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Article

Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis

  • Authors:
    • Friederike Liesche
    • Alexandra C. Kölbl
    • Matthias Ilmer
    • Stefan Hutter
    • Udo Jeschke
    • Ulrich Andergassen
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynaecology, Ludwig Maximilians University Munich, D-80337 Munich, Germany, Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University Munich, D-81377 Munich, Germany
  • Pages: 4309-4314
    |
    Published online on: March 24, 2016
       https://doi.org/10.3892/mmr.2016.5044
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Abstract

Glycosylation is one of the most important posttranslational modifications of proteins and lipids that contributes to the structural diversity of cellular molecules. Enzymes of the glycosyltransferase class are responsible for altering glycosylation patterns by adding carbohydrate chains to the respective acceptor molecules. It is well known that glycosylation is commonly altered in cancerous tissue. Therefore, the present study aimed to determine the incidence of N‑acetylgalactosaminyltransferase 6 (GALNT6), a prominent member of the glycosyltransferase class, in breast cancer tissue of different developmental stages by immunohistochemistry. Although no correlation was identified between tumour characteristics and GALNT6 staining intensity, to the best of our knowledge, this is the first study to demonstrate that tissue from carcinoma in situ‑tumours and metastases were more heavily stained than late‑stage breast cancers. This may indicate an important role of glycosylation aberration in escaping the immune system at early phases of tumour development. The present study also hypothesised that nascent or early metastasizing tumours are normally recognized by the immune system of the patient, but glycosylation pattern changes may facilitate tumor escape from immune recognition. In follow‑up studies, our group will aim to confirm and consolidate these results in a larger patient cohort that may give greater insight into breast cancer characterization as well as tumour treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Liesche F, Kölbl AC, Ilmer M, Hutter S, Jeschke U and Andergassen U: Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis. Mol Med Rep 13: 4309-4314, 2016.
APA
Liesche, F., Kölbl, A.C., Ilmer, M., Hutter, S., Jeschke, U., & Andergassen, U. (2016). Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis. Molecular Medicine Reports, 13, 4309-4314. https://doi.org/10.3892/mmr.2016.5044
MLA
Liesche, F., Kölbl, A. C., Ilmer, M., Hutter, S., Jeschke, U., Andergassen, U."Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis". Molecular Medicine Reports 13.5 (2016): 4309-4314.
Chicago
Liesche, F., Kölbl, A. C., Ilmer, M., Hutter, S., Jeschke, U., Andergassen, U."Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis". Molecular Medicine Reports 13, no. 5 (2016): 4309-4314. https://doi.org/10.3892/mmr.2016.5044
Copy and paste a formatted citation
x
Spandidos Publications style
Liesche F, Kölbl AC, Ilmer M, Hutter S, Jeschke U and Andergassen U: Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis. Mol Med Rep 13: 4309-4314, 2016.
APA
Liesche, F., Kölbl, A.C., Ilmer, M., Hutter, S., Jeschke, U., & Andergassen, U. (2016). Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis. Molecular Medicine Reports, 13, 4309-4314. https://doi.org/10.3892/mmr.2016.5044
MLA
Liesche, F., Kölbl, A. C., Ilmer, M., Hutter, S., Jeschke, U., Andergassen, U."Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis". Molecular Medicine Reports 13.5 (2016): 4309-4314.
Chicago
Liesche, F., Kölbl, A. C., Ilmer, M., Hutter, S., Jeschke, U., Andergassen, U."Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis". Molecular Medicine Reports 13, no. 5 (2016): 4309-4314. https://doi.org/10.3892/mmr.2016.5044
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