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Article

MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3

  • Authors:
    • Honglei Yin
    • Lihua Zhao
    • Shaoli Zhang
    • Yan Zhang
    • Suyang Lei
  • View Affiliations / Copyright

    Affiliations: The First Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China, Coronary Care Unit, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China, Coronary Care Unit, The Seventh People's Hospital of Zhengzhou, Zhengzhou, Henan 450006, P.R. China
  • Pages: 8282-8288
    |
    Published online on: October 14, 2015
       https://doi.org/10.3892/mmr.2015.4441
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Abstract

Cardiomyocyte hypertrophy is a threat to human health due to the probability of sudden heart failure‑induced mortality. Previous studies have demonstrated that nuclear factor of activated T cells cytoplasmic 3 (NFATC3) is important in the process of cardiomyocyte hypertrophy. However, the molecular mechanism underlying the alteration in the expression levels of NFATC3 during cardiomyocyte hypertrophy has remained to be fully elucidated. In order to shed light on the molecular mechanism, the present study employed several approaches, including the measurement of the cell surface area, analysis of the protein/DNA ratio, western blot analysis and a Luciferase reporter assay using isolated rat cardiomyocytes as model. The results showed that expression of microRNA‑1 (miR‑1) was reduced in patients diagnosed with cardiac hypertrophy and rat cardiomyocytes treated with pro‑hypertrophic stimuli. The increase in the expression of miR‑1 was able to inhibit the hypertrophic remodeling of cardiomyocytes. The suppression of miR‑1 was sufficient to induce cardiomyocyte hypertrophy, and further experiments confirmed that NFATC3 was a target of miR‑1 in cardiomyocytes. Forced expression of NFATC3 inhibited the protective activity of miR‑1 against hypertrophic stimuli in the cardiomyocytes. These findings provided clarification of the regulatory signaling pathway underlying cardiac hypertrophy, and provided evidence that targeting the miR‑1/NFATC3 pathway may be a promising strategy for the prevention and treatment of heart hypertrophy.
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1 

Huang J, Shelton JM, Richardson JA, Kamm KE and Stull JT: Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy. J Biol Chem. 283:19748–19756. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Valencia-Sanchez MA, Liu J, Hannon GJ and Parker R: Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20:515–524. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Melman YF, Shah R and Das S: MicroRNAs in heart failure: Is the picture becoming less miRky? Circ Heart Fail. 7:203–214. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Ikeda S, He A, Kong SW, Lu J, Bejar R, Bodyak N, Lee KH, Ma Q, Kang PM, Golub TR and Pu WT: MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 29:2193–2204. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Elia L, Contu R, Quintavalle M, Varrone F, Chimenti C, Russo MA, Cimino V, De Marinis L, Frustaci A, Catalucci D and Condorelli G: Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation. 120:2377–2385. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Li Q, Song XW, Zou J, Wang GK, Kremneva E, Li XQ, Zhu N, Sun T, Lappalainen P, Yuan WJ, et al: Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy. J Cell Sci. 123:2444–2452. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Tritsch E, Mallat Y, Lefebvre F, Diguet N, Escoubet B, Blanc J, De Windt LJ, Catalucci D, Vandecasteele G, Li Z and Mericskay M: An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart. Cardiovasc Res. 98:372–380. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Karakikes I, Chaanine AH, Kang S, Mukete BN, Jeong D, Zhang S, Hajjar RJ and Lebeche D: Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling. J Am Heart Assoc. 2:e0000782013. View Article : Google Scholar : PubMed/NCBI

9 

Hou Y, Sun Y, Shan H, Li X, Zhang M, Zhou X, Xing S, Sun H, Chu W, Qiao G and Lu Y: β-adrenoceptor regulates miRNA expression in rat heart. Med Sci Monit. 18:BR309–BR314. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Varrone F, Gargano B, Carullo P, Di Silvestre D, De Palma A, Grasso L, Di Somma C, Mauri P, Benazzi L, Franzone A, et al: The circulating level of FABP3 is an indirect biomarker of microRNA-1. J Am Coll Cardiol. 61:88–95. 2013. View Article : Google Scholar

11 

Wilkins BJ, De Windt LJ, Bueno OF, Braz JC, Glascock BJ, Kimball TF and Molkentin JD: Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calci-neurin-mediated cardiac hypertrophic growth. Mol Cell Biol. 22:7603–7613. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR and Molkentin JD: Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res. 94:110–118. 2004. View Article : Google Scholar

13 

Tan WQ, Wang K, Lv DY and Li PF: Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. J Biol Chem. 283:29730–29739. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Reinhold MI, Abe M, Kapadia RM, Liao Z and Naski MC: FGF18 represses noggin expression and is induced by calcineurin. J Biol Chem. 279:38209–38219. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Liu J, Ma L, Li C, Zhang Z, Yang G and Zhang W: Tumor-targeting TRAIL expression mediated by miRNA response elements suppressed growth of uveal melanoma cells. Mol Oncol. 7:1043–1055. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Ma L, Liu J, Shen J, Liu L, Wu J, Li W, et al: Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells. Cancer Biol Ther. 9:554–561. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Murtaza I, Wang HX, Feng X, Alenina N, Bader M, Prabhakar BS and Li PF: Down-regulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy. J Biol Chem. 283:5996–6004. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Wang K, Long B, Zhou J and Li PF: MiR-9 and NFATc3 regulate myocardin in cardiac hypertrophy. J Biol Chem. 285:11903–11912. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Dai H, Jia G, Liu X, Liu Z and Wang H: Astragalus polysac-charide inhibits isoprenaline-induced cardiac hypertrophy via suppressing Ca2+-mediated calcineurin/NFATc3 and CaMKII signaling cascades. Environ Toxicol Pharmacol. 38:263–271. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Ma L, Liu J, Shen J, Liu L, Wu J, Li W, Luo J, Chen Q and Qian C: Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells. Cancer Biol Ther. 9:554–561. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Bandiera S, Pfeffer S, Baumert TF and Zeisel MB: MiR-122-a key factor and therapeutic target in liver disease. J Hepatol. 62:448–457. 2015. View Article : Google Scholar

22 

Oliveira-Carvalho V, da Silva MM, Guimarães GV, Bacal F and Bocchi EA: MicroRNAs: New players in heart failure. Mol Biol Rep. 40:2663–2670. 2013. View Article : Google Scholar

23 

Li J, Liu Y, Wang C, Deng T, Liang H, Wang Y, Huang D, Fan Q, Wang X, Ning T, et al: Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma. Sci Rep. 5:129212015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yin H, Zhao L, Zhang S, Zhang Y and Lei S: MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3. Mol Med Rep 12: 8282-8288, 2015.
APA
Yin, H., Zhao, L., Zhang, S., Zhang, Y., & Lei, S. (2015). MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3. Molecular Medicine Reports, 12, 8282-8288. https://doi.org/10.3892/mmr.2015.4441
MLA
Yin, H., Zhao, L., Zhang, S., Zhang, Y., Lei, S."MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3". Molecular Medicine Reports 12.6 (2015): 8282-8288.
Chicago
Yin, H., Zhao, L., Zhang, S., Zhang, Y., Lei, S."MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3". Molecular Medicine Reports 12, no. 6 (2015): 8282-8288. https://doi.org/10.3892/mmr.2015.4441
Copy and paste a formatted citation
x
Spandidos Publications style
Yin H, Zhao L, Zhang S, Zhang Y and Lei S: MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3. Mol Med Rep 12: 8282-8288, 2015.
APA
Yin, H., Zhao, L., Zhang, S., Zhang, Y., & Lei, S. (2015). MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3. Molecular Medicine Reports, 12, 8282-8288. https://doi.org/10.3892/mmr.2015.4441
MLA
Yin, H., Zhao, L., Zhang, S., Zhang, Y., Lei, S."MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3". Molecular Medicine Reports 12.6 (2015): 8282-8288.
Chicago
Yin, H., Zhao, L., Zhang, S., Zhang, Y., Lei, S."MicroRNA‑1 suppresses cardiac hypertrophy by targeting nuclear factor of activated T cells cytoplasmic 3". Molecular Medicine Reports 12, no. 6 (2015): 8282-8288. https://doi.org/10.3892/mmr.2015.4441
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