MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells

Zhu,Liang; Liu,Rong; Zhang,Wei; Qian,Sheng; Wang,Jian‑Hua

doi:10.3892/mmr.2015.3998

September-2015 Volume 12 Issue 3

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September-2015 Volume 12 Issue 3

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Article

MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells

Authors:
- Liang Zhu
- Rong Liu
- Wei Zhang
- Sheng Qian
- Jian‑Hua Wang
View Affiliations / Copyright

Affiliations: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
Pages: 4652-4656
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Published online on: June 25, 2015

https://doi.org/10.3892/mmr.2015.3998
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Abstract

Ubiquitin specific peptidase 7 (UPS7) has a critical role in the development and progression of cancer, at least in part, through its regulation of p53 protein stability. However, its molecular determinants remain to be elucidated. In the present study, it was identified that microRNA‑205 (miR‑205) may negatively regulate UPS7 protein levels through targeting its 3'‑untranslated region in hepatocellular carcinoma (HCC) cells. As a result, miR‑205 mimics inhibited USP7 protein levels while antisense miR‑205 enhanced USP7 protein levels, thereby modulating the p53 signaling pathway and cell proliferation levels. In conclusion, the data presents a novel molecule for the dysregulated expression of USP7 in HCC, which may assist in elucidating mechanisms underlying the tumorigenesis of HCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells

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Abstract

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