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Article

Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis

  • Authors:
    • Hong‑Yan Shen
    • Lan‑Zhen Li
    • Ke‑Cheng Xue
    • Dan‑Dan Hu
    • Yu‑Jun Gao
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Breast Surgery, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China, Department of Surgery, People's Hospital of Linzi District Affiliated to Binzhou Medical College, Zibo, Shandong 255400, P.R. China
  • Pages: 2620-2624
    |
    Published online on: March 16, 2017
       https://doi.org/10.3892/mmr.2017.6338
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Abstract

The present study demonstrated the effect of fucoidan, isolated from Fucus vesiculosus, on cell growth and apoptosis in anaplastic thyroid cancer cells. The cell viability was analyzed using a Cell Counting Kit‑8 cell proliferation kit. Diamidino-2-phenylindole and terminal deoxynucleotidyl transferase-mediated dUTP nick‑end labeling assays were used to examine the apoptotic effect of fucoidan, which revealed the presence of apoptotic bodies and DNA fragmentation. Fucoidan inhibited the growth of FTC133 and TPC1 ATC cells in a dose‑dependent manner. It also induced the apoptosis of FTC133 cells by promoting the expression levels of cleaved poly ADP‑ribose polymerase and caspase‑3. Significant decreases in the levels expression of hypoxia-inducible factor 1α and vascular endothelial growth factor were observed in the FTC133 cells following treatment of the cells with fucoidan. In addition, inhibition in tube formation and the migration of FTC133 cells were observed in the cells treated with fucoidan, compared with the cells in the control group. Therefore, fucoidan inhibited cell growth, induced apoptosis and suppressed angiogenesis in the thyroid cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Shen HY, Li LZ, Xue KC, Hu DD and Gao YJ: Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis. Mol Med Rep 15: 2620-2624, 2017.
APA
Shen, H., Li, L., Xue, K., Hu, D., & Gao, Y. (2017). Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis. Molecular Medicine Reports, 15, 2620-2624. https://doi.org/10.3892/mmr.2017.6338
MLA
Shen, H., Li, L., Xue, K., Hu, D., Gao, Y."Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis". Molecular Medicine Reports 15.5 (2017): 2620-2624.
Chicago
Shen, H., Li, L., Xue, K., Hu, D., Gao, Y."Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis". Molecular Medicine Reports 15, no. 5 (2017): 2620-2624. https://doi.org/10.3892/mmr.2017.6338
Copy and paste a formatted citation
x
Spandidos Publications style
Shen HY, Li LZ, Xue KC, Hu DD and Gao YJ: Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis. Mol Med Rep 15: 2620-2624, 2017.
APA
Shen, H., Li, L., Xue, K., Hu, D., & Gao, Y. (2017). Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis. Molecular Medicine Reports, 15, 2620-2624. https://doi.org/10.3892/mmr.2017.6338
MLA
Shen, H., Li, L., Xue, K., Hu, D., Gao, Y."Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis". Molecular Medicine Reports 15.5 (2017): 2620-2624.
Chicago
Shen, H., Li, L., Xue, K., Hu, D., Gao, Y."Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis". Molecular Medicine Reports 15, no. 5 (2017): 2620-2624. https://doi.org/10.3892/mmr.2017.6338
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