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Article Open Access

Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells

  • Authors:
    • Wen‑Xiang Li
    • Meng‑Xuan Yang
    • Xin‑Qiang Hong
    • Tian‑Geng Dong
    • Tuo Yi
    • Sheng‑Li Lin
    • Xin‑Yu Qin
    • Wei‑Xin Niu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Zhongshan Hospital of Fudan University, Shanghai 200032, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3059-3065
    |
    Published online on: August 19, 2016
       https://doi.org/10.3892/mmr.2016.5652
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Abstract

The enhanced motility of cancer cells via the remodeling of the actin cytoskeleton is crucial in the process of cancer cell invasion and metastasis. It was previously demonstrated that gelsolin (GSN) may be involved as a tumor or a metastasis suppressor, depending on the cell lines and model systems used. In the present study, the effect of GSN on the growth and invasion of human colon carcinoma (CC) cells was investigated using reverse transcription quantitative polymerase chain reaction and western blotting. It was observed that upregulation of the expression of GSN in human CC cells significantly reduced the invasiveness of these cells. The expression levels of GSN were observed to be reduced in CC cells, and the reduced expression level of GSN was often associated with a poorer metastasis‑free survival rate in patients with CC (P=0.04). In addition, the overexpression of GSN inhibited the invasion of CC cells in vitro. Furthermore, GSN was observed to inhibit signal transducer and activator of transcription (STAT) 3 signaling in CC cells. Together, these results suggested that GSN is critical in regulating cytoskeletal events and inhibits the invasive and/or metastatic potential of CC cells. The results obtained in the present study may improve understanding of the functional and mechanistic links between GSN as a possible tumor suppressor and the STAT3 signaling pathway, with respect to the aggressive nature of CC. In addition, the present study demonstrated the importance of GSN in regulating the invasion and metastasis of CC cells at the molecular level, suggesting that GSN may be a potential predictor of prognosis and treatment success in CC.
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Copy and paste a formatted citation
Spandidos Publications style
Li WX, Yang MX, Hong XQ, Dong TG, Yi T, Lin SL, Qin XY and Niu WX: Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells. Mol Med Rep 14: 3059-3065, 2016.
APA
Li, W., Yang, M., Hong, X., Dong, T., Yi, T., Lin, S. ... Niu, W. (2016). Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells. Molecular Medicine Reports, 14, 3059-3065. https://doi.org/10.3892/mmr.2016.5652
MLA
Li, W., Yang, M., Hong, X., Dong, T., Yi, T., Lin, S., Qin, X., Niu, W."Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells". Molecular Medicine Reports 14.4 (2016): 3059-3065.
Chicago
Li, W., Yang, M., Hong, X., Dong, T., Yi, T., Lin, S., Qin, X., Niu, W."Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells". Molecular Medicine Reports 14, no. 4 (2016): 3059-3065. https://doi.org/10.3892/mmr.2016.5652
Copy and paste a formatted citation
x
Spandidos Publications style
Li WX, Yang MX, Hong XQ, Dong TG, Yi T, Lin SL, Qin XY and Niu WX: Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells. Mol Med Rep 14: 3059-3065, 2016.
APA
Li, W., Yang, M., Hong, X., Dong, T., Yi, T., Lin, S. ... Niu, W. (2016). Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells. Molecular Medicine Reports, 14, 3059-3065. https://doi.org/10.3892/mmr.2016.5652
MLA
Li, W., Yang, M., Hong, X., Dong, T., Yi, T., Lin, S., Qin, X., Niu, W."Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells". Molecular Medicine Reports 14.4 (2016): 3059-3065.
Chicago
Li, W., Yang, M., Hong, X., Dong, T., Yi, T., Lin, S., Qin, X., Niu, W."Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells". Molecular Medicine Reports 14, no. 4 (2016): 3059-3065. https://doi.org/10.3892/mmr.2016.5652
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