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Article

Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility

  • Authors:
    • Adrianna Mostowska
    • Malgorzata Szczepańska
    • Przemyslaw Wirstlein
    • Jana Skrzypczak
    • Paweł P. Jagodziński
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poznań 60‑781, Poland, Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznań University of Medical Sciences, Poznań 60‑781, Poland
  • Pages: 1040-1046
    |
    Published online on: November 30, 2015
       https://doi.org/10.3892/mmr.2015.4626
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Abstract

Endometriosis is considered to be an epigenetic disease. It has previously been reported that the DNA methyltransferase 3-like (DNMT3L) rs8129776 single nucleotide polymorphism (SNP) contributes to endometrioma. In the present study, high‑resolution melting curve analysis was used to investigate the risks associated with the DNMT3L c.910‑635A/G (rs8129776), c.832C/T (rs7354779), c.812C/T (rs113593938) and c.344+62C/T (rs2276248) SNPs on stage I‑II endometriosis‑associated infertility. Included in the present study were patients presenting with stage I‑II endometriosis‑associated infertility (n=154) and a control cohort of healthy patients with confirmed fertility (n=383). No significant association between the above‑listed DNMT3L SNPs and the development of endometriosis‑associated infertility was identified. The lowest P‑values generated from trend analysis were observed in the DNMT3L c.832C/T (rs7354779) SNP (Ptrend=0.114). Furthermore, haplotype analyses of the DNMT3L SNPs failed to reveal any risk association between the development of endometriosis‑associated infertility and the above‑listed polymorphisms, even when the SNPs were present in combinations. Finally, a meta‑analysis was performed to examine the association between the DNMT3L rs8129776 SNP and the development of endometrioma, from which no association between the two was identified. On the basis of these results, the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.
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Copy and paste a formatted citation
Spandidos Publications style
Mostowska A, Szczepańska M, Wirstlein P, Skrzypczak J and Jagodziński PP: Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility. Mol Med Rep 13: 1040-1046, 2016.
APA
Mostowska, A., Szczepańska, M., Wirstlein, P., Skrzypczak, J., & Jagodziński, P.P. (2016). Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility. Molecular Medicine Reports, 13, 1040-1046. https://doi.org/10.3892/mmr.2015.4626
MLA
Mostowska, A., Szczepańska, M., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility". Molecular Medicine Reports 13.1 (2016): 1040-1046.
Chicago
Mostowska, A., Szczepańska, M., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility". Molecular Medicine Reports 13, no. 1 (2016): 1040-1046. https://doi.org/10.3892/mmr.2015.4626
Copy and paste a formatted citation
x
Spandidos Publications style
Mostowska A, Szczepańska M, Wirstlein P, Skrzypczak J and Jagodziński PP: Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility. Mol Med Rep 13: 1040-1046, 2016.
APA
Mostowska, A., Szczepańska, M., Wirstlein, P., Skrzypczak, J., & Jagodziński, P.P. (2016). Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility. Molecular Medicine Reports, 13, 1040-1046. https://doi.org/10.3892/mmr.2015.4626
MLA
Mostowska, A., Szczepańska, M., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility". Molecular Medicine Reports 13.1 (2016): 1040-1046.
Chicago
Mostowska, A., Szczepańska, M., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility". Molecular Medicine Reports 13, no. 1 (2016): 1040-1046. https://doi.org/10.3892/mmr.2015.4626
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