Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2016 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2016 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence

  • Authors:
    • Hongjun Zhao
    • Chunmei Wu
    • Mengyun Wu
    • Yaou Zhou
    • Honglin Zhu
    • Yisha Li
    • Yunhui You
    • Hui Luo
    • Lijing Wang
    • Xiaoxia Zuo
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Gerontology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 209-217
    |
    Published online on: May 12, 2016
       https://doi.org/10.3892/mmr.2016.5253
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Multicentric reticulohistiocytosis (MRH) is a rare and debilitating systemic disorder characterized by cutaneous nodules and destructive polyarthritis. Due to its unknown etiology, the treatment of MRH varies with different rates of success, which causes treatment options to be rather independent and empirical. In the present study, a case of a 48‑year‑old woman with a 12‑month history of polyarthralgia and skin nodules was reported. Biopsy samples, which were obtained from her skin eruption exhibited dermal infiltration with histiocytes and multinucleated giant cells. Immunohistochemical staining indicated positivity for CD68. The patient was diagnosed with MRH and treated with a combination therapy of infliximab, prednisolone and methotrexate. Her symptoms improved markedly within 2 weeks. Following the results of this case study, a systematic review of 17 cases of MRH treated with tumor necrosis factor (TNF) antagonists was performed, and the efficacy of anti‑TNF treatment in MRH was analyzed.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Islam AD, Naguwa SM, Cheema GS, Hunter JC and Gershwin ME: Multicentric reticulohistiocytosis: A rare yet challenging disease. Clin Rev Allergy Immunol. 45:281–289. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Baek IW, Yoo SH, Yang H, Park J, Kim KJ and Cho CS: A case of multicentric reticulohistiocytosis. Mod Rheumatol. 11:1–4. 2014. View Article : Google Scholar

3 

Gorman JD, Danning C, Schumacher HR, Klippel JH and Davis JC Jr: Multicentric reticulohistiocytosis: Case report with immunohistochemical analysis and literature review. Arthritis Rheum. 43:930–938. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Bennàssar A, Mas A, Guilabert A, Julià M, Mascaró-Galy JM and Herrero C: Multicentric reticulohistiocytosis with elevated cytokine serum levels. J Dermatol. 38:905–910. 2011.PubMed/NCBI

5 

de Vries HS, van Oijen MG, Driessen RJ, de Jong EM, Creemers MC, Kievit W and de Jong DJ: Appropriate infliximab infusion dosage and monitoring: Results of a panel meeting of rheumatologists, dermatologists and gastroenterologists. Br J Clin Pharmacol. 71:7–19. 2011. View Article : Google Scholar :

6 

Shannon SE, Schumacher HR, Self S and Brown AN: Multicentric reticulohistiocytosis responding to tumor necrosis factor-alpha inhibition in a renal transplant patient. J Rheumatol. 32:565–567. 2005.PubMed/NCBI

7 

Iwata H, Okumura Y, Seishima M and Aoyama Y: Overexpression of monocyte chemoattractant protein. 1 in the overlying epidermis of multicentric reticulohistiocytosis lesions: A case report. Int J Dermatol. 51:492–494. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Kovach BT, Calamia KT, Walsh JS and Ginsburg WW: Treatment of multicentric reticulohistiocytosis with etanercept. Arch Dermatol. 140:919–921. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Broadwell AW, Calamia KT, Kransdorf MJ and Ginsburg WW: Healing of erosive disease in multicentric reticulohistiocytosis. J Rheumatol. 37:1366–1367. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Matejicka C, Morgan GJ and Schlegelmilch JG: Multicentric reticulohistiocytosis treated successfully with an anti-tumor necrosis factor agent: Comment on the article by Gorman et al. Arthritis Rheum. 48:864–866. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Lovelace K, Loyd A, Adelson D, Crowson N, Taylor JR and Cornelison R: Etanercept and the treatment of multi-centric reticulohistiocytosis. Arch Dermatol. 141:1167–1168. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Chauhan A, Mikulik Z and Hackshaw KV: Multicentric reticu-lohistiocytosis with positive anticyclic citrullinated antibodies. J Natl Med Assoc. 99:678–680. 2007.PubMed/NCBI

13 

Saba R, Kwatra SG, Upadhyay B, Mirrakhimov AE and Khan FN: Multicentric reticulohistiocytosis presenting with papulonodular skin lesions and arthritis mutilans. Case Rep Rheumatol. 2013:2015632013.PubMed/NCBI

14 

Sellam J, Deslandre CJ, Dubreuil F, Arfi S and Kahan A: Refractory multicentric reticulohistiocytosis treated by infliximab: Two cases. Clin Exp Rheumatol. 23:97–99. 2005.PubMed/NCBI

15 

Lee MW, Lee EY, Jeong YI, Choi JH, Moon KC and Koh JK: Successful treatment of multicentric reticulohistiocytosis with a combination of infliximab, prednisolone and methotrexate. Acta Derm Venereol. 84:478–479. 2004.

16 

Chiba E, Oda A, Tsutsumi T, Yabe H, Kamiya Y, Sakurai T, Moriguchi M, Momomura S and Terai C: Case report; a case with multicentric reticulohistiocytosis successfully treated with infliximab. Nihon Naika Gakkai Zasshi. 100:483–486. 2011. View Article : Google Scholar : PubMed/NCBI

17 

De Knop KJ, Aerts NE, Ebo DG, Van Offel JF, Stevens WJ and De Clerck LS: Multicentric reticulohistiocytosis associated arthritis responding to anti-TNF and methotrexate. Acta Clin Belg. 66:66–69. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Macía-Villa CC and Zea-Mendoza A: Multicentric reticulohistiocytosis: Case report with response to infliximab and review of treatment options. Clin Rheumatol. Apr 15–2014.Epub ahead of print.

19 

Kalajian AH and Callen JP: Multicentric reticulohistiocytosis successfully treated with infliximab: An illustrative case and evaluation of cytokine expression supporting anti-tumor necrosis factor therapy. Arch Dermatol. 144:1360–1366. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Matiz C, Ferguson PJ, Zaenglein A, Groh B and Bingham CA: Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant? Pediatr Rheumatol Online J. 7:152009. View Article : Google Scholar : PubMed/NCBI

21 

Yeter KC and Arkfeld DG: Treatment of multicentric reticulohistiocytosis with adalimumab, minocycline, methotrexate. Int J Rheum Dis. 16:105–106. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Tashiro A, Takeuchi S, Nakahara T, Oba J, Tsujita J, Fukushi J, Kiryu H, Oda Y, Xie L, Yan X, et al: Aberrant expression of CD10 in ground-glass-like multinucleated giant cells of multicentric reticulohistiocytosis. J Dermatol. 37:995–997. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Ma X and Xu S: TNF inhibitor therapy for rheumatoid arthritis. Biomed Rep. 1:177–184. 2013.

24 

Lubrano E, Spadaro A, Amato G, Benucci M, Cavazzana I, Chimenti MS, Ciancio G, D'Alessandro G, Angelis RD, Lupoli S, et al: Tumour necrosis factor alpha inhibitor therapy and rehabilitation for the treatment of ankylosing spondylitis: A systematic review. Semin Arthritis Rheum. 44:542–550. 2015. View Article : Google Scholar

25 

Behrens F, Cañete JD, Olivieri I, van Kuijk AW, McHugh N and Combe B: Tumour necrosis factor inhibitor monotherapy vs combination with MTX in the treatment of PsA: A systematic review of the literature. Rheumatology (Oxford). 54:915–926. 2015. View Article : Google Scholar

26 

Schreiber S: An update on biosimilar drugs for inflammatory bowel disease. Expert Rev Gastroenterol Hepatol. 9(Suppl 1): 1–3. PubMed/NCBI

27 

Jung SM, Kim HS, Kim HR, Kim NY, Lee JH, Kim J, Kwok SK, Park KS, Park SH, Kim HY and Ju JH: Immunogenicity of anti-tumour necrosis factor therapy in Korean patients with rheumatoid arthritis and ankylosing spondylitis. Int Immunopharmacol. 21:20–25. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Scheinfeld N: A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab. J Dermatolog Treat. 15:280–294. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Trotta F and Colina M: Multicentric reticulohistiocytosis and fibroblastic rheumatism. Best Pract Res Clin Rheumatol. 26:543–557. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Ehlers S: Tumor necrosis factor and its blockade in granulo-matous infections: Differential modes of action of infliximab and etanercept? Clin Infect Dis. 41(Suppl 3): S199–S203. 2005. View Article : Google Scholar

31 

Lonsdale-Eccles AA, Haworth AE, McCrae FC and Young-Min SA: Successful treatment of multicentric reticulohistiocytosis with leflunomide. Br J Dermatol. 161:470–472. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Thalayasingam N and Isaacs JD: Anti-TNF therapy. Best Pract Res Clin Rheumatol. 25:549–567. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Pascual-Salcedo D, Plasencia C, Ramiro S, Nuño L, Bonilla G, Nagore D, Ruiz Del Agua A, Martínez A, Aarden L, Martín-Mola E and Balsa A: Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis. Rheumatology (Oxford). 50:1445–1452. 2011. View Article : Google Scholar

34 

Finckh A, Dudler J, Wermelinger F, Ciurea A, Kyburz D, Gabay C and Bas S; physicians of SCQM: Influence of anti-infliximab antibodies and residual infliximab concentrations on the occurrence of acquired drug resistance to infliximab in rheumatoid arthritis patients. Joint Bone Spine. 77:313–318. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Rosenblum H and Amital H: Anti-TNF therapy: Safety aspects of taking the risk. Autoimmun Rev. 10:563–568. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao H, Wu C, Wu M, Zhou Y, Zhu H, Li Y, You Y, Luo H, Wang L, Zuo X, Zuo X, et al: Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. Mol Med Rep 14: 209-217, 2016.
APA
Zhao, H., Wu, C., Wu, M., Zhou, Y., Zhu, H., Li, Y. ... Zuo, X. (2016). Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. Molecular Medicine Reports, 14, 209-217. https://doi.org/10.3892/mmr.2016.5253
MLA
Zhao, H., Wu, C., Wu, M., Zhou, Y., Zhu, H., Li, Y., You, Y., Luo, H., Wang, L., Zuo, X."Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence". Molecular Medicine Reports 14.1 (2016): 209-217.
Chicago
Zhao, H., Wu, C., Wu, M., Zhou, Y., Zhu, H., Li, Y., You, Y., Luo, H., Wang, L., Zuo, X."Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence". Molecular Medicine Reports 14, no. 1 (2016): 209-217. https://doi.org/10.3892/mmr.2016.5253
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao H, Wu C, Wu M, Zhou Y, Zhu H, Li Y, You Y, Luo H, Wang L, Zuo X, Zuo X, et al: Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. Mol Med Rep 14: 209-217, 2016.
APA
Zhao, H., Wu, C., Wu, M., Zhou, Y., Zhu, H., Li, Y. ... Zuo, X. (2016). Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. Molecular Medicine Reports, 14, 209-217. https://doi.org/10.3892/mmr.2016.5253
MLA
Zhao, H., Wu, C., Wu, M., Zhou, Y., Zhu, H., Li, Y., You, Y., Luo, H., Wang, L., Zuo, X."Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence". Molecular Medicine Reports 14.1 (2016): 209-217.
Chicago
Zhao, H., Wu, C., Wu, M., Zhou, Y., Zhu, H., Li, Y., You, Y., Luo, H., Wang, L., Zuo, X."Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence". Molecular Medicine Reports 14, no. 1 (2016): 209-217. https://doi.org/10.3892/mmr.2016.5253
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team