine Reports 12, no. 1 (2015): 3-12. https://doi.org/10.3892/mmr.2015.3424
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang J and Jiang H: Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (Review). Mol Med Rep 12: 3-12, 2015.
APA
Jiang, J., & Jiang, H. (2015). Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (Review). Molecular Medicine Reports, 12, 3-12. https://doi.org/10.3892/mmr.2015.3424
MLA
Jiang, J., Jiang, H."Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (Review)". Molecular Medicine Reports 12.1 (2015): 3-12.
Chicago
Jiang, J., Jiang, H."Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (Review)". Molecular Medicine Reports 12, no. 1 (2015): 3-12. https://doi.org/10.3892/mmr.2015.3424
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