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Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells

  • Authors:
    • Wei Shi
    • Jiagang Deng
    • Rongsheng Tong
    • Yong Yang
    • Xia He
    • Jianzhen Lv
    • Hailian Wang
    • Shaoping Deng
    • Ping Qi
    • Dingding Zhang
    • Yi Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China, Guangxi Province Key Laboratory, Guangxi University of Chinese Medicine, Nanning, Guangxi 530200, P.R. China, Department of Pharmacy, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China, Institute of Organ Transplantation, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3423-3432
    |
    Published online on: February 29, 2016
       https://doi.org/10.3892/mmr.2016.4947
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Abstract

Mangiferin, which is a C‑glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside) purified from plant sources, has recently gained attention due to its various biological activities. The present study aimed to determine the apoptotic effects of mangiferin on A549 human lung adenocarcinoma cells. In vitro studies demonstrated that mangiferin exerted growth‑inhibitory and apoptosis-inducing effects against A549 cells. In addition, mangiferin exhibited anti-tumor properties in A549 xenograft mice in vivo. Mangiferin triggered G2/M phase cell cycle arrest via downregulating the cyclin-dependent kinase 1-cyclin B1 signaling pathway, and induced apoptotic cell death by inhibiting the protein kinase C-nuclear factor-κB pathway. In addition, mangiferin was able to enhance the antiproliferative effects of cisplatin on A549 cells, thus indicating the potential for a combined therapy. Notably, mangiferin exerted anticancer effects in vivo, where it was able to markedly decrease the volume and weight of subcutaneous tumor mass, and expand the lifespan of xenograft mice. The present study clarified the molecular mechanisms underlying mangiferin-induced antitumor activities, and suggested that mangiferin may be considered a potential antineoplastic drug for the future treatment of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Shi W, Deng J, Tong R, Yang Y, He X, Lv J, Wang H, Deng S, Qi P, Zhang D, Zhang D, et al: Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells. Mol Med Rep 13: 3423-3432, 2016.
APA
Shi, W., Deng, J., Tong, R., Yang, Y., He, X., Lv, J. ... Wang, Y. (2016). Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells. Molecular Medicine Reports, 13, 3423-3432. https://doi.org/10.3892/mmr.2016.4947
MLA
Shi, W., Deng, J., Tong, R., Yang, Y., He, X., Lv, J., Wang, H., Deng, S., Qi, P., Zhang, D., Wang, Y."Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells". Molecular Medicine Reports 13.4 (2016): 3423-3432.
Chicago
Shi, W., Deng, J., Tong, R., Yang, Y., He, X., Lv, J., Wang, H., Deng, S., Qi, P., Zhang, D., Wang, Y."Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells". Molecular Medicine Reports 13, no. 4 (2016): 3423-3432. https://doi.org/10.3892/mmr.2016.4947
Copy and paste a formatted citation
x
Spandidos Publications style
Shi W, Deng J, Tong R, Yang Y, He X, Lv J, Wang H, Deng S, Qi P, Zhang D, Zhang D, et al: Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells. Mol Med Rep 13: 3423-3432, 2016.
APA
Shi, W., Deng, J., Tong, R., Yang, Y., He, X., Lv, J. ... Wang, Y. (2016). Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells. Molecular Medicine Reports, 13, 3423-3432. https://doi.org/10.3892/mmr.2016.4947
MLA
Shi, W., Deng, J., Tong, R., Yang, Y., He, X., Lv, J., Wang, H., Deng, S., Qi, P., Zhang, D., Wang, Y."Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells". Molecular Medicine Reports 13.4 (2016): 3423-3432.
Chicago
Shi, W., Deng, J., Tong, R., Yang, Y., He, X., Lv, J., Wang, H., Deng, S., Qi, P., Zhang, D., Wang, Y."Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells". Molecular Medicine Reports 13, no. 4 (2016): 3423-3432. https://doi.org/10.3892/mmr.2016.4947
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