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MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity

  • Authors:
    • Chunhui Liu
    • Lei Zhang
    • Yeqing Huang
    • Kai Lu
    • Tao Tao
    • Shuqiu Chen
    • Xiaowen Zhang
    • Han Guan
    • Ming Chen
    • Bin Xu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7389-7395
    |
    Published online on: September 30, 2015
       https://doi.org/10.3892/mmr.2015.4390
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Abstract

Prostate cancer (Pca) has one of the highest mortality rates for malignant cancers worldwide. Previous research has demonstrated that numerous genes are aberrantly expressed during Pca onset and development. p21‑activated protein kinase 6 (PAK6) is known to be overexpressed in primary and metastatic Pca, however the mechanism of this aberrant expression remains unknown. In the present study, immunohistochemistry demonstrated that PAK6 is overexpressed in castration‑resistant Pca (CRPC). Furthermore, PAK6 overexpression was regulated by microRNA (miR)‑328. Luciferase reporter assay and western blot analysis indicated that PAK6 was directly targeted by miR‑328. Forced expression of miR‑328 enhanced docetaxel sensitivity, inhibited cell proliferation and promoted cell apoptosis without affecting the cell cycle. This indicates that miR‑328 performs important functions in CRPC progression via PAK6 regulation. This mechanism may be used to enhance the effect of docetaxel.
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Copy and paste a formatted citation
Spandidos Publications style
Liu C, Zhang L, Huang Y, Lu K, Tao T, Chen S, Zhang X, Guan H, Chen M, Xu B, Xu B, et al: MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity. Mol Med Rep 12: 7389-7395, 2015.
APA
Liu, C., Zhang, L., Huang, Y., Lu, K., Tao, T., Chen, S. ... Xu, B. (2015). MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity. Molecular Medicine Reports, 12, 7389-7395. https://doi.org/10.3892/mmr.2015.4390
MLA
Liu, C., Zhang, L., Huang, Y., Lu, K., Tao, T., Chen, S., Zhang, X., Guan, H., Chen, M., Xu, B."MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity". Molecular Medicine Reports 12.5 (2015): 7389-7395.
Chicago
Liu, C., Zhang, L., Huang, Y., Lu, K., Tao, T., Chen, S., Zhang, X., Guan, H., Chen, M., Xu, B."MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity". Molecular Medicine Reports 12, no. 5 (2015): 7389-7395. https://doi.org/10.3892/mmr.2015.4390
Copy and paste a formatted citation
x
Spandidos Publications style
Liu C, Zhang L, Huang Y, Lu K, Tao T, Chen S, Zhang X, Guan H, Chen M, Xu B, Xu B, et al: MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity. Mol Med Rep 12: 7389-7395, 2015.
APA
Liu, C., Zhang, L., Huang, Y., Lu, K., Tao, T., Chen, S. ... Xu, B. (2015). MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity. Molecular Medicine Reports, 12, 7389-7395. https://doi.org/10.3892/mmr.2015.4390
MLA
Liu, C., Zhang, L., Huang, Y., Lu, K., Tao, T., Chen, S., Zhang, X., Guan, H., Chen, M., Xu, B."MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity". Molecular Medicine Reports 12.5 (2015): 7389-7395.
Chicago
Liu, C., Zhang, L., Huang, Y., Lu, K., Tao, T., Chen, S., Zhang, X., Guan, H., Chen, M., Xu, B."MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity". Molecular Medicine Reports 12, no. 5 (2015): 7389-7395. https://doi.org/10.3892/mmr.2015.4390
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