Open Access

Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence

  • Authors:
    • Hongjun Zhao
    • Chunmei Wu
    • Mengyun Wu
    • Yaou Zhou
    • Honglin Zhu
    • Yisha Li
    • Yunhui You
    • Hui Luo
    • Lijing Wang
    • Xiaoxia Zuo
  • View Affiliations

  • Published online on: May 12, 2016     https://doi.org/10.3892/mmr.2016.5253
  • Pages: 209-217
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multicentric reticulohistiocytosis (MRH) is a rare and debilitating systemic disorder characterized by cutaneous nodules and destructive polyarthritis. Due to its unknown etiology, the treatment of MRH varies with different rates of success, which causes treatment options to be rather independent and empirical. In the present study, a case of a 48‑year‑old woman with a 12‑month history of polyarthralgia and skin nodules was reported. Biopsy samples, which were obtained from her skin eruption exhibited dermal infiltration with histiocytes and multinucleated giant cells. Immunohistochemical staining indicated positivity for CD68. The patient was diagnosed with MRH and treated with a combination therapy of infliximab, prednisolone and methotrexate. Her symptoms improved markedly within 2 weeks. Following the results of this case study, a systematic review of 17 cases of MRH treated with tumor necrosis factor (TNF) antagonists was performed, and the efficacy of anti‑TNF treatment in MRH was analyzed.
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July-2016
Volume 14 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhao H, Wu C, Wu M, Zhou Y, Zhu H, Li Y, You Y, Luo H, Wang L, Zuo X, Zuo X, et al: Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. Mol Med Rep 14: 209-217, 2016
APA
Zhao, H., Wu, C., Wu, M., Zhou, Y., Zhu, H., Li, Y. ... Zuo, X. (2016). Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. Molecular Medicine Reports, 14, 209-217. https://doi.org/10.3892/mmr.2016.5253
MLA
Zhao, H., Wu, C., Wu, M., Zhou, Y., Zhu, H., Li, Y., You, Y., Luo, H., Wang, L., Zuo, X."Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence". Molecular Medicine Reports 14.1 (2016): 209-217.
Chicago
Zhao, H., Wu, C., Wu, M., Zhou, Y., Zhu, H., Li, Y., You, Y., Luo, H., Wang, L., Zuo, X."Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence". Molecular Medicine Reports 14, no. 1 (2016): 209-217. https://doi.org/10.3892/mmr.2016.5253