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Article

Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems

  • Authors:
    • Hee‑Yun Kim
    • Hyun‑Ja Jeong
    • Hyung‑Min Kim
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea, Department of Food Technology, Inflammatory Disease Research Center, Hoseo University, Asan, Chungnam 336‑795, Republic of Korea
  • Pages: 2815-2820
    |
    Published online on: January 27, 2016
       https://doi.org/10.3892/mmr.2016.4809
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Abstract

Depression is a chronic mental disorder. Inflammatory reactions have an important function in the pathophysiology of depression. Ikwitang (IW) has been used to treat fever and inflammatory diseases, however, its effect on depression has not been previously investigated. Therefore, the present study evaluated the possible antidepressant‑like effect of IW using a forced swimming test (FST) in mice. IW was orally administered for 14 days. On the 14 day, IW was administered 1 h prior to the FST. The immobility durations of the IW groups (0.01, 0.1 and 1 g/kg) were significantly decreased, compared with those of the distilled water (D.W.) groups. The reduction of immobility duration by IW was associated with significant increases in the levels of serotonin, noradrenaline and estrogen receptor‑β in the brain. IW significantly increased the levels of brain‑derived neurotrophic factor and phosphorylated extracellular signal‑regulated kinases, compared with the D.W. groups. In addition, the levels of inflammatory cytokines were significantly reduced following IW administration in the hippocampus and serum. In conclusion, the results of the present study suggested that the antidepressant effect of IW may be associated with the modulation of monoaminergic systems and inflammatory reactions.
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1 

Alfonso J, Frasch AC and Flugge G: Chronic stress, depression and antidepressants: Effects on gene transcription in the hippocampus. Rev Neurosci. 16:43–56. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Reeves RR and Ladner ME: Antidepressant-induced suicidality: An update. CNS Neurosci Ther. 16:227–234. 2010.PubMed/NCBI

3 

Shively CA, Mirkes SJ, Lu NZ, Henderson JA and Bethea CL: Soy and social stress affect serotonin neurotransmission in primates. Pharmacogenomics J. 3:114–121. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH and Li XJ: Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem Behav. 82:200–206. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Lee S, Jeong J, Kwak Y and Park SK: Depression research: Where are we now? Mol Brain. 3:82010. View Article : Google Scholar : PubMed/NCBI

6 

Ji XW, Wu CL, Wang XC, Liu J, Bi JZ and Wang DY: Monoamine neurotransmitters and fibroblast growth factor-2 in the brains of rats with post-stroke depression. Exp Ther Med. 8:159–164. 2014.PubMed/NCBI

7 

Watanabe K, Hashimoto E, Ukai W, Ishii T, Yoshinaga T, Ono T, Tateno M, Watanabe I, Shirasaka T, Saito S and Saito T: Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats. Prog Neuropsychopharmacol Biol Psychiatry. 34:1450–1454. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Patterson M and Yasuda R: Signalling pathways underlying structural plasticity of dendritic spines. Braz J Pharmacol. 163:1626–1638. 2011. View Article : Google Scholar

9 

Maes M: Evidence for an immune response in major depression: A review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry. 19:11–38. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Go JH, Jung JH, Chang YJ, Kim HM and Chung YJ: Ikwi-tang for the treatment of allergic rhinitis as a traditional medicine. TANG. 3:37–42. 2013.

11 

Lee YC, Lee JC, Seo YB and Kook YB: Liriopis tuber inhibit OVA-induced airway inflammation and bronchial hyperresponsiveness in murine model of asthma. J Ethnopharmacol. 101:144–152. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Kang M, Shin D, Oh JW, Cho C, Lee HJ, Yoon DW, Lee SM, Yun JH, Choi H, Park S, et al: The anti-depressant effect of Nelumbinis semen on rats under chronic mild stress induced depression-like symptoms. Am J Chin Med. 33:205–213. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

14 

Roh SS, Kim SH, Lee YC and Seo YB: Effects of radix adenophorae and cyclosporine A on an OVA-induced murine model of asthma by suppressing to T cells activity, eosinophilia and bronchial hyperresponsiveness. Mediators Inflamm. 2008:7814252008. View Article : Google Scholar

15 

Masi G and Brovedani P: The hippocampus, neurotrophic factors and depression: Possible implications for the pharmacotherapy of depression. CNS Drugs. 25:913–931. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Walf AA, Koonce CJ and Frye CA: Adult female wildtype, but not oestrogen receptor beta knockout, mice have decreased depression-like behaviour during pro-oestrus and following administration of oestradiol or diarylpropionitrile. J Psychopharmacol. 23:442–450. 2009. View Article : Google Scholar

17 

Schmidt HD and Duman RS: The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol. 18:391–418. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Gerrits M, Westenbroek C, Koch T, Grootkarzijn A and ter Horst GJ: Increased lim-bic phosphorylated extra-cellular-regulated kinase 1 and 2 expression after chronic stress is reduced by cyclic 17beta-estradiol administration. Neuroscience. 142:1293–1302. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Jeong HJ, Kim JH, Kim NR, Yoou MS, Nam SY, Kim KY, Choi Y, Jang JB, Kang IC, Baek NI and Kim HM: Antidepressant effect of Stillen. Arch Pharm Res. 38:1223–1231. 2015. View Article : Google Scholar

20 

Hughes ZA, Liu F, Platt BJ, Dwyer JM, Pulicicchio CM, Zhang G, Schechter LE, Rosenzweig-Lipson S and Day M: WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology. 54:1136–1142. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Petit-Demouliere B, Chenu F and Bourin M: Forced swimming test in mice: A review of antidepressant activity. Psychopharmacology (Berl). 177:245–255. 2005. View Article : Google Scholar

22 

Zheng M, Fan Y, Shi D and Liu C: Antidepressant-like effect of flavonoids extracted from Apocynum venetum leaves on brain monoamine levels and dopaminergic system. J Ethnopharmacol. 147:108–113. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Delgado PL: Depression: The case for a monoamine deficiency. J C Psychiatry. 61(Suppl 6): S7–S11. 2000.

24 

Kumar N, Dhayabaran D, Nampoothiri M, Nandakumar K, Puratchikody A, Lalani N, Dawood K and Ghosh A: Atypical antidepressant activity of 3,4-Bis(3,4-Dimethoxyphenyl) Furan-2,5-Dione Isolated from heart wood of cedrus deodara, in rodents. Korean J Physiol Pharmacol. 18:365–369. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Shughrue PJ, Lane MV and Merchenthaler I: Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J Comp Neurol. 388:507–525. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Rocha BA, Fleischer R, Schaeffer JM, Rohrer SP and Hickey GJ: 17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice. Psychopharmacology (Berl). 179:637–643. 2005. View Article : Google Scholar

27 

Imwalle DB, Gustafsson JA and Rissman EF: Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice. Physiol Behav. 84:157–163. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Binder DK and Scharfman HE: Brain-derived neurotrophic factor. Growth Factors. 22:123–131. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Lee BH and Kim YK: The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Investing. 7:231–235. 2010. View Article : Google Scholar

30 

Heldt SA, Stanek L, Chhatwal JP and Ressler KJ: Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry. 12:656–670. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Johnson GL and Lapadat R: Mitogen-activated protein kinase pathways mediated by ERK, JNK and p38 protein kinases. Science. 298:1911–1912. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Zhang X, Jin C, Li Y, Guan S, Han F and Zhang S: Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by D-galactose. Food Chem Toxicol. 58:50–55. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Capuron L and Miller AH: Immune system to brain signaling: Neuropsychopharmacological implications. Pharmacol Ther. 130:226–238. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Chen W, Li X, Jia LQ, Wang J, Zhang L, Hou D, Wang J and Ren L: Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells. Br J Pharmacol. 169:1140–1152. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim HY, Jeong HJ and Kim HM: Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems. Mol Med Rep 13: 2815-2820, 2016.
APA
Kim, H., Jeong, H., & Kim, H. (2016). Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems. Molecular Medicine Reports, 13, 2815-2820. https://doi.org/10.3892/mmr.2016.4809
MLA
Kim, H., Jeong, H., Kim, H."Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems". Molecular Medicine Reports 13.3 (2016): 2815-2820.
Chicago
Kim, H., Jeong, H., Kim, H."Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems". Molecular Medicine Reports 13, no. 3 (2016): 2815-2820. https://doi.org/10.3892/mmr.2016.4809
Copy and paste a formatted citation
x
Spandidos Publications style
Kim HY, Jeong HJ and Kim HM: Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems. Mol Med Rep 13: 2815-2820, 2016.
APA
Kim, H., Jeong, H., & Kim, H. (2016). Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems. Molecular Medicine Reports, 13, 2815-2820. https://doi.org/10.3892/mmr.2016.4809
MLA
Kim, H., Jeong, H., Kim, H."Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems". Molecular Medicine Reports 13.3 (2016): 2815-2820.
Chicago
Kim, H., Jeong, H., Kim, H."Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems". Molecular Medicine Reports 13, no. 3 (2016): 2815-2820. https://doi.org/10.3892/mmr.2016.4809
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