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Article Open Access

Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice

  • Authors:
    • Yuan‑Yuan Deng
    • Muhammad Shamoon
    • Yue He
    • Madhav Bhatia
    • Jia Sun
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China, Department of Pathology, University of Otago, Christchurch 8140, New Zealand
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3881-3885
    |
    Published online on: March 18, 2016
       https://doi.org/10.3892/mmr.2016.5008
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Abstract

The present study aimed to investigate the immunomodulatory effects of mouse cathelicidin-related antimicrobial peptide (CRAMP) on experimental acute pancreatitis (AP). AP is a common clinical condition characterized by acute abdominal inflammation. Innate immune cells and mediators are intrinsically linked to the pathogenesis of AP. Cathelicidins are innate immunity-derived antimicrobial peptides that exert immunomodulatory effects on various host cells. However, how cathelicidins are involved and modulate the severity and inflammatory responses of AP remains unclear. In the present study, the mouse CRAMP gene‑deficient cnlp‑/‑ mice and their wild‑type C57BL/6J littermates were induced with AP by multiple hourly injections of supramaximal doses of caerulein. Serum amylase levels, pancreatic myeloperoxidase activity and histological examination were performed in order to determine the disease severity and the levels of inflammatory cytokines. Disease severity and inflammatory markers were subsequently evaluated in the control mice, cnlp‑/‑ C57BL/6J mice with AP, and wild‑type C57BL/6J mice with AP. The results demonstrated that cnlp‑/‑ mice exhibited a more severe phenotype and inflammatory response following AP induction compared with the wild‑type mice, as evidenced by increased serum amylase levels, pancreatic myeloperoxidase release, and early inflammatory mediator tumor necrosis factor‑α production. Histological examination confirmed that CRAMP deficiency worsened the pancreatic inflammatory condition. These results indicate that CRAMP may be considered a novel modulatory mediator in mouse experimental AP.
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1 

Bell D, Keane MG and Pereira SP: Acute pancreatitis. Medicine. 43:174–181. 2015. View Article : Google Scholar

2 

Petrov M: Nutrition, inflammation, and acute pancreatitis. ISRN Inflamm. 2013:3414102013. View Article : Google Scholar

3 

Kylänpää L, Rakonczay Z Jr and O'Reilly DA: The clinical course of acute pancreatitis and the inflammatory mediators that drive it. Int J Inflam. 2012:3606852012. View Article : Google Scholar

4 

Johnson CD and Abu-Hilal M: Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut. 53:1340–1344. 2004. View Article : Google Scholar : PubMed/NCBI

5 

DiMagno MJ and DiMagno EP: New advances in acute pancreatitis. Curr Opin Gastroenterol. 23:494–501. 2007.PubMed/NCBI

6 

Abdulla A, Awla D, Thorlacius H and Regnér S: Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis. J Leukoc Biol. 90:975–982. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Akinosoglou K and Gogos C: Immune-modulating therapy in acute pancreatitis: Fact or fiction. World J Gastroenterol. 20:15200–15215. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Bhatia M, Neoptolemos JP and Slavin J: Inflammatory mediators as therapeutic targets in acute pancreatitis. Curr Opin Investig Drugs. 2:496–501. 2001.PubMed/NCBI

9 

Cunha DM, Koike MK, Barbeiro DF, Barbeiro HV, Hamasaki MY, Coelho Neto GT, Machado MC and da Silva FP: Increased intestinal production of α-defensins in aged rats with acute pancreatic injury. Exp Gerontol. 60:215–219. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Gallo RL and Hooper LV: Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 12:503–516. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Hiemstra PS: Defensins and cathelicidins in inflammatory lung disease: Beyond antimicrobial activity. Biochem Soc Trans. 34:276–278. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Hilchie AL, Wuerth K and Hancock RE: Immune modulation by multifaceted cationic host defense (antimicrobial) peptides. Nat Chem Biol. 9:761–768. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Sørensen OE, Follin P, Johnsen AH, Calafat J, Tjabringa GS, Hiemstra PS and Borregaard N: Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood. 97:3951–3959. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Zanetti M, Gennaro R and Romeo D: Cathelicidins: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett. 374:1–5. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Zanetti M: The role of cathelicidins in the innate host defenses of mammals. Curr Issues Mol Biol. 7:179–196. 2005.PubMed/NCBI

16 

Shaykhiev R, Beisswenger C, Kändler K, Senske J, Püchner A, Damm T, Behr J and Bals R: Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure. Am J Physiol Lung Cell Mol Physiol. 289:L842–L848. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Nagaoka I, Tamura H and Hirata M: An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7. J Immunol. 176:3044–3052. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Wehkamp J, Harder J, Weichenthal M, Mueller O, Herrlinger KR, Fellermann K, Schroeder JM and Stange EF: Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 9:215–223. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Dawra R, Sah RP, Dudeja V, Rishi L, Talukdar R, Garg P and Saluja AK: Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis. Gastroenterology. 141:2210–2217. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Bhatia M: Apoptosis versus necrosis in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 286:G189–G196. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Sah RP and Saluja A: Molecular mechanisms of pancreatic injury. Curr Opin Gastroenterol. 27:444–451. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Sah RP, Dawra RK and Saluja AK: New insights into the pathogenesis of pancreatitis. Curr Opin Gastroenterol. 29:523–530. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Criddle DN, McLaughlin E, Murphy JA, Petersen OH and Sutton R: The pancreas misled: Signals to pancreatitis. Pancreatology. 7:436–446. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Meguro S, Tomita M, Katsuki T, Kato K, Oh H, Ainai A, Ito R, Kawai T, Itoh H and Hasegawa H: Plasma antimicrobial peptide LL-37 level is inversely associated with HDL cholesterol level in patients with type 2 diabetes mellitus. Int J Endocrinol. 2014:7036962014. View Article : Google Scholar : PubMed/NCBI

25 

Xue J, Sharma V and Habtezion A: Immune cells and immune-based therapy in pancreatitis. Immunol Res. 58:378–386. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Mayerle J, Dummer A, Sendler M, Malla SR, van den Brandt C, Teller S, Aghdassi A, Nitsche C and Lerch MM: Differential roles of inflammatory cells in pancreatitis. J Gastroenterol Hepatol. 27(Suppl 2): 47–51. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP and Slavin J: Inflammatory mediators in acute pancreatitis. JPathol. 190:117–125. 2000. View Article : Google Scholar

28 

Norman JG, Fink GW and Franz MG: Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression. Arch Surg. 130:966–970. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Sun J and Bhatia M: Blockade of neurokinin-1 receptor attenuates CC and CXC chemokine production in experimental acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 292:G143–G153. 2007. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Deng YY, Shamoon M, He Y, Bhatia M and Sun J: Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice. Mol Med Rep 13: 3881-3885, 2016.
APA
Deng, Y., Shamoon, M., He, Y., Bhatia, M., & Sun, J. (2016). Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice. Molecular Medicine Reports, 13, 3881-3885. https://doi.org/10.3892/mmr.2016.5008
MLA
Deng, Y., Shamoon, M., He, Y., Bhatia, M., Sun, J."Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice". Molecular Medicine Reports 13.5 (2016): 3881-3885.
Chicago
Deng, Y., Shamoon, M., He, Y., Bhatia, M., Sun, J."Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice". Molecular Medicine Reports 13, no. 5 (2016): 3881-3885. https://doi.org/10.3892/mmr.2016.5008
Copy and paste a formatted citation
x
Spandidos Publications style
Deng YY, Shamoon M, He Y, Bhatia M and Sun J: Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice. Mol Med Rep 13: 3881-3885, 2016.
APA
Deng, Y., Shamoon, M., He, Y., Bhatia, M., & Sun, J. (2016). Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice. Molecular Medicine Reports, 13, 3881-3885. https://doi.org/10.3892/mmr.2016.5008
MLA
Deng, Y., Shamoon, M., He, Y., Bhatia, M., Sun, J."Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice". Molecular Medicine Reports 13.5 (2016): 3881-3885.
Chicago
Deng, Y., Shamoon, M., He, Y., Bhatia, M., Sun, J."Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice". Molecular Medicine Reports 13, no. 5 (2016): 3881-3885. https://doi.org/10.3892/mmr.2016.5008
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