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Resveratrol analog piceatannol restores the palmitic acid‑induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti‑inflammatory and antioxidative heme oxygenase‑1 in human endothelial cells

  • Authors:
    • Sun‑Oh Jeong
    • Yong Son
    • Ju Hwan Lee
    • Yong‑Kwan Cheong
    • Seong Hoon Park
    • Hun‑Taeg Chung
    • Hyun‑Ock Pae
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan 570‑749, Republic of Korea, Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Iksan 570‑749, Republic of Korea, Institute for Metabolic Disease, Wonkwang University School of Medicine, Iksan 570‑749, Republic of Korea, Department of Biological Science, University of Ulsan, Ulsan 680‑749, Republic of Korea
    Copyright: © Jeong et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 937-944
    |
    Published online on: March 26, 2015
       https://doi.org/10.3892/mmr.2015.3553
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Abstract

Growing evidence suggests that the elevation of free fatty acids, including palmitic acid (PA), are associated with inflammation and oxidative stress, which may be involved in endothelial dysfunction, characterized by the reduced bioavailability of nitric oxide (NO) synthesized from endothelial NO synthase (eNOS). Heme oxygenase‑1 (HO‑1) is important in the preservation of NO bioavailability. Piceatannol (Pic), with similar chemical structure to resveratrol, is suggested to possess similar protective effects as resveratrol. In the present study, human umbilical vein endothelial cells (HUVECs), stimulated with PA, were used to examine the endothelial protective effects of Pic. Pic increased the expression of HO‑1 via nuclear factor erythroid‑2‑related factor‑2 activation in the HUVECs, and decreased the PA‑induced secretions of interleukin‑6 and tumor necrosis factor‑α, and the formation of reactive oxygen species ROS via inhibition of NF‑κB activation. Notably, following inhibition of HO‑1 activity by tin protoporphryin‑IX, Pic did not prevent cytokine secretion, ROS formation, and NF‑κB activation in the PA‑stimulated HUVECs. PA attenuated insulin‑mediated insulin receptor substrate‑1 (IRS‑1) tyrosine phosphorylation, leading to decreased glucose uptake, and phosphorylation of eNOS, leading to a reduction in the production of NO. Pic effectively mitigated the inhibitory effects of PA on the insulin‑mediated phosphorylation of IRS‑1 and eNOS, which was not observed following inhibition of HO‑1 activity. The results of the present study suggested that Pic may have the potential to prevent PA‑induced impairment of insulin signaling and eNOS function, by inducing the expression of the anti‑inflammatory and antioxidant, HO‑1.
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1 

Tousoulis D, Papageorgiou N, Androulakis E, et al: Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches. J Am Coll Cardiol. 62:667–676. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Capurso C and Capurso A: From excess adiposity to insulin resistance: the role of free fatty acids. Vascul Pharmacol. 57:91–97. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Maloney E, Sweet IR, Hockenbery DM, et al: Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arterioscler Thromb Vasc Biol. 29:1370–1375. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Kim F, Tysseling KA, Rice J, et al: Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol. 25:989–994. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Knopp RH, Retzlaff B, Walden C, Fish B, Buck B and McCann B: One-year effects of increasingly fat-restricted, carbohydrate-enriched diets on lipoprotein levels in free-living subjects. Proc Soc Exp Biol Med. 225:191–199. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Yli-Jama P, Meyer HE, Ringstad J and Pedersen JI: Serum free fatty acid pattern and risk of myocardial infarction: a case-control study. J Intern Med. 251:19–28. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Liu K, Zhao W, Gao X, Huang F, Kou J and Liu B: Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways. Atherosclerosis. 223:350–358. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Pae HO, Son Y, Kim NH, Jeong HJ, Chang KC and Chung HT: Role of heme oxygenase in preserving vascular bioactive NO. Nitric Oxide. 23:251–257. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Kim YM, Pae HO, Park JE, et al: Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 14:137–167. 2011. View Article : Google Scholar :

10 

Pae HO, Kim EC and Chung HT: Integrative survival response evoked by heme oxygenase-1 and heme metabolites. J Clin Biochem Nutr. 42:197–203. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Piotrowska H, Kucinska M and Murias M: Biological activity of piceatannol: leaving the shadow of resveratrol. Mutat Res. 750:60–82. 2012. View Article : Google Scholar

12 

Szekeres T, Saiko P, Fritzer-Szekeres M, Djavan B and Jäger W: Chemopreventive effects of resveratrol and resveratrol derivatives. Ann N Y Acad Sci. 1215:89–95. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Kim SW, Kim CE and Kim MH: Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells. Biochem Biophys Res Commun. 415:602–607. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Xu Q, Hao X, Yang Q and Si L: Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase. Biochem Biophys Res Commun. 388:389–394. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Yu HP, Hwang TL, Hwang TL, Yen CH and Lau YT: Resveratrol prevents endothelial dysfunction and aortic superoxide production after trauma hemorrhage through estrogen receptor-dependent hemeoxygenase-1 pathway. Crit Care Med. 38:1147–1154. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Becker JC, Grosser N, Waltke C, et al: Beyond gastric acid reduction: proton pump inhibitors induce heme oxygenase-1 in gastric and endothelial cells. Biochem Biophys Res Commun. 345:1014–1021. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Moon B, Kwan JJ, Duddy N, Sweeney G and Begum N: Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation. Am J Physiol Endocrinol Metab. 285:E106–E115. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Guo XD, Zhang DY, Gao XJ, et al: Quercetin and quer-cetin-3-O-glucuronide are equally effective in ameliorating endolthelial insulin resistance through inhibition of reactive oxygen species-associated inflammation. Mol Nutr Food Res. 57:1037–1045. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Prieto D, Contreras C and Sánchez A: Endothelial dysfunction, obesity and insulin resistance. Curr Vasc Pharmacol. 12:412–426. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Son Y, Byun SJ and Pae HO: Involvement of heme oxygenase-1 expression in neuroprotection by piceatannol, a natural analog and a metabolite of resveratrol, against glutamate-mediated oxidative injury in HT22 neuronal cells. Amino Acids. 45:393–401. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Lee HH, Park SA, Almazari I, Kim EH, Na HK and Surh YJ: Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling. Arch Biochem Biophys. 501:142–150. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Son Y, Chung HT and Pae HO: Differential effects of resveratrol and its natural analogs, piceatannol and 3,5,4′-trans-trimethoxys-tilbene, on anti-inflammatory heme oxigenase-1 expression in RAW264.7 macrophages. Biofactors. 40:138–145. 2014. View Article : Google Scholar

23 

Wung BS, Hsu MC, Wu CC and Hsieh CW: Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. Pharmacol Res. 53:113–122. 2006. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Jeong SO, Son Y, Lee JH, Cheong YK, Park SH, Chung HT and Pae HO: Resveratrol analog piceatannol restores the palmitic acid‑induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti‑inflammatory and antioxidative heme oxygenase‑1 in human endothelial cells. Mol Med Rep 12: 937-944, 2015.
APA
Jeong, S., Son, Y., Lee, J.H., Cheong, Y., Park, S.H., Chung, H., & Pae, H. (2015). Resveratrol analog piceatannol restores the palmitic acid‑induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti‑inflammatory and antioxidative heme oxygenase‑1 in human endothelial cells. Molecular Medicine Reports, 12, 937-944. https://doi.org/10.3892/mmr.2015.3553
MLA
Jeong, S., Son, Y., Lee, J. H., Cheong, Y., Park, S. H., Chung, H., Pae, H."Resveratrol analog piceatannol restores the palmitic acid‑induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti‑inflammatory and antioxidative heme oxygenase‑1 in human endothelial cells". Molecular Medicine Reports 12.1 (2015): 937-944.
Chicago
Jeong, S., Son, Y., Lee, J. H., Cheong, Y., Park, S. H., Chung, H., Pae, H."Resveratrol analog piceatannol restores the palmitic acid‑induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti‑inflammatory and antioxidative heme oxygenase‑1 in human endothelial cells". Molecular Medicine Reports 12, no. 1 (2015): 937-944. https://doi.org/10.3892/mmr.2015.3553
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong SO, Son Y, Lee JH, Cheong YK, Park SH, Chung HT and Pae HO: Resveratrol analog piceatannol restores the palmitic acid‑induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti‑inflammatory and antioxidative heme oxygenase‑1 in human endothelial cells. Mol Med Rep 12: 937-944, 2015.
APA
Jeong, S., Son, Y., Lee, J.H., Cheong, Y., Park, S.H., Chung, H., & Pae, H. (2015). Resveratrol analog piceatannol restores the palmitic acid‑induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti‑inflammatory and antioxidative heme oxygenase‑1 in human endothelial cells. Molecular Medicine Reports, 12, 937-944. https://doi.org/10.3892/mmr.2015.3553
MLA
Jeong, S., Son, Y., Lee, J. H., Cheong, Y., Park, S. H., Chung, H., Pae, H."Resveratrol analog piceatannol restores the palmitic acid‑induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti‑inflammatory and antioxidative heme oxygenase‑1 in human endothelial cells". Molecular Medicine Reports 12.1 (2015): 937-944.
Chicago
Jeong, S., Son, Y., Lee, J. H., Cheong, Y., Park, S. H., Chung, H., Pae, H."Resveratrol analog piceatannol restores the palmitic acid‑induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti‑inflammatory and antioxidative heme oxygenase‑1 in human endothelial cells". Molecular Medicine Reports 12, no. 1 (2015): 937-944. https://doi.org/10.3892/mmr.2015.3553
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