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Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals

  • Authors:
    • Xingbing Wang
    • Yunxia Zhu
    • Bo Xu
    • Jing Wang
    • Xin Liu
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    Affiliations: Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui 230001, P.R. China, Reproductive Medicine Center, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui 230001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4969-4980
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    Published online on: April 27, 2016
       https://doi.org/10.3892/mmr.2016.5197
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Abstract

Toll‑like receptors (TLRs) are expressed in human bone marrow‑derived mesenchymal stromal cells (BM‑MSCs), and the activation of TLRs is important in proliferation, differentiation, migration and hematopoiesis‑supporting functions of BM‑MSCs. However, the molecular mechanisms underlying these processes remain to be elucidated. MicroRNAs (miRNAs) are involved in various biological functions by mediating mRNA degradation or inhibiting translation of target genes. The present study aimed to identify whether TLRs regulate the expression of miRNAs in BM‑MSCs and elucidate the regulatory roles of miRNAs. Illumina high‑throughput sequencing was used to profile miRNAs expressed in BM‑MSCs stimulated with TLR2 agonist, PAM3CSK4 (PM) or TLR4 agonist, lipopolysaccharides (LPS). A marked expression change upon PM or LPS treatment was observed for 164 known miRNAs and six novel miRNAs that were identified. The expression of six novel miRNAs and 40 randomly selected known miRNAs was further validated by reverse transcription‑quantitative polymerase chain reaction. In addition, bioinformatic methods were used to predict the potential target genes of the abundant known miRNAs. The gene ontology analysis demonstrated that predicted targets were enriched in the regulation of signal transduction, cellular processes and macromolecule metabolic processes. Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that these potential targets were involved in numerous important pathways, predominantly including mitogen‑activated protein kinase, phosphatidylinositol‑4,5‑bisphosphate 3‑kinase‑Akt, neurotrophin and cancer‑associated signaling pathways. The present study aimed to identify the global expression change of miRNAs in BM‑MSCs stimulated with LPS and PM, providing the opportunity to further elucidate the roles of miRNAs in mediating TLR signals to regulate the functions of BM‑MSCs.
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View References

1 

Yates LA, Norbury CJ and Gilbert RJ: The long and short of microRNA. Cell. 153:516–519. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Fabian MR, Sonenberg N and Filipowicz W: Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 79:351–379. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S and Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science. 284:143–147. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, et al: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:41–49. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Charbord P: Bone marrow mesenchymal stem cells: Historical overview and concepts. Hum Gene Ther. 21:1045–1056. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Oreffo RO, Cooper C, Mason C and Clements M: Mesenchymal stem cells: Lineage, plasticity and skeletal therapeutic potential. Stem Cell Rev. 1:169–178. 2005. View Article : Google Scholar

8 

Hwa Cho H, Bae YC and Jung JS: Role of toll-like receptors on human adipose-derived stromal cells. Stem Cells. 24:2744–2752. 2006. View Article : Google Scholar : PubMed/NCBI

9 

van den Berk LC, Jansen BJ, Siebers-Vermeulen KG, Netea MG, Latuhihin T, Bergevoet S, Raymakers RA, Kögler G, Figdor CC, Adema GJ and Torensma R: Toll-like receptor triggering in cord blood mesenchymal stem cells. J Cell Mol Med. 13:3415–3426. 2009. View Article : Google Scholar

10 

Wang X, Cheng Q, Li L, Wang J, Xia L, Xu X and Sun Z: Toll-like receptors 2 and 4 mediate the capacity of mesenchymal stromal cells to support the proliferation and differentiation of CD34+cells. Exp Cell Re. 318:196–206. 2012. View Article : Google Scholar

11 

Benakanakere MR, Li Q, Eskan MA, Singh AV, Zhao J, Galicia JC, Stathopoulou P, Knudsen TB and Kinane DF: Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes. J Biol Chem. 284:23107–23115. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Quinn EM, Wang JH, O'Callaghan G and Redmond HP: MicroRNA-146a is upregulated by and negatively regulates TLR2 signaling. PLoS One. 8:e622322013. View Article : Google Scholar : PubMed/NCBI

13 

O'Hara SP, Splinter PL, Gajdos GB, Trussoni CE, Fernandez-Zapico ME, Chen XM and LaRusso NF: NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection. J Biol Chem. 285:216–225. 2010. View Article : Google Scholar :

14 

Yang K, He YS, Wang XQ, Lu L, Chen QJ, Liu J, Sun Z and Shen WF: MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. FEBS Lett. 585:854–860. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA and Croce CM: Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol. 179:5082–5089. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Curtale G, Mirolo M, Renzi TA, Rossato M, Bazzoni F and Locati M: Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b. Proc Natl Acad Sci USA. 110:11499–11504. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Ceppi M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos MA and Pierre P: MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci USA. 106:2735–2740. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

19 

Hwa Cho H, Bae YC and Jung JS: Role of toll-like receptors on human adipose-derived cells. Stem Cells. 24:2744–2752. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Pevsner-Fischer M, Morad V, Cohen-Sfady M, Rousso-Noori L, Zanin-Zhorov A, Cohen S, Cohen IR and Zipori D: Toll-like receptors and their ligands control mesenchymal stem cell functions. Blood. 109:1422–1432. 2007. View Article : Google Scholar

21 

Liotta F, Angeli R, Cosmi L, Filì L, Manuelli C, Frosali F, Mazzinghi B, Maggi L, Pasini A, Lisi V, et al: Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T cell modulatory activity by 634 impairing Notch signaling. Stem Cells. 26:279–289. 2008. View Article : Google Scholar

22 

Opitz CA, Litzenburger UM, Lutz C, Lanz TV, Tritschler I, Köppel A, Tolosa E, Hoberg M, Anderl J, Aicher WK, et al: Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R. Stem Cells. 27:909–919. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Tomchuck SL, Zwezdaryk KJ, Coffelt SB, Waterman RS, Danka ES and Scandurro AB: Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells. 26:99–107. 2008. View Article : Google Scholar

24 

Romieu-Mourez R, François M, Boivin MN, Bouchentouf M, Spaner DE and Galipeau J: Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol. 182:7963–7973. 2009. View Article : Google Scholar : PubMed/NCBI

25 

White NM, Bao TT, Grigull J, Youssef YM, Girgis A, Diamandis M, Fatoohi E, Metias M, Honey RJ, Stewart R, et al: miRNA profiling for clear cell renal cell carcinoma: Biomarker discovery and identification of potential controls and consequences of miRNA dysregulation. J Urol. 186:1077–1083. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Ma J, Liu J, Wang Z, Gu X, Fan Y, Zhang W, Xu L, Zhang J and Cai D: NF-kappaB-dependent MicroRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction. Mol Cancer. 13:402014. View Article : Google Scholar

27 

Laine SK, Alm JJ, Virtanen SP, Aro HT and Laitala-Leinonen TK: MicroRNAs miR-96, miR-124 and miR-199a regulate gene expression in human bone marrow-derived mesenchymal stem cells. J Cell Biochem. 113:2687–2695. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Chen J, Liu Z and Yang Y: In vitro screening of LPS-induced miRNAs in leukocytes derived from cord blood and their possible roles in regulating TLR signals. Pediatr Res. 75:595–602. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Akiyama H: Control of chondrogenesis by the transcription factor Sox9. Mod Rheumatol. 18:213–219. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Lin EA, Kong L, Bai XH, Luan Y and Liu CJ: miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1. J Biol Chem. 284:11326–11335. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Wu ZY, Lu L, Liang J, Guo XR, Zhang PH and Luo SJ: Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts. Genet Mol Res. 13:2727–2738. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Shi XE, Li YF, Jia L, Ji HL, Song ZY, Cheng J, Wu GF, Song CC, Zhang QL, Zhu JY and Yang GS: MicroRNA-199a-5p affects porcine preadipocyte proliferation and differentiation. Int J Mol Sci. 15:8526–8538. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M and Rajewsky N: Combinatorial microRNA target predictions. Nat Genet. 37:495–500. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Feng Y, Cao JH, Li XY and Zhao SH: Inhibition of miR-214 expression represses proliferation and differentiation of C2C12 myoblasts. Cell Biochem Funct. 29:378–383. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Yang TS, Yang XH, Wang XD, Wang YL, Zhou B and Song ZS: MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN. Cancer Cell Int. 13:682013. View Article : Google Scholar : PubMed/NCBI

36 

Zhang ZC, Li YY, Wang HY, Fu S, Wang XP, Zeng MS, Zeng YX and Shao JY: Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma. PLoS One. 9:e861492014. View Article : Google Scholar : PubMed/NCBI

37 

Derfoul A, Juan AH, Difilippantonio MJ, Palanisamy N, Ried T and Sartorelli V: Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase. Carcinogenesis. 32:1607–1614. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Brzezianska E and Pastuszak-Lewandoska D: A minireview: The role of MAPK/ERK and PI3K/Akt pathways in thyroid follicular cell-derived neoplasm. Front Biosci (Landmark Ed). 16:422–439. 2011. View Article : Google Scholar

39 

Nahid MA, Yao B, Dominguez-Gutierrez PR, Kesavalu L, Satoh M and Chan EK: Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J Immunol. 190:1250–1263. 2013. View Article : Google Scholar :

40 

Ahmed F, Shiraishi T, Vessella RL and Kulkarni P: Tumor necrosis factor receptor associated factor-4: An adapter protein overexpressed in metastatic prostate cancer is regulated by microRNA-29a. Oncol Rep. 30:2963–2968. 2013.PubMed/NCBI

41 

Chen R, Alvero AB, Silasi DA, Kelly MG, Fest S, Visintin I, Leiser A, Schwartz PE, Rutherford T and Mor G: Regulation of IKKB by miR-199a affects NF-kappB activity in ovarian cancer cells. Oncogene. 27:4712–4723. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Zhou R, O'Hara SP and Chen XM: MicroRNA regulation of innate immune responsesin epithelial cells. Cell Mol Immunol. 8:371–379. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Huang Z, Chen X, Yu B and Chen D: Cloning and functional characterization of rat stimulator of interferon genes (STING) regulated by miR-24. Dev Comp Immunol. 37:414–420. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Lai NS, Yu HC, Chen HC, Yu CL, Huang HB and Lu MC: Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis. Clin Exp Immunol. 173:47–57. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Zhao J, Gong AY, Zhou R, Liu J, Eischeid AN and Chen XM: Downregulation of PCAF by miR-181a/b provides feedback regulation to TNF-α-induced transcription of proinflammatory genes in liver epithelial cells. J Immunol. 188:1266–1274. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Sharma A, Kumar M, Aich J, Hariharan M, Brahmachari SK, Agrawal A and Ghosh B: Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a. Proc Natl Acad Sci USA. 106:5761–5766. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Zhang M, Liu Q, Mi S, Liang X, Zhang Z, Su X, Liu J, Chen Y, Wang M, Zhang Y, et al: Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression. J Immunol. 186:4716–4724. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Witwer KW, Sisk JM, Gama L and Clements JE: MicroRNA regulation of IFN-beta protein expression: Rapid and sensitive modulation of the innate immune response. J Immunol. 184:2369–2376. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Lai L, Song Y, Liu Y, Chen Q, Han Q, Chen W, Pan T, Zhang Y, Cao X and Wang Q: MicroRNA-92a negatively regulates Toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase. J Biol Chem. 288:7956–7967. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Qi J, Qiao Y, Wang P, Li S, Zhao W and Gao C: MicroRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-κB1 in murine macrophages. FEBS Lett. 586:1201–1207. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Jennewein C, von Knethen A, Schmid T and Brüne B: MicroRNA-27b contributes to lipopolysaccharide-mediated peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA destabilization. J Biol Chem. 285:11846–11853. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Lu TX, Munitz A and Rothenberg ME: MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol. 182:4994–5002. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Zhu QY, Liu Q, Chen JX, Lan K and Ge BX: MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages. J Immunol. 185:7435–7442. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Liu X, Zhan Z, Xu L, Ma F, Li D, Guo Z, Li N and Cao X: MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα. J Immunol. 185:7244–7251. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Ma F, Chen D, Chi Y, Chen F, Li X and Han Z: The expression and role of miR-301a in human umbilical cord-derived mesenchymal stromal cells. Cytotherapy. 15:1511–1516. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Akira S, Uematsu S and Takeuchi O: Pathogen recognition and innate immunity. Cell. 124:783–801. 2006. View Article : Google Scholar : PubMed/NCBI

57 

Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L and Aderem A: The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA. 97:13766–13771. 2000. View Article : Google Scholar : PubMed/NCBI

58 

Pasare C and Medzhitov R: Toll-like receptors: Linking innate and adaptive immunity. Adv Exp Med Biol. 560:11–18. 2005. View Article : Google Scholar : PubMed/NCBI

59 

Hoebe K, Jiang Z, Georgel P, Tabeta K, Janssen E, Du X and Beutler B: TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy. Curr Pharm Des. 12:4123–4134. 2006. View Article : Google Scholar : PubMed/NCBI

60 

Kawai T and Akira S: TLR signaling. Semin Immunol. 19:24–32. 2007. View Article : Google Scholar : PubMed/NCBI

61 

O'Neill LA and Bowie AG: The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 7:353–364. 2007. View Article : Google Scholar : PubMed/NCBI

62 

DelaRosa O and Lombardo E: Modulation of adult mesenchymal stem cells activity by toll-like receptors: Implications on therapeutic potential. Mediators Inflamm. 2010:8656012010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Zhu Y, Xu B, Wang J and Liu X: Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals. Mol Med Rep 13: 4969-4980, 2016.
APA
Wang, X., Zhu, Y., Xu, B., Wang, J., & Liu, X. (2016). Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals. Molecular Medicine Reports, 13, 4969-4980. https://doi.org/10.3892/mmr.2016.5197
MLA
Wang, X., Zhu, Y., Xu, B., Wang, J., Liu, X."Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals". Molecular Medicine Reports 13.6 (2016): 4969-4980.
Chicago
Wang, X., Zhu, Y., Xu, B., Wang, J., Liu, X."Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals". Molecular Medicine Reports 13, no. 6 (2016): 4969-4980. https://doi.org/10.3892/mmr.2016.5197
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Spandidos Publications style
Wang X, Zhu Y, Xu B, Wang J and Liu X: Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals. Mol Med Rep 13: 4969-4980, 2016.
APA
Wang, X., Zhu, Y., Xu, B., Wang, J., & Liu, X. (2016). Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals. Molecular Medicine Reports, 13, 4969-4980. https://doi.org/10.3892/mmr.2016.5197
MLA
Wang, X., Zhu, Y., Xu, B., Wang, J., Liu, X."Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals". Molecular Medicine Reports 13.6 (2016): 4969-4980.
Chicago
Wang, X., Zhu, Y., Xu, B., Wang, J., Liu, X."Identification of TLR2 and TLR4‑induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals". Molecular Medicine Reports 13, no. 6 (2016): 4969-4980. https://doi.org/10.3892/mmr.2016.5197
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