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Article Open Access

Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis

  • Authors:
    • Peiheng He
    • Ziji Zhang
    • Weiming Liao
    • Dongliang Xu
    • Ming Fu
    • Yan Kang
  • View Affiliations / Copyright

    Affiliations: Department of Joint Surgery, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1587-1593
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    Published online on: June 23, 2016
       https://doi.org/10.3892/mmr.2016.5423
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Abstract

The current study aimed to identify gene signatures during rheumatoid arthritis (RA) and osteoarthritis (OA), and used these to elucidate the underlying modular mechanisms. Using the Gene Expression Omnibus database, the present study obtained the GSE7669 mRNA expression microarray data from RA and OA synovial fibroblasts (n=6 each). The differentially expressed genes (DEGs) in RA synovial samples compared with OA samples were identified using the Linear Models for Microarray Analysis package. The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using the Database for Annotation Visualization and Integrated Discovery. A protein‑protein interaction network was constructed and the modules were further analyzed using the Molecular Complex Detection plugin of Cytoscape. A total of 181 DEGs were identified by comparing RA and OA synovial samples (96 up‑ and 85 downregulated genes). The significant DEGs in module 1, including collagen, type I, α 1 (COL1A1), COL3A1, COL4A1 and COL11A1, were predominantly enriched in the extracellular matrix (ECM)‑receptor interaction and focal adhesion pathways. Additionally, significant DEGs in module 2, including radical S‑adenosyl methionine domain containing 2 (RSAD2), 2'‑5'‑oligoadenylate synthetase 2 (OAS2), myxovirus (influenza virus) resistance 1 (MX1) and ISG15 ubiquitin‑like modifier (ISG15), were predominantly associated with immune function pathways. In conclusion, the present study indicated that RSAD2, OAS2, MX1 and ISG15 may be notable gene signatures in RA development via regulation of the immune response. COL3A1, COL4A1, COL1A1 and COL11A1 may be important gene signatures in OA development via involvement in the pathways of ECM-receptor interactions and focal adhesions.
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1 

McInnes IB and Schett G: The pathogenesis of rheumatoid arthritis. N Engl J Med. 365:2205–2219. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Wong JB, Ramey DR and Singh G: Long-term morbidity, mortality, and economics of rheumatoid arthritis. Arthritis Rheum. 44:2746–2749. 2001. View Article : Google Scholar

3 

Loeser RF, Goldring SR, Scanzello CR and Goldring MB: Osteoarthritis: A disease of the joint as an organ. Arthritis Rheum. 64:1697–1707. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Wang HJ, Yu CL, Kishi H, Motoki K, Mao ZB and Muraguchi A: Suppression of experimental osteoarthritis by adenovirus-mediated double gene transfer. Chin Med J (Engl). 119:1365–1373. 2006.

5 

Huber R, Hummert C, Gausmann U, Pohlers D, Koczan D, Guthke R and Kinne RW: Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane. Arthritis Res Ther. 10:R982008. View Article : Google Scholar : PubMed/NCBI

6 

van den Berg WB: Osteoarthritis year 2010 in review: Pathomechanisms. Osteoarthritis Cartilage. 19:338–341. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Knevel R, Gröndal G, Huizinga TW, Visser AW, Jónsson H, Víkingsson A, Geirsson AJ, Steinsson K and van der Helm-van Mil AH: Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: A population-based study. Ann Rheum Dis. 71:707–709. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Bian Q, Wang YJ, Liu SF and Li YP: Osteoarthritis: Genetic factors, animal models, mechanisms, and therapies. Front Biosci (Elite Ed). 4:74–100. 2012. View Article : Google Scholar

9 

Bax M, van Heemst J, Huizinga TW and Toes RE: Genetics of rheumatoid arthritis: What have we learned? Immunogenetics. 63:459–466. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Sun Y, Caplazi P, Zhang J, Mazloom A, Kummerfeld S, Quinones G, Senger K, Lesch J, Peng I, Sebrell A, et al: PILRα negatively regulates mouse inflammatory arthritis. J Immunol. 193:860–870. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Castaño Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, et al: Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. Proc Natl Acad Sci USA. 109:8218–8223. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM, Mangino M, Tamm A, Kerna I, Hart DJ, et al: Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum. 62:2347–2352. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Yoshida S, Arakawa F, Higuchi F, Ishibashi Y, Goto M, Sugita Y, Nomura Y, Niino D, Shimizu K, Aoki R, et al: Gene expression analysis of rheumatoid arthritis synovial lining regions by cDNA microarray combined with laser microdis-section: Up-regulation of inflammation-associated STAT1, IRF1, CXCL9, CXCL10, and CCL5. Scand J Rheumatol. 41:170–179. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Chanalaris A: Identification of a gene signature for osteoarthritis by comparing microarray data from rodent and human cartilage studies. Osteoarthritis Cartilage. 22:S348–S349. 2014. View Article : Google Scholar

15 

Lu QY, Han QH, Li X, Li ZC, Pan YT, Liu L and Fu QG: Analysis of differentially expressed genes between rheumatoid arthritis and osteoarthritis based on the gene co-expression network. Mol Med Rep. 10:119–124. 2014.PubMed/NCBI

16 

Singh S, Snijesh V and Vennila JJ: Rheumatoid arthritis candidate genes identification by investigating core and periphery interaction structures. Computational Intelligence in Medical Informatics. Muppalaneni NB and Gunjan VK: 1st edition. Springer-Verlag; Singapore: pp. 87–96. 2015

17 

Pohlers D, Beyer A, Koczan D, Wilhelm T, Thiesen HJ and Kinne RW: Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther. 9:R592007. View Article : Google Scholar : PubMed/NCBI

18 

Gautier L, Cope L, Bolstad BM and Irizarry RA: Affy - analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Smyth GK: Limma: Linear models for microarray data. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Gentleman R, Carey V, Huber W, Irizarry R and Dudoit S: Springer-Verlag; New York, NY: pp. 397–420. 2005, View Article : Google Scholar

21 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene Ontology: Tool for the unification of biology. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Research. 28:27–30. 2000. View Article : Google Scholar

23 

Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC and Lempicki RA: The DAVID Gene Functional Classification Tool: A novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 8:R1832007. View Article : Google Scholar : PubMed/NCBI

24 

von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P and Snel B: STRING: A database of predicted functional associations between proteins. Nucleic Acids Res. 31:258–261. 2003. View Article : Google Scholar : PubMed/NCBI

25 

He X and Zhang J: Why do hubs tend to be essential in protein networks? PLoS Genet. 2:e882006. View Article : Google Scholar : PubMed/NCBI

26 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

28 

Olex AL, Turkett WH, Fetrow JS and Loeser RF: Integration of gene expression data with network-based analysis to identify signaling and metabolic pathways regulated during the development of osteoarthritis. Gene. 542:38–45. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Koelling S, Kruegel J, Irmer M, Path JR, Sadowski B, Miro X and Miosge N: Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell. 4:324–335. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Clements DN, Fitzpatrick N, Carter SD and Day PJ: Cartilage gene expression correlates with radiographic severity of canine elbow osteoarthritis. Vet J. 179:211–218. 2009. View Article : Google Scholar

31 

Cui S, Zhang X, Hai S, Lu H, Chen Y, Li C, Tong P, Lu F and Yuan Z: Molecular mechanisms of osteoarthritis using gene microarrays. Acta Histochemica. 117:62–68. 2015. View Article : Google Scholar

32 

Rao ZT, Wang SQ and Wang JQ: Exploring the osteoarthritis-related genes by gene expression analysis. Eur Rev Med Pharmacol Sci. 18:3056–3062. 2014.PubMed/NCBI

33 

Remst DF, Blom AB, Vitters EL, Bank RA, van den Berg WB, Blaney Davidson EN and Kraan PM: Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor β-responsive genes in osteoarthritis-related fibrosis. Arthritis Rheum. 66:647–656. 2014. View Article : Google Scholar

34 

Raine EV, Dodd AW, Reynard LN and Loughlin J: Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues. BMC Musculoskelet Disord. 14:852013. View Article : Google Scholar : PubMed/NCBI

35 

Van Vijven JP, Luijsterburg PA, Verhagen AP, Van Osch GJ, Kloppenburg M and Bierma-Zeinstra SM: Symptomatic and chon-droprotective treatment with collagen derivatives in osteoarthritis: A systematic review. Osteoarthritis Cartilage. 20:809–821. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, et al: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 447:661–678. 2007. View Article : Google Scholar

37 

Hammaker D, Boyle DL and Firestein GS: Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis. Rheumatology (Oxford). 51:610–618. 2012. View Article : Google Scholar

38 

Lübbers J, Brink M, van de Stadt LA, Vosslamber S, Wesseling JG, van Schaardenburg D, Rantapää-Dahlqvist S and Verweij CL: The type I IFN signature as a biomarker of preclinical rheumatoid arthritis. Arthritis Res Ther. 72:776–780. 2013.

39 

Raterman HG, Vosslamber S, de Ridder S, Nurmohamed MT, Lems WF, Boers M, van de Wiel M, Dijkmans BA, Verweij CL and Voskuyl AE: The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients. Arthritis Res Ther. 4:R952012. View Article : Google Scholar

40 

Galligan CL, Baig E, Bykerk V, Keystone EC and Fish EN: Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: Correlates with disease activity. Genes Immun. 8:480–491. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Boyle DL, Soma K, Hodge J, Kavanaugh A, Mandel D, Mease P, Shurmur R, Singhal AK, Wei N, Rosengren S, et al: The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis. Ann Rheum Dis. 74:1311–1316. 2015. View Article : Google Scholar :

42 

Le Bon A and Tough DF: Links between innate and adaptive immunity via type I interferon. Curr Opin Immunol. 14:432–436. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Smith SL, Plant D, Eyre S and Barton A: The potential use of expression profiling: Implications for predicting treatment response in rheumatoid arthritis. Ann Rheum Dis. 72:1118–1124. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He P, Zhang Z, Liao W, Xu D, Fu M and Kang Y: Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis. Mol Med Rep 14: 1587-1593, 2016.
APA
He, P., Zhang, Z., Liao, W., Xu, D., Fu, M., & Kang, Y. (2016). Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis. Molecular Medicine Reports, 14, 1587-1593. https://doi.org/10.3892/mmr.2016.5423
MLA
He, P., Zhang, Z., Liao, W., Xu, D., Fu, M., Kang, Y."Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis". Molecular Medicine Reports 14.2 (2016): 1587-1593.
Chicago
He, P., Zhang, Z., Liao, W., Xu, D., Fu, M., Kang, Y."Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis". Molecular Medicine Reports 14, no. 2 (2016): 1587-1593. https://doi.org/10.3892/mmr.2016.5423
Copy and paste a formatted citation
x
Spandidos Publications style
He P, Zhang Z, Liao W, Xu D, Fu M and Kang Y: Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis. Mol Med Rep 14: 1587-1593, 2016.
APA
He, P., Zhang, Z., Liao, W., Xu, D., Fu, M., & Kang, Y. (2016). Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis. Molecular Medicine Reports, 14, 1587-1593. https://doi.org/10.3892/mmr.2016.5423
MLA
He, P., Zhang, Z., Liao, W., Xu, D., Fu, M., Kang, Y."Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis". Molecular Medicine Reports 14.2 (2016): 1587-1593.
Chicago
He, P., Zhang, Z., Liao, W., Xu, D., Fu, M., Kang, Y."Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis". Molecular Medicine Reports 14, no. 2 (2016): 1587-1593. https://doi.org/10.3892/mmr.2016.5423
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