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Article Open Access

Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model

Corrigendum in: /10.3892/mmr.2025.13641
  • Authors:
    • Jue Wang
    • Dong Han
    • Miao Sun
    • Juan Feng
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Shengjing Hospital, Affiliated Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4162-4172
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    Published online on: September 19, 2016
       https://doi.org/10.3892/mmr.2016.5747
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Abstract

Cerebral ischemic postconditioning (IPOC) has been demonstrated to be neuroprotective against cerebral ischemia reperfusion injury. The present study aimed to determine whether IPOC could inhibit autophagy and high mobility group box 1 (HMGB1) release in a PC12 cell oxygen glucose deprivation/reperfusion (OGD/R) model. An 8 h OGD and 24 h reperfusion cellular model was developed to mimic cerebral ischemia reperfusion injury, with 3 cycles of 10 min OGD/5 min reperfusion treatment to imitate IPOC. Cell viability was determined to demonstrate the efficiency of OGD/R, IPOC and autophagy activator, rapamycin (RAP), treatment. Transmission electron microscopy was performed to observe the formation of autophagosomes, and immunofluorescence, western blot and co‑immunoprecipitation were used to examine the expression of autophagy‑associated proteins and HMGB1. Enzyme‑linked immunosorbent assay analysis was conducted to examine the level of HMGB1 in cell supernatants. Additionally, PC12 cells were treated with RAP to examine the effect of autophagy on HMGB1 release, and the effect of recombinant human HMGB1 and Beclin1 small interfering RNA on autophagy was investigated. The present study confirmed that IPOC inhibited autophagy and HMGB1 secretion, autophagy inhibition induced a decrease in HMGB1 secretion, and HMGB1 secretion attenuation caused autophagy inhibition in return, as demonstrated by immunofluorescence and western blot analyses. Autophagy inhibition and HMGB1 secretion attenuation were, therefore, demonstrated to form a feedback loop under IPOC. These mechanisms illustrated the protective effects of IPOC and may accelerate the clinical use of IPOC.
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1 

Writing Group Members, ; Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, et al: Executive summary: Heart disease and stroke statistics-2016 update: A report from the American heart association. Circulation. 133:447–454. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Zhao H: Ischemic postconditioning as a novel avenue to protect against brain injury after stroke. J Cereb Blood Flow Metab. 29:873–885. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Duanmu WS, Cao L, Chen JY, Ge HF, Hu R and Feng H: Ischemic postconditioning protects against ischemic brain injury by up-regulation of acid-sensing ion channel 2a. Neural Regen Res. 11:641–645. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Han D, Zhang S, Fan B, Wen LL, Sun M, Zhang H and Feng J: Ischemic postconditioning protects the neurovascular unit after focal cerebral ischemia/reperfusion injury. J Mol Neurosci. 53:50–58. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Yuan Y, Guo Q, Ye Z, Pingping X, Wang N and Song Z: Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. Brain Res. 1367:85–93. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Zhu C, Xu F, Wang X, Shibata M, Uchiyama Y, Blomgren K and Hagberg H: Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J Neurochem. 96:1016–1027. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Li J, Han B, Ma X and Qi S: The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats. Brain Res. 1356:11–23. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Bowen ID, Mullarkey K and Margen SM: Programmed cell death during meta-morphosis in the blow-fly Calliphora vormitoria. Microsc Res Tech. 34:202–217. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Wen YD, Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, Han F, Fukunaga K and Qin ZH: Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy. 4:762–769. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, et al: Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol. 172:454–469. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Gao L, Jiang T, Guo J, Liu Y, Cui G, Gu L, Su L and Zhang Y: Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats. PLoS One. 7:e460922012. View Article : Google Scholar : PubMed/NCBI

12 

Chakrabarti L, Eng J, Ivanov N, Garden GA and La Spada AR: Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death. Mol Brain. 2:242009. View Article : Google Scholar : PubMed/NCBI

13 

Erlich S, Shohami E and Pinkas-Kramarski R: Neurodegeneration induces upregulation of Beclin 1. Autophagy. 2:49–51. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y and Yoshimori T: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720–5728. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Goodwin GH, Sanders C and Johns EW: A new group of chromatin associated proteins with a high content of acidic and basic amino acids. Eur J Biochem. 38:14–19. 1973. View Article : Google Scholar : PubMed/NCBI

16 

Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, et al: HMGB-1 as a late mediator of endotoxin lethality in mice. Science. 285:248–251. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Yang QW, Wang JZ, Li JC, Zhou Y, Zhong Q, Lu FL and Xiang J: High-mobility group protein box-1 and its relevance to cerebral ischemia. J Cereb Blood Flow Metab. 30:243–254. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Huang JM, Hu J, Chen N and Hu ML: Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke. J Crit Care. 28:792–797. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Rickenbacher A, Jang JH, Limani P, Ungethüm U, Lehmann K, Oberkofler CE, Weber A, Graf R, Humar B and Clavien PA: Fasting protects liver from ischemic injury through sirt1-mediated downregulation of circulating HMGB1 in mice. J Hepatol. 61:301–308. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Nakamura T, Yamada S and Yoshioka T: Brain hypothermic therapy dramatically decreases elevated blood concentrations of high mobility group box 1 in neonates with hypoxic-ischemic encephalopathy. Dis Markers. 35:327–330. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Wang Q, Wang F, Li X, Yang Q, Li X, Xu N, Huang Y, Zhang Q, Gou X, Chen S and Xiong L: Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats. J Neuroinflammation. 9:242012. View Article : Google Scholar : PubMed/NCBI

22 

Kang R, Zeh HJ, Lotze MT and Tang D: The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18:571–580. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Thorburn J, Frankel AE and Thorburn A: Regulation of HMGB1 release by autophagy. Autophagy. 5:247–249. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ III and Lotze MT: High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab. 13:701–711. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P, Hoppe G, Bianchi ME, Tracey KJ, Zeh HJ III and Lotze MT: Endogenous HMGB1 regulates autophagy. J Cell Biol. 190:881–892. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Tang D, Kang R, Cheh CW, Livesey KM, Liang X, Schapiro NE, Benschop R, Sparvero LJ, Amoscato AA, Tracey KJ, et al: HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. 29:5299–5310. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Juhaszova M, Zorov DB, Yaniv Y, Nuss HB, Wang S and Sollott SJ: Role of glycogen synthase kinase-3beta in cardioprotection. Circ Res. 104:1240–1252. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Cuervo AM: Autophagy: In sickness and in health. Trends Cell Biol. 14:70–77. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Sheng R, Zhang LS, Han R, Liu XQ, Gao B and Qin ZH: Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Autophagy. 6:482–494. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Su J, Zhang T, Wang K, Zhu T and Li X: Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats. Neurochem Res. 39:2068–2077. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Wang JY, Xia Q, Chu KT, Pan J, Sun LN, Zeng B, Zhu YJ, Wang Q, Wang K and Luo BY: Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: A widely used inhibitor of autophagy. J Neuropathol Exp Neurol. 70:314–322. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Pattingre S, Tassa A, Qu XP, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD and Levine B: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 122:927–939. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Funderburk SF, Wang QJ and Yue Z: The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond. Trends Cell Biol. 20:355–362. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Cui D, Wang L, Qi A, Zhou Q, Zhang X and Jiang W: Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. PLoS One. 7:e353242012. View Article : Google Scholar : PubMed/NCBI

35 

Wang J, Han D, Sun M and Feng J: A combination of remote ischemic perconditioning and cerebral ischemic postconditioning inhibits autophagy to attenuate plasma HMGB1 and induce neuroprotection against stroke in rat. J Mol Neurosci. 58:424–431. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Zhang CC, Krieg S and Shapiro DJ: HMG-1 stimulates estrogen response element binding by estrogen receptor from stably transfected HeLa cells. Mol Endocrinol. 13:632–643. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, et al: HMG1 as a late mediator of endotoxin lethality in mice. Science. 285:248–251. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Hayakawa K, Mishima K, Nozako M, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Iwasaki K and Fujiwara M: Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box 1-inhibiting mechanism. Stroke. 39:951–958. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Qiu J, Nishimura M, Wang Y, Sims JR, Qiu S, Savitz SI, Salomone S and Moskowitz MA: Early release of HMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab. 28:927–938. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Nakahara T, Tsuruta R, Kaneko T, Yamashita S, Fujita M, Kasaoka S, Hashiguchi T, Suzuki M, Maruyama I and Maekawa T: High-mobility group box 1 protein in CSF of patients with subarachnoid hemorrhage. Neurocrit Care. 11:362–368. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Han D, Sun M and Feng J: Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model Corrigendum in /10.3892/mmr.2025.13641. Mol Med Rep 14: 4162-4172, 2016.
APA
Wang, J., Han, D., Sun, M., & Feng, J. (2016). Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model Corrigendum in /10.3892/mmr.2025.13641. Molecular Medicine Reports, 14, 4162-4172. https://doi.org/10.3892/mmr.2016.5747
MLA
Wang, J., Han, D., Sun, M., Feng, J."Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model Corrigendum in /10.3892/mmr.2025.13641". Molecular Medicine Reports 14.5 (2016): 4162-4172.
Chicago
Wang, J., Han, D., Sun, M., Feng, J."Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model Corrigendum in /10.3892/mmr.2025.13641". Molecular Medicine Reports 14, no. 5 (2016): 4162-4172. https://doi.org/10.3892/mmr.2016.5747
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Han D, Sun M and Feng J: Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model Corrigendum in /10.3892/mmr.2025.13641. Mol Med Rep 14: 4162-4172, 2016.
APA
Wang, J., Han, D., Sun, M., & Feng, J. (2016). Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model Corrigendum in /10.3892/mmr.2025.13641. Molecular Medicine Reports, 14, 4162-4172. https://doi.org/10.3892/mmr.2016.5747
MLA
Wang, J., Han, D., Sun, M., Feng, J."Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model Corrigendum in /10.3892/mmr.2025.13641". Molecular Medicine Reports 14.5 (2016): 4162-4172.
Chicago
Wang, J., Han, D., Sun, M., Feng, J."Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model Corrigendum in /10.3892/mmr.2025.13641". Molecular Medicine Reports 14, no. 5 (2016): 4162-4172. https://doi.org/10.3892/mmr.2016.5747
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