Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2016 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2016 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats

  • Authors:
    • Zein Shaban Ibrahim
    • Mohamed Elsayed Alkafafy
    • Mohamed Mohamed Ahmed
    • Mohamed Mohamed Soliman
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, College of Medicine, Taif University, Al‑Hawiyah, Taif 21944, Saudi Arabia, Department of Biotechnology, College of Science, Taif University, Al‑Hawiyah, Taif 21944, Saudi Arabia, Department of Medical Laboratories, College of Applied Medical Sciences, Taif University, Turubah, Taif 21974, Saudi Arabia
    Copyright: © Ibrahim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3017-3026
    |
    Published online on: February 22, 2016
       https://doi.org/10.3892/mmr.2016.4922
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The progression of diabetic nephropathy (DN) is accelerated by smoking. The current study investigated the ability of curcumin to protect the kidneys against damage from oxidative stress induced by diabetes mellitus (DM) and nicotine (NC). A total of 24 male Wistar rats were divided into four groups of six rats each. DM was induced by a single intraperitoneal injection of streptozotocin 60 mg/kg body weight. DM rats were treated with or without NC in the absence or presence of curcumin for 8 weeks. As compared with the controls, DM rats exhibited reduced serum levels of high density lipoprotein, superoxide dismutase and glutathione peroxidase, and decreased renal mRNA expression levels of synaptopodin, connexin 43 and erythropoietin (EPO), which were further suppressed by NC and restored to normal levels by curcumin treatment. Additionally, DM rats exhibited increases in their lipid profiles (cholesterol, triacylglycerol and phospholipids), oxidative markers (malondialdehyde, γ‑glutamyltranspeptidase and nitric oxide), kidney function markers (urea and creatinine) and the mRNA expression levels of vimentin, desmin, SREBP‑1, iNOS and TGF‑β1. These effects were further enhanced by NC, but counteracted by curcumin treatment. Kidneys from DM rats displayed glomerular hypertrophy, sclerosis and tubulo‑interstitial changes represented by tubular lipid deposition, interstitial mononuclear cell infiltration and fibroplasia. Pancreatic islets exhibited cellular vacuolation, morphological irregularity and damaged or reduced in size β‑cells. These renal and pancreatic changes became more severe following NC treatment and were ameliorated by curcumin. Therefore, NC‑induced DN progression may predominantly operate by increasing oxidative stress, reducing the levels of antioxidants, suppressing EPO levels, and causing perturbations to gap junction and podocyte structure. Curcumin may ameliorate the damaging effects of DM and NC on the kidney through normalization of the mRNA expression levels of several genes important in the progression of DN.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Gao Q, Shen W, Qin W, Zheng C, Zhang M, Zeng C, Wang S, Wang J, Zhu X and Liu Z: Treatment of db/db diabetic mice with triptolide: A novel therapy for diabetic nephropathy. Nephrol Dial Transplant. 25:3539–3547. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Forbes JM, Coughlan MT and Cooper ME: Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes. 57:1446–1454. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Rossing P, Hougaard P and Parving HH: Risk factors for development of incipient and overt diabetic nephropathy in type 1 diabetic patients: A 10-year prospective observational study. Diabetes Care. 25:859–864. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Sawicki PT, Didjurgeit U, Mühlhauser I, Bender R, Heinemann L and Berger M: Smoking is associated with progression of diabetic nephropathy. Diabetes Care. 17:126–131. 1994. View Article : Google Scholar : PubMed/NCBI

5 

Mühlhauser I, Bender R, Bott U, Jörgens V, Grüsser M, Wagener W, Overmann H and Berger M: Cigarette smoking and progression of retinopathy and nephropathy in type 1 diabetes. Diabet Med. 13:536–543. 1996. View Article : Google Scholar : PubMed/NCBI

6 

De Cosmo S, Lamacchia O, Rauseo A, Viti R, Gesualdo L, Pilotti A, Trischitta V and Cignarelli M: Cigarette smoking is associated with low glomerular filtration rate in male patients with type 2 diabetes. Diabetes Care. 11:2467–2470. 2006. View Article : Google Scholar

7 

Hallan SI and Orth SR: Smoking is a risk factor in the progression to kidney failure. Kidney Int. 80:516–523. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, Dorfman R, Wang Y, Zielenski J, Mastronardi F, et al: Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med. 15:921–929. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Aggarwal BB, Sundaram C, Malani N and Ichikawa H: Curcumin: The Indian solid gold. Adv Exp Med Biol. 595:1–75. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Sharma S, Kulkarni SK and Chopra K: Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 33:940–945. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Meghana K, Sanjeev G and Ramesh B: Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: A prophylactic and protective role. Eur J Pharmacol. 577:183–191. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Chiu J, Khan ZA, Farhangkhoee H and Chakrabarti S: Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition. 25:964–972. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Suvarna SK, Layton C and Bancroft JD: The hematoxylins and eosin. Bancroft's Theory and Practice of Histological Techniques. 7th edition. Churchill Livingstone; London: pp. 172–186. 2013

14 

Liu DG and Wang TM: Role of connective tissue growth factor in experimental radiation nephropathy in rats. Chin Med J (Engl). 121:1925–1931. 2008.

15 

Zheng CX, Chen ZH, Zeng CH, Qin WS, Li LS and Liu ZH: Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro. Kidney Int. 74:596–612. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Gu L, Gao Q, Ni L, Wang M and Shen F: Fasudil inhibits epithelial-myofibroblast transdifferentiation of human renal tubular epithelial HK-2 cells induced by high glucose. Chem Pharm Bull (Tokyo). 61:688–694. 2013. View Article : Google Scholar

17 

Lan X, Rai P, Chandel N, Cheng K, Lederman R, Saleem MA, Mathieson PW, Husain M, Crosson JT, Gupta K, et al: Morphine induces albuminuria by compromising podocyte integrity. PLoS One. 8:e557482013. View Article : Google Scholar : PubMed/NCBI

18 

Benzing T: Signaling at the slit diaphragm. J Am Soc Nephrol. 15:1382–1391. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Satriano J, Mansoury H, Deng A, Sharma K, Vallon V, Blantz RC and Thomson SC: Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes. Am J Physiol Cell Physiol. 299:C374–C380. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Miyauchi M, Toyoda M, Kobayashi K, Abe M, Kobayashi T, Kato M, Yamamoto N, Kimura M, Umezono T and Suzuki D: Hypertrophy and loss of podocytes in diabetic nephropathy. Intern Med. 48:1615–1620. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Zheng M1, Lv LL, Ni J, Ni HF, Li Q, Ma KL and Liu BC: Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy. PLoS One. 6:e204312011. View Article : Google Scholar : PubMed/NCBI

22 

Dousdampanis P, Trigka K and Fourtounas C: Prevalence of anemia in patients with type II diabetes and mild to moderate chronic kidney disease and the impact of anti-RAS medications. Saudi J Kidney Dis Transpl. 25:552–557. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Singh DK, Winocour P and Farrington K: Erythropoietic stress and anemia in diabetes mellitus. Nat Rev Endocrinol. 5:204–210. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Habek D, Habek JC, Ivanisević M and Djelmis J: Fetal tobacco syndrome and perinatal outcome. Fetal Diagn Ther. 6:367–371. 2002. View Article : Google Scholar

25 

Gouva C, Nikolopoulos P, Ioannidis JP and Siamopoulos KC: Treating anemia early in renal failure patients slows the decline of renal function: A randomized controlled trial. Kidney Int. 66:753–760. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Martínez-Morúa A, Soto-Urquieta MG, Franco-Robles E, Zúñiga-Trujillo I, Campos-Cervantes A, Pérez-Vázquez V and Ramírez-Emiliano J: Curcumin decreases oxidative stress in mitochondria isolated from liver and kidneys of high-fat diet-induced obese mice. J Asian Nat Prod Res. 15:905–915. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Ishigaki N, Yamamoto T, Shimizu Y, Kobayashi K, Yatoh S, Sone H, Takahashi A, Suzuki H, Yamagata K, Yamada N and Shimano H: Involvement of glomerular SREBP-1c in diabetic nephropathy. Biochem Biophys Res Commun. 364:502–508. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Uttarwar L, Gao B, Ingram AJ and Krepinsky JC: SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells. Am J Physiol Renal Physiol. 302:F329–F341. 2012. View Article : Google Scholar

29 

Jun H, Song Z, Chen W, Zanhua R, Yonghong S, Shuxia L and Huijun D: In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study. Histochem Cell Biol. 3:327–345. 2009. View Article : Google Scholar

30 

Basile DP: Transforming growth factor-beta as a target for treatment in diabetic nephropathy. Am J Kidney Dis. 38:887–892. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Lv S, Liu G, Sun AG, Wang J, Cheng J, Wang W, Liu X, Nie H and Guan G: Mesenchymal stem cells ameliorate diabetic glomerular fibrosis in vivo and in vitro by inhibiting TGF-β signalling via secretion of bone morphogenetic protein 7. Diab Vasc Dis Res. 11:251–261. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Seoane-Collazo P, Martínez de Morentin PB, Fernø J, Diéguez C, Nogueiras R and López M: Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats. Endocrinology. 155:1679–1689. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Wen X, Zeng Y, Liu L, Zhang H, Xu W, Li N and Jia X: Zhenqing recipe alleviates diabetic nephropathy in experimental type 2 diabetic rats through suppression of SREBP-1c. J Ethnopharmacol. 142:144–150. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Luan J, Li W, Han J, Zhang W, Gong H and Ma R: Renal protection of in vivo administration of tempol in streptozotocin-induced diabetic rats. J Pharmacol Sci. 119:167–176. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Simsek N, Kaya M, Kara A, Can I, Karadeniz A and Kalkan Y: Effects of melatonin on islet neogenesis and beta cell apoptosis in streptozotocin-induced diabetic rats: An immunohistochemical study. Domest Anim Endocrinol. 43:47–57. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Akinola OB, Caxton Martins EA and Dini L: Chronic treatment with ethanolic extract of the leaves of Azadirachta indica ameliorates lesions of pancreatic islets in streptozotocin diabetes. Int J Morphol. 28:291–302. 2010.

37 

Bruin JE, Kellenberger LD, Gerstein HC, Morrison KM and Holloway AC: Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: Identifying critical windows of exposure. Journal of Endocrinology. 194:171–178. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Bruin JE, Petre MA, Lehman MA, Raha S, Gerstein HC, Morrison KM and Holloway AC: Maternal nicotine exposure increases oxidative stress in the offspring. Free Radic Biol Med. 44:1919–1925. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Abdul-Hamid M and Moustafa N: Protective effect of curcumin on histopathology and ultrastructure of pancreas in the alloxan treated rats for induction of diabetes. J Appl Zool. 66:169–179. 2013. View Article : Google Scholar

40 

Ong AC, Jowett TP, Firth JD, Burton S, Kitamura M and Fine LG: Human tubular-derived endothelin in the paracrine regulation of renal interstitial fibroblast function. Exp Nephrol. 2:1341994.PubMed/NCBI

41 

Soetikno V, Suzuki K, Veeraveedu PT, Arumugam S, Lakshmanan AP, Sone H and Watanabe K: Molecular understanding of curcumin in diabetic nephropathy. Drug Discov Today. 18:756–63. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Sassy-Prigent C, Heudes D, Mandet C, Bélair MF, Michel O, Perdereau B, Bariéty J and Bruneval P: Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats. Diabetes. 49:466–475. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Soetikno V, Sari FR, Veeraveedu PT, Thandavarayan RA, Harima M, Sukumaran V, Lakshmanan AP, Suzuki K, Kawachi H and Watanabe K: Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy. Nutr Metab (Lond). 8:352001. View Article : Google Scholar

44 

Asaba K, Tojo A, Onozato ML, Goto A, Quinn MT, Fujita T and Wilcox CS: Effects of NADPH oxidase inhibitor in diabetic nephropathy. Kidney Int. 67:1890–1898. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Goel A, Kunnumakkara AB and Aggarwal BB: Curcumin as 'Curecumin': From kitchen to clinic. Biochem Pharmacol. 75:787–809. 2008. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ibrahim ZS, Alkafafy ME, Ahmed MM and Soliman MM: Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats. Mol Med Rep 13: 3017-3026, 2016.
APA
Ibrahim, Z.S., Alkafafy, M.E., Ahmed, M.M., & Soliman, M.M. (2016). Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats. Molecular Medicine Reports, 13, 3017-3026. https://doi.org/10.3892/mmr.2016.4922
MLA
Ibrahim, Z. S., Alkafafy, M. E., Ahmed, M. M., Soliman, M. M."Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats". Molecular Medicine Reports 13.4 (2016): 3017-3026.
Chicago
Ibrahim, Z. S., Alkafafy, M. E., Ahmed, M. M., Soliman, M. M."Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats". Molecular Medicine Reports 13, no. 4 (2016): 3017-3026. https://doi.org/10.3892/mmr.2016.4922
Copy and paste a formatted citation
x
Spandidos Publications style
Ibrahim ZS, Alkafafy ME, Ahmed MM and Soliman MM: Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats. Mol Med Rep 13: 3017-3026, 2016.
APA
Ibrahim, Z.S., Alkafafy, M.E., Ahmed, M.M., & Soliman, M.M. (2016). Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats. Molecular Medicine Reports, 13, 3017-3026. https://doi.org/10.3892/mmr.2016.4922
MLA
Ibrahim, Z. S., Alkafafy, M. E., Ahmed, M. M., Soliman, M. M."Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats". Molecular Medicine Reports 13.4 (2016): 3017-3026.
Chicago
Ibrahim, Z. S., Alkafafy, M. E., Ahmed, M. M., Soliman, M. M."Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats". Molecular Medicine Reports 13, no. 4 (2016): 3017-3026. https://doi.org/10.3892/mmr.2016.4922
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team