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Article

Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis

  • Authors:
    • Hongbin Jiang
    • Jun Zhang
    • Zhemin Zhang
    • Shengxiang Ren
    • Chuansen Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Second Military Medical University, Shanghai 200433, P.R. China, Department of Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China, Department of Respiratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China, Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China
  • Pages: 5933-5938
    |
    Published online on: August 5, 2015
       https://doi.org/10.3892/mmr.2015.4178
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Abstract

Stem cell‑based cell therapy has provided a promising method for the treatment of pulmonary diseases, including idiopathic pulmonary fibrosis (IPF). Furthermore, adipose‑derived stem cells (ADSCs) have been reported to be effective in lung repair and regeneration. In the current study, IPF was induced in mice by intratracheal instillation of bleomycin (BLM), and ADSCs were delivered systemically into the mice via the tail vein to evaluate the effects of ADSC transplantation. The ADSC engraftment rate and morphometric changes in lung tissue samples in vivo were investigated by histochemistry and immunohistochemistry, as well as by western blotting. The results indicated that ADSCs may relieve IPF and provide a significant contribution to lung repair when administered at an early stage.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang H, Zhang J, Zhang Z, Ren S and Zhang C: Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis. Mol Med Rep 12: 5933-5938, 2015.
APA
Jiang, H., Zhang, J., Zhang, Z., Ren, S., & Zhang, C. (2015). Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis. Molecular Medicine Reports, 12, 5933-5938. https://doi.org/10.3892/mmr.2015.4178
MLA
Jiang, H., Zhang, J., Zhang, Z., Ren, S., Zhang, C."Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis". Molecular Medicine Reports 12.4 (2015): 5933-5938.
Chicago
Jiang, H., Zhang, J., Zhang, Z., Ren, S., Zhang, C."Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis". Molecular Medicine Reports 12, no. 4 (2015): 5933-5938. https://doi.org/10.3892/mmr.2015.4178
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang H, Zhang J, Zhang Z, Ren S and Zhang C: Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis. Mol Med Rep 12: 5933-5938, 2015.
APA
Jiang, H., Zhang, J., Zhang, Z., Ren, S., & Zhang, C. (2015). Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis. Molecular Medicine Reports, 12, 5933-5938. https://doi.org/10.3892/mmr.2015.4178
MLA
Jiang, H., Zhang, J., Zhang, Z., Ren, S., Zhang, C."Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis". Molecular Medicine Reports 12.4 (2015): 5933-5938.
Chicago
Jiang, H., Zhang, J., Zhang, Z., Ren, S., Zhang, C."Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis". Molecular Medicine Reports 12, no. 4 (2015): 5933-5938. https://doi.org/10.3892/mmr.2015.4178
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