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Review

Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)

  • Authors:
    • Junrong Zou
    • Pei Guo
    • Nonghua Lv
    • Deqiang Huang
  • View Affiliations / Copyright

    Affiliations: Research Institute of Digestive Diseases, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 6399-6404
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    Published online on: August 25, 2015
       https://doi.org/10.3892/mmr.2015.4243
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Abstract

Lipopolysaccharide-induced tumor necrosis factor-α factor (LITAF) exerts transcription factor activity and is involved in protein quality control. LITAF activity is highly dependent on correct translocation from the endosome/lysosome to the nucleus, while certain LITAF mutants mislocalize to areas, such as the cytosol and mitochondria, resulting in developmental diseases. In addition, previous studies have proposed that LITAF functions as a tumor suppressor and is frequently under‑represented in certain types of cancer. However, the mechanism of this phenomenon remains unclear. The present review summarizes the major advances in LITAF studies, and proposes that LITAF may serve as a switch in the balance between classical and alternative activation in tumor associated‑inflammation. Thus, LITAF may be a promising therapeutic target with regard to the tumor microenvironment.
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1 

Polyak K, Xia Y, Zweier JL, Kinzler KW and Vogelstein B: A model for p53-induced apoptosis. Nature. 389:300–305. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Myokai F, Takashiba S, Lebo R and Amar S: A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: Molecular cloning, sequencing, characterization and chromosomal assignment. Proc Natl Acad Sci USA. 96:4518–4523. 1999. View Article : Google Scholar

3 

Tang X, Marciano DL, Leeman SE and Amar S: LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor and STAT6 (B) with effects on multiple cytokines. Proc Natl Acad Sci USA. 102:5132–5137. 2005. View Article : Google Scholar

4 

Tang X, Metzger D, Leeman S and Amar S: LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci USA. 103:13777–13782. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Mantovani A: Cancer: Inflaming metastasis. Nature. 457:36–37. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Gocheva V, Wang H-W, Gadea BB, Shree T, Hunter KE, Garfall AL, Berman T and Joyce JA: IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 24:241–255. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Chen J, Yao Y, Gong C, Yu F, Su S, Chen J, Liu B, Deng H, Wang F, Lin L, et al: CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell. 19:541–555. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Su S, Liu Q, Chen J, Chen J, Chen F, He C, Huang D, Wu W, Lin L, Huang W, et al: A Positive Feedback Loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer cell. 25:605–620. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Bolcato-Bellemin AL, Mattei MG, Fenton M and Amar S: Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression. J Endotoxin Res. 10:15–23. 2004.PubMed/NCBI

11 

Moriwaki Y, Begum NA, Kobayashi M, Matsumoto M, Toyoshima K and Seya T: Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1. J Biol Chem. 276:23065–23076. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Boge M, Wyss S, Bonifacino JS and Thali M: A membrane-proximal tyrosine-based signal mediates internalization of the HIV-1 envelope glycoprotein via interaction with the AP-2 clathrin adaptor. J Biol Chem. 273:15773–15778. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Bonifacino JS and Dell'Angelica EC: Molecular bases for the recognition of tyrosine-based sorting signals. J Cell Biol. 145:923–926. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Simmen T, Schmidt A, Hunziker W and Beermann F: The tyrosinase tail mediates sorting to the lysosomal compartment in MDCK cells via a di-leucine and a tyrosine-based signal. J Cell Sci. 112:45–53. 1999.

15 

Letourneur F and Klausner RD: A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell. 69:1143–1157. 1992. View Article : Google Scholar : PubMed/NCBI

16 

Shirk AJ, Anderson SK, Hashemi SH, Chance PF and Bennett CL: SIMPLE interacts with NEDD4 and TSG101: Evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. J Neurosci Res. 82:43–50. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Lee SM, Chin LS and Li L: Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking. J Cell Biol. 199:799–816. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lee SM, Olzmann JA, Chin LS and Li L: Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. J Cell Sci. 124:3319–3331. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Ferreira Lacerda AF, Hartjes E and Brunetti CR: LITAF mutations associated with Charcot-Marie-Tooth Disease 1C Show mislocalization from the late endosome/lysosome to the mitochondria. PLoS One. 9:e1034542014. View Article : Google Scholar :

20 

Ciotti P, Luigetti M, Geroldi A, Capponi S, Pezzini I, Gulli R, Pazzaglia C, Padua L, Massa R, Mandich P, et al: A novel LITAF/SIMPLE mutation within a family with a demyelinating form of Charcot-Marie-Tooth disease. J Neurol Sci. 343:183–186. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Luigetti M, Fabrizi GM, Taioli F, Del Grande A and Lo Monaco M: A novel LITAF/SIMPLE variant within a family with minimal demyelinating Charcot-Marie-Tooth disease. Neurol Sci. 35:2014. View Article : Google Scholar : PubMed/NCBI

22 

Tang X, Molina M and Amar S: p53 short peptide (p53pep164) regulates lipopolysaccharide-induced tumor necrosis factor-alpha factor/cytokine expression. Cancer Res. 67:1308–1316. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Tang X, Woodward T and Amar S: A PTP4A3 peptide PIMAP39 modulates TNF-alpha levels and endotoxic shock. J Innate Immun. 2:43–55. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Brannigan AE, Watson RW, Beddy D, Hurley H, Fitzpatrick JM and O'Connell PR: Increased adhesion molecule expression in serosal fibroblasts isolated from patients with inflammatory bowel disease is secondary to inflammation. Ann Surg. 235:507–511. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Matsuno H, Yudoh K, Katayama R, Nakazawa F, Uzuki M, Sawai T, Yonezawa T, Saeki Y, Panayi GS, Pitzalis C, et al: The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): A study using a human RA/SCID mouse chimera. Rheumatology (Oxford). 41:329–337. 2002. View Article : Google Scholar

26 

Stucchi A, Reed K, O'Brien M, Cerda S, Andrews C, Gower A, Bushell K, Amar S, Leeman S and Becker J: A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis. 12:581–587. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Baker DA, Barth J, Chang R, Obeid LM and Gilkeson GS: Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. J Immunol. 185:2570–2579. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Bushell KN, Leeman SE, Gillespie E, Gower AC, Reed KL, Stucchi AF, Becker JM and Amar S: LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages. PLoS One. 6:e258492011. View Article : Google Scholar

29 

Stucchi A, Reed K, O'Brien M, Cerda S, Andrews C, Gower A, Bushell K, Amar S, Leeman S and Becker J: A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis. 12:581–587. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Bushell KN, Leeman SE, Amar S, Reed KL, Gower AC, Stucchi AF and Becker JM: Macrophage-specific LITAF (lipopolysaccharide induced TNF-alpha factor) knockout mice (LITAF mac−/−) have a reduced inflammatory response to colonic administration of trinitrobenzene sulfonic acid (TNBS). FASEB J. 22(Meeting Abstract Supplement): 1138.42008.

31 

Zhang H, Hilton MJ, Anolik JH, Welle SL, Zhao C, Yao Z, Li X, Wang Z, Boyce BF and Xing L: NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB. J Clin Invest. 124:3200–3214. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Feldmann M, Brennan FM and Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol. 14:397–440. 1996. View Article : Google Scholar : PubMed/NCBI

33 

Brennan FM and McInnes IB: Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest. 118:3537–3545. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Merrill JC, You J, Constable C, Leeman SE and Amar S: Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis. Proc Natl Acad Sci USA. 108:21247–21252. 2011. View Article : Google Scholar

35 

Srinivasan S, Leeman SE and Amar S: Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice. Clin Vaccine Immunol. 17:699–704. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Abba MC, Drake JA, Hawkins KA, Hu Y, Sun H, Notcovich C, Gaddis S, Sahin A, Baggerly K and Aldaz CM: Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression. Breast Cancer Res. 6:R499–R513. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Wang D, Liu J, Tang K, Xu Z, Xiong X, Rao Q, Wang M and Wang J: Expression of pig7 gene in acute leukemia and its potential to modulate the chemosensitivity of leukemic cells. Leuk Res. 33:28–38. 2009. View Article : Google Scholar

38 

Zhou J, Yang Z, Tsuji T, Gong J, Xie J, Chen C, Li W, Amar S and Luo Z: LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth. Oncogene. 30:1892–1900. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Fernandez-Cobo M, Holland JF and Pogo BG: Transcription profiles of non-immortalized breast cancer cell lines. BMC Cancer. 6:992006. View Article : Google Scholar : PubMed/NCBI

40 

Ludes-Meyers JH, Kil H, Bednarek AK, Drake J, Bedford MT and Aldaz CM: WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene. 23:5049–5055. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Matsumura Y, Matsumura Y, Nishigori C, Horio T and Miyachi Y: PIG7/LITAF gene mutation and overexpression of its gene product in extramammary Paget's disease. Int J Cancer. 111:218–223. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Takeuchi T, Adachi Y and Nagayama T: A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma. Carcinogenesis. 33:548–554. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Eaton HE, Metcalf J, Lacerda AF and Brunetti CR: Accumulation of endogenous LITAF in aggresomes. PLoS One. 7:e300032012. View Article : Google Scholar : PubMed/NCBI

44 

Eaton HE, Desrochers G, Drory SB, Metcalf J, Angers A and Brunetti CR: SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments. PLoS One. 6:e168732011. View Article : Google Scholar : PubMed/NCBI

45 

van Kempen LC, de Visser KE and Coussens LM: Inflammation, proteases and cancer. Eur J Cancer. 42:728–734. 2006. View Article : Google Scholar : PubMed/NCBI

46 

de Visser KE and Coussens LM: The inflammatory tumor microenvironment and its impact on cancer development. Contrib Microbiol. 13:118–137. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Mantovani A, Schioppa T, Porta C, Allavena P and Sica A: Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev. 25:315–322. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Spaeth EL, Dembinski JL, Sasser AK, Watson K, Klopp A, Hall B, Andreeff M and Marini F: Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PloS one. 4:e49922009. View Article : Google Scholar : PubMed/NCBI

49 

Galdiero MR, Garlanda C, Jaillon S, Marone G and Mantovani A: Tumor associated macrophages and neutrophils in tumor progression. J Cell Physiol. 228:1404–1412. 2013. View Article : Google Scholar

50 

Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J, Lang RA and Pollard JW: A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One. 4:e65622009. View Article : Google Scholar : PubMed/NCBI

51 

Itzkowitz SH and Yio X: Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: The role of inflammation. Am J Physiol Gastrointest Liver Physiol. 287:G7–G17. 2004. View Article : Google Scholar : PubMed/NCBI

52 

Gazzaniga S, Bravo AI, Guglielmotti A, van Rooijen N, Maschi F, Vecchi A, Mantovani A, Mordoh J and Wainstok R: Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft. J Invest Dermatol. 127:2031–2041. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Bazzoni F and Beutler B: The tumor necrosis factor ligand and receptor families. N Engl J Med. 334:1717–1725. 1996. View Article : Google Scholar : PubMed/NCBI

54 

Locksley RM, Killeen N and Lenardo MJ: The TNF and TNF receptor superfamilies: Integrating mammalian biology. Cell. 104:487–501. 2001. View Article : Google Scholar : PubMed/NCBI

55 

Zhou J, Yang Z, Tsuji T, Gong J, Xie J, Chen C, Li W, Amar S and Luo Z: LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth. Oncogene. 30:1892–1900. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Pang T, Wang J, Benicky J and Saavedra JM: Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition. Biochim Biophys Acta. 1820:503–510. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zou J, Guo P, Lv N and Huang D: Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review). Mol Med Rep 12: 6399-6404, 2015.
APA
Zou, J., Guo, P., Lv, N., & Huang, D. (2015). Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review). Molecular Medicine Reports, 12, 6399-6404. https://doi.org/10.3892/mmr.2015.4243
MLA
Zou, J., Guo, P., Lv, N., Huang, D."Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)". Molecular Medicine Reports 12.5 (2015): 6399-6404.
Chicago
Zou, J., Guo, P., Lv, N., Huang, D."Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)". Molecular Medicine Reports 12, no. 5 (2015): 6399-6404. https://doi.org/10.3892/mmr.2015.4243
Copy and paste a formatted citation
x
Spandidos Publications style
Zou J, Guo P, Lv N and Huang D: Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review). Mol Med Rep 12: 6399-6404, 2015.
APA
Zou, J., Guo, P., Lv, N., & Huang, D. (2015). Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review). Molecular Medicine Reports, 12, 6399-6404. https://doi.org/10.3892/mmr.2015.4243
MLA
Zou, J., Guo, P., Lv, N., Huang, D."Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)". Molecular Medicine Reports 12.5 (2015): 6399-6404.
Chicago
Zou, J., Guo, P., Lv, N., Huang, D."Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)". Molecular Medicine Reports 12, no. 5 (2015): 6399-6404. https://doi.org/10.3892/mmr.2015.4243
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