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Article

Identification and function analysis of contrary genes in Dupuytren's contracture

  • Authors:
    • Xianglu Ji
    • Feng Tian
    • Lijie Tian
  • View Affiliations / Copyright

    Affiliations: Department of Hand and Foot Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110003, P.R. China
  • Pages: 482-488
    |
    Published online on: March 9, 2015
       https://doi.org/10.3892/mmr.2015.3458
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Abstract

The present study aimed to analyze the expression of genes involved in Dupuytren's contracture (DC), using bioinformatic methods. The profile of GSE21221 was downloaded from the gene expression ominibus, which included six samples, derived from fibroblasts and six healthy control samples, derived from carpal‑tunnel fibroblasts. A Distributed Intrusion Detection System was used in order to identify differentially expressed genes. The term contrary genes is proposed. Contrary genes were the genes that exhibited opposite expression pattterns in the positive and negative groups, and likely exhibited opposite functions. These were identified using Coexpress software. Gene ontology (GO) function analysis was conducted for the contrary genes. A network of GO terms was constructed using the reduce and visualize gene ontology database. Significantly expressed genes (801) and contrary genes (98) were screened. A significant association was observed between Chitinase‑3‑like protein 1 and ten genes in the positive gene set. Positive regulation of transcription and the activation of nuclear factor‑κB (NF‑κB)‑inducing kinase activity exhibited the highest degree values in the network of GO terms. In the present study, the expression of genes involved in the development of DC was analyzed, and the concept of contrary genes proposed. The genes identified in the present study are involved in the positive regulation of transcription and activation of NF‑κB‑inducing kinase activity. The contrary genes and GO terms identified in the present study may potentially be used for DC diagnosis and treatment.
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1 

Murphey MD, Ruble CM, Tyszko SM, Zbojniewicz AM, Potter BK and Miettinen M: From the archines of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 29:2143–2173. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Van Rijssen A and Werker P: Percutaneous needle fasciotomy in dupuytren’s disease. J Hand Surg Br. 31:498–501. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Reilly RM, Stern PJ and Goldfarb CA: A retrospective review of the management of Dupuytren’s nodules. J Hand Surg Am. 30:1014–1018. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Loos B, Puschkin V and Horch RE: 50 years experience with Dupuytren’s contracture in the Erlangen University Hospital - a retrospective analysis of 2919 operated hands from 1956 to 2006. BMC Musculoskelet Disord. 8:602007. View Article : Google Scholar

5 

Hurst LC and Badalamente MA: Nonoperative treatment of Dupuytren’s disease. Hand Clin. 15:97–107. 1999.

6 

Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 71:1397–1421. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Shimokawa H and Takeshita A: Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol. 25:1767–1775. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Cordova A, Tripoli M, Corradino B, Napoli P and Moschella F: Dupuytren’s contracture: an update of biomolecular aspects and therapeutic perspectives. Journ Hand Surg Br. 30:557–562. 2005. View Article : Google Scholar

9 

Satish L, LaFramboise WA, O’Gorman DB, et al: Identification of differentially expressed genes in fibroblasts derived from patients with Dupuytren’s Contracture. BMC Med Genomics. 1:102008. View Article : Google Scholar

10 

Mosakhani N, Guled M, Lahti L, et al: Unique microRNA profile in Dupuytren’s contracture supports deregulation of β-catenin pathway. Mod Pathol. 23:1544–1552. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Lee LC, Zhang AY, Chong AK, Pham H, Longaker MT and Chang J: Expression of a novel gene, MafB, in Dupuytren’s disease. J Hand Surg Am. 31:211–218. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Johnston P, Larson D, Clark IM and Chojnowski AJ: Metalloproteinase gene expression correlates with clinical outcome in Dupuytren’s disease. J Hand Surg Am. 33:1160–1167. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Snapp SR, Brentano J, Dias GV, et al: DIDS (distributed intrusion detection system)-motivation, architecture, and an early prototype. Proceedings of the 14th National Computer Security Conference Washington, DC, USA: Epstein J and Picciotto J: http://citeseeristpsu.edu/snapp91didshtmlurisimpleciteseeristpsu.edu/snapp91didshtml. pp. 167–176. 1991

14 

Page RD: Visualizing phylogenetic trees using TreeView. Curr Protoc Bioinformatics. 6:Unit 6.2. 2002. View Article : Google Scholar

15 

Yang JH, Li JH, Shao P, Zhou H, Chen YQ and Qu LH: starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res. 39:D202–D209. 2011. View Article : Google Scholar

16 

Rebhan M, Chalifa-Caspi V, Prilusky J and Lancet D: GeneCards: a novel functional genomics compendium with automated data mining and query reformulation support. Bioinformatics. 14:656–664. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Supek F, Bošnjak M, Škunca N and Šmuc T: REVIGO summarizes and visualizes long lists of gene ontology terms. PloS One. 6:e218002011. View Article : Google Scholar : PubMed/NCBI

18 

Zhang L and Hermanns H: Deciding simulations on probabilistic automata. Automated Technology for Verification and Analysis (ATVA), 5th International Symposium. Namjoshi KS, et al: Springer-Verlag; Heidelberg: pp. 207–222. 2007, View Article : Google Scholar

19 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar :

20 

Saito R, Smoot ME, Ono K, et al: A travel guide to Cytoscape plugins. Nat Methods. 9:1069–1076. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Forrester HB, Temple-Smith P, Ham S, de Kretser D, Southwick G and Sprung CN: Genome-wide analysis using exon arrays demonstrates an important role for expression of extra-cellular matrix, fibrotic control and tissue remodelling genes in Dupuytren’s disease. PLoS One. 8:e590562013. View Article : Google Scholar

22 

Recklies AD, Ling H, White C and Bernier SM: Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. J Biol Chem. 280:41213–41221. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Baird KS, Crossan JF and Ralston SN: Abnormal growth factor and cytokine expression in Dupuytren’s contracture. J Clin Pathol. 46:425–428. 1993. View Article : Google Scholar : PubMed/NCBI

24 

Wang L, Lawrence MS, Wan Y, et al: SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 365:2497–2506. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Saw C, Wu Q and Kong A: Anti-cancer and potential chemo-preventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways. Chin Med. 5:372010. View Article : Google Scholar

26 

Veeranki S, Duan X, Panchanathan R, Liu H and Choubey D: IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. PLoS One. 6:e270402011. View Article : Google Scholar : PubMed/NCBI

27 

Liao G, Cheung S, Galeano J, Ji AX, Qin Q and Bi X: Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1−/− mouse brain. Brain Res. 1270:140–151. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Kurtz KM and Breslin JW: Rnd3 accelerates termination of thrombin-induced Rho activation in endothelial cells. FASEB J. Meeting Abstract Suppl. 762.142009.

29 

Wang HW, Lin CP, Chiu JH, et al: Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. Int J Cancer. 120:2019–2027. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Bayat A, Watson JS, Stanley JK, Ferguson MW and Ollier WE: Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene. Plast Reconstr Surg. 111:2133–2139. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Verjee LS, Midwood K, Davidson D, Eastwood M and Nanchahal J: Post-transcriptional regulation of alpha-smooth muscle actin determines the contractile phenotype of Dupuytren’s nodular cells. J Cell Physiol. 224:681–690. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ji X, Tian F and Tian L: Identification and function analysis of contrary genes in Dupuytren's contracture. Mol Med Rep 12: 482-488, 2015.
APA
Ji, X., Tian, F., & Tian, L. (2015). Identification and function analysis of contrary genes in Dupuytren's contracture. Molecular Medicine Reports, 12, 482-488. https://doi.org/10.3892/mmr.2015.3458
MLA
Ji, X., Tian, F., Tian, L."Identification and function analysis of contrary genes in Dupuytren's contracture". Molecular Medicine Reports 12.1 (2015): 482-488.
Chicago
Ji, X., Tian, F., Tian, L."Identification and function analysis of contrary genes in Dupuytren's contracture". Molecular Medicine Reports 12, no. 1 (2015): 482-488. https://doi.org/10.3892/mmr.2015.3458
Copy and paste a formatted citation
x
Spandidos Publications style
Ji X, Tian F and Tian L: Identification and function analysis of contrary genes in Dupuytren's contracture. Mol Med Rep 12: 482-488, 2015.
APA
Ji, X., Tian, F., & Tian, L. (2015). Identification and function analysis of contrary genes in Dupuytren's contracture. Molecular Medicine Reports, 12, 482-488. https://doi.org/10.3892/mmr.2015.3458
MLA
Ji, X., Tian, F., Tian, L."Identification and function analysis of contrary genes in Dupuytren's contracture". Molecular Medicine Reports 12.1 (2015): 482-488.
Chicago
Ji, X., Tian, F., Tian, L."Identification and function analysis of contrary genes in Dupuytren's contracture". Molecular Medicine Reports 12, no. 1 (2015): 482-488. https://doi.org/10.3892/mmr.2015.3458
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