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Article Open Access

Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis

  • Authors:
    • Yonghua Xing
    • Junling Zhang
    • Lu Lu
    • Deguan Li
    • Yueying Wang
    • Song Huang
    • Chengcheng Li
    • Zhubo Zhang
    • Jianguo Li
    • Aimin Meng
  • View Affiliations / Copyright

    Affiliations: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Nankai, Tianjin 300192, P.R. China
    Copyright: © Xing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 107-116
    |
    Published online on: November 13, 2015
       https://doi.org/10.3892/mmr.2015.4566
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Abstract

Irradiation commonly causes pneumocyte senescence, which may lead to severe fatal lung injury characterized by pulmonary dysfunction and respiratory failure. However, the molecular mechanism underlying the induction of pneumocyte senescence by irradiation remains to be elucidated. In the present study, weighted gene co‑expression network analysis (WGCNA) was used to screen for differentially expressed genes, and to identify the hub genes and gene modules, which may be critical for senescence. A total of 2,916 differentially expressed genes were identified between the senescence and non‑senescence groups following thoracic irradiation. In total, 10 gene modules associated with cell senescence were detected, and six hub genes were identified, including B‑cell scaffold protein with ankyrin repeats 1, translocase of outer mitochondrial membrane 70 homolog A, actin filament‑associated protein 1, Cd84, Nuf2 and nuclear factor erythroid 2. These genes were markedly associated with cell proliferation, cell division and cell cycle arrest. The results of the present study demonstrated that WGCNA of microarray data may provide further insight into the molecular mechanism underlying pneumocyte senescence.
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Copy and paste a formatted citation
Spandidos Publications style
Xing Y, Zhang J, Lu L, Li D, Wang Y, Huang S, Li C, Zhang Z, Li J, Meng A, Meng A, et al: Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis. Mol Med Rep 13: 107-116, 2016.
APA
Xing, Y., Zhang, J., Lu, L., Li, D., Wang, Y., Huang, S. ... Meng, A. (2016). Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis. Molecular Medicine Reports, 13, 107-116. https://doi.org/10.3892/mmr.2015.4566
MLA
Xing, Y., Zhang, J., Lu, L., Li, D., Wang, Y., Huang, S., Li, C., Zhang, Z., Li, J., Meng, A."Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis". Molecular Medicine Reports 13.1 (2016): 107-116.
Chicago
Xing, Y., Zhang, J., Lu, L., Li, D., Wang, Y., Huang, S., Li, C., Zhang, Z., Li, J., Meng, A."Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis". Molecular Medicine Reports 13, no. 1 (2016): 107-116. https://doi.org/10.3892/mmr.2015.4566
Copy and paste a formatted citation
x
Spandidos Publications style
Xing Y, Zhang J, Lu L, Li D, Wang Y, Huang S, Li C, Zhang Z, Li J, Meng A, Meng A, et al: Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis. Mol Med Rep 13: 107-116, 2016.
APA
Xing, Y., Zhang, J., Lu, L., Li, D., Wang, Y., Huang, S. ... Meng, A. (2016). Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis. Molecular Medicine Reports, 13, 107-116. https://doi.org/10.3892/mmr.2015.4566
MLA
Xing, Y., Zhang, J., Lu, L., Li, D., Wang, Y., Huang, S., Li, C., Zhang, Z., Li, J., Meng, A."Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis". Molecular Medicine Reports 13.1 (2016): 107-116.
Chicago
Xing, Y., Zhang, J., Lu, L., Li, D., Wang, Y., Huang, S., Li, C., Zhang, Z., Li, J., Meng, A."Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis". Molecular Medicine Reports 13, no. 1 (2016): 107-116. https://doi.org/10.3892/mmr.2015.4566
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