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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-2015 Volume 12 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy

  • Authors:
    • Huiling Li
    • Jianxing He
    • Nanshan Zhong
    • Robert M. Hoffman

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory, Hainan Branch of PLA Hospital, Sanya, Hainan 572000, P.R. China, Department of Surgery, University of California, San Diego, CA 92111, USA
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3236-3242
    |
    Published online on: May 25, 2015
       https://doi.org/10.3892/mmr.2015.3837
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Abstract

The Am1010 cell line was previously established from a metastatic deposit in an arm muscle from a patient with lung adenocarcinoma who had undergone four cycles of chemotherapy with cisplatin and taxol. Am1010 cells were labeled with red fluorescent protein or green fluorescent protein. A total of eight sublines were isolated following in vitro exposure to cisplatin or taxol. The sublines differed with regard to their adhesion and proliferation properties, with certain sublines exhibiting an increased proliferation rate and/or decreased surface adhesion. Gene expression assays demonstrated that tenascin C; cyclin D1; collagen, type 1, α2; integrin α1; related RAS viral (r‑ras) oncogene homolog 2; platelet‑derived growth factor C; and Src homolog 2 domain containing in the focal adhesion pathway, and intercellular adhesion molecule 1, F11 receptor, claudin 7 and cadherin 1 in the cell adhesion pathway, varied in expression among the sublines. The results of the present study suggested that drug exposure may alter the aggressiveness and metastatic potential of cancer cells, which has important implications for cancer chemotherapy.
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1 

Levina V, Marrangoni AM, DeMarco R, Gorelik E and Lokshin AE: Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties. PLoS One. 3:e30772008. View Article : Google Scholar : PubMed/NCBI

2 

Nadkar A, Pungaliya C, Drake K, Zajac E, Singhal SS and Awasthi S: Therapeutic resistance in lung cancer. Expert Opin Drug Metab Toxicol. 2:753–777. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Peacock CD and Watkins DN: Cancer stem cells and the ontogeny of lung cancer. J Clin Oncol. 26:2883–2889. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Tysnes BB and Bjerkvig R: Cancer initiation and progression: involvement of stem cells and the microenvironment. Biochim Biophys Acta. 1775:283–297. 2007.PubMed/NCBI

5 

Li HL, Xie SM, Zhang L, et al: Establishment and characterization of a new drug surviving cell line Am1010, derived directly from muscle metastases of a human lung adenocarcinoma patient with multi-drug-resistance to cisplatin, taxol and gefitinib. Acta Pharmacol Sin. 31:601–608. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Hoffman RM and Yang M: Color-coded fluorescence imaging of tumor-host interactions. Nat Protoc. 1:928–935. 2006. View Article : Google Scholar

7 

Alamgeer M, Peacock CD, Matsui W, Ganju V and Watkins DN: Cancer stem cells in lung cancer: Evdence and controversies. Respirology. 18:757–764. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li H, He J, Zhong N and Hoffman RM: Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy. Mol Med Rep 12: 3236-3242, 2015.
APA
Li, H., He, J., Zhong, N., & Hoffman, R.M. (2015). Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy. Molecular Medicine Reports, 12, 3236-3242. https://doi.org/10.3892/mmr.2015.3837
MLA
Li, H., He, J., Zhong, N., Hoffman, R. M."Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy". Molecular Medicine Reports 12.3 (2015): 3236-3242.
Chicago
Li, H., He, J., Zhong, N., Hoffman, R. M."Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy". Molecular Medicine Reports 12, no. 3 (2015): 3236-3242. https://doi.org/10.3892/mmr.2015.3837
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, He J, Zhong N and Hoffman RM: Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy. Mol Med Rep 12: 3236-3242, 2015.
APA
Li, H., He, J., Zhong, N., & Hoffman, R.M. (2015). Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy. Molecular Medicine Reports, 12, 3236-3242. https://doi.org/10.3892/mmr.2015.3837
MLA
Li, H., He, J., Zhong, N., Hoffman, R. M."Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy". Molecular Medicine Reports 12.3 (2015): 3236-3242.
Chicago
Li, H., He, J., Zhong, N., Hoffman, R. M."Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy". Molecular Medicine Reports 12, no. 3 (2015): 3236-3242. https://doi.org/10.3892/mmr.2015.3837
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