1
|
Bressler NM: Age-related macular
degeneration is the leading cause of blindness. JAMA.
291:1900–1901. 2004. View Article : Google Scholar : PubMed/NCBI
|
2
|
Ramkumar HL, Zhang J and Chan CC: Retinal
ultrastructure of murine models of dry age-related macular
degeneration (AMD). Prog Retin Eye Res. 29:169–190. 2010.
View Article : Google Scholar : PubMed/NCBI
|
3
|
Ambati J and Fowler BJ: Mechanisms of
age-related macular degeneration. Neuron. 75:26–39. 2012.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Jager RD, Mieler WF and Miller JW:
Age-related macular degeneration. N Engl J Med. 358:2606–2617.
2008. View Article : Google Scholar : PubMed/NCBI
|
5
|
Chen C, Cano M, Wang JJ, Li J, Huang C, Yu
Q, Herbert TP, Handa JT and Zhang SX: Role of unfolded protein
response dysregulation in oxidative injury of retinal pigment
epithelial cells. Antioxid Redox Signal. 20:2091–2106. 2014.
View Article : Google Scholar : PubMed/NCBI
|
6
|
Salminen A, Kauppinen A, Hyttinen JM,
Toropainen E and Kaarniranta K: Endoplasmic reticulum stress in
age-related macular degeneration: Trigger for neovascularization.
Mol Med. 16:535–542. 2010. View Article : Google Scholar : PubMed/NCBI
|
7
|
Libby RT and Gould DB: Endoplasmic
reticulum stress as a primary pathogenic mechanism leading to
age-related macular degeneration. Adv Exp Med Biol. 664:403–409.
2010. View Article : Google Scholar : PubMed/NCBI
|
8
|
Bi M, Naczki C, Koritzinsky M, Fels D,
Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, et al: ER
stress-regulated translation increases tolerance to extreme hypoxia
and promotes tumor growth. EMBO J. 24:3470–3481. 2005. View Article : Google Scholar : PubMed/NCBI
|
9
|
Häcker G: ER-stress and apoptosis:
Molecular mechanisms and potential relevance in infection. Microbes
Infect. 16:805–810. 2014. View Article : Google Scholar : PubMed/NCBI
|
10
|
Mei Y, Thompson MD, Cohen RA and Tong X:
Endoplasmic reticulum stress and related pathological processes. J
Pharmacol Biomed Anal. 1:10001072013.PubMed/NCBI
|
11
|
Dandekar A, Mendez R and Zhang K: Cross
talk between ER stress, oxidative stress, and inflammation in
health and disease. Methods Mol Biol. 1292:205–214. 2015.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Rizzuto R, Pinton P, Carrington W, Fay FS,
Fogarty KE, Lifshitz LM, Tuft RA and Pozzan T: Close contacts with
the endoplasmic reticulum as determinants of mitochondrial Ca2+
responses. Science. 280:1763–1766. 1998. View Article : Google Scholar : PubMed/NCBI
|
13
|
Hiramatsu N, Chiang WC, Kurt TD, Sigurdson
CJ and Lin JH: Multiple mechanisms of unfolded protein
response-induced cell death. Am J Pathol. 185:1800–1808. 2015.
View Article : Google Scholar : PubMed/NCBI
|
14
|
Wu H, Ng BS and Thibault G: Endoplasmic
reticulum stress response in yeast and humans. Biosci Rep. 34:pii:
e00118. 2014. View Article : Google Scholar
|
15
|
Liu Z, Lv Y, Zhao N, Guan G and Wang J:
Protein kinase R-like ER kinase and its role in endoplasmic
reticulum stress-decided cell fate. Cell Death Dis. 6:e18222015.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Jing G, Wang JJ and Zhang SX: ER stress
and apoptosis: A new mechanism for retinal cell death. Exp Diabetes
Res. 2012:5895892012. View Article : Google Scholar : PubMed/NCBI
|
17
|
Pollreisz A, Afonyushkin T, Oskolkova OV,
Gruber F, Bochkov VN and Schmidt-Erfurth U: Retinal pigment
epithelium cells produce VEGF in response to oxidized phospholipids
through mechanisms involving ATF4 and protein kinase CK2. Exp Eye
Res. 116:177–184. 2013. View Article : Google Scholar : PubMed/NCBI
|
18
|
Wang Y, Alam GN, Ning Y, Visioli F, Dong
Z, Nör JE and Polverini PJ: The unfolded protein response induces
the angiogenic switch in human tumor cells through the PERK/ATF4
pathway. Cancer Res. 72:5396–5406. 2012. View Article : Google Scholar : PubMed/NCBI
|
19
|
Doh SH, Kim JH, Lee KM, Park HY and Park
CK: Retinal ganglion cell death induced by endoplasmic reticulum
stress in a chronic glaucoma model. Brain Res. 1308:158–166. 2010.
View Article : Google Scholar : PubMed/NCBI
|
20
|
Miranda S, González-Rodriguez Á,
Garcia-Ramirez M, Revuelta-Cervantes J, Hernández C, Simó R and
Valverde ÁM: Beneficial effects of fenofibrate in retinal pigment
epithelium by the modulation of stress and survival signaling under
diabetic conditions. J Cell Physiol. 227:2352–2362. 2012.
View Article : Google Scholar : PubMed/NCBI
|
21
|
Atkins C, Liu Q, Minthorn E, Zhang SY,
Figueroa DJ, Moss K, Stanley TB, Sanders B, Goetz A, Gaul N, et al:
Characterization of a novel PERK kinase inhibitor with antitumor
and antiangiogenic activity. Cancer Res. 73:1993–2002. 2013.
View Article : Google Scholar : PubMed/NCBI
|
22
|
Axten JM, Medina JR, Feng Y, Shu A,
Romeril SP, Grant SW, Li WH, Heerding DA, Minthorn E, Mencken T, et
al: Discovery of
7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-p
yrrolo [2,3-d]pyrimidin-4-amine (GSK2606414), a potent and
selective first-in-class inhibitor of protein kinase R (PKR)-like
endoplasmic reticulum kinase (PERK). J Med Chem. 55:7193–7207.
2012. View Article : Google Scholar : PubMed/NCBI
|
23
|
Moreno JA, Halliday M, Molloy C, Radford
H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA
and Mallucci GR: Oral treatment targeting the unfolded protein
response prevents neurodegeneration and clinical disease in
prion-infected mice. Sci Transl Med. 5:206ra1382013. View Article : Google Scholar : PubMed/NCBI
|
24
|
Krishnamoorthy J, Rajesh K, Mirzajani F,
Kesoglidou P, Papadakis AI and Koromilas AE: Evidence for eIF2α
phosphorylation-independent effects of GSK2656157, a novel
catalytic inhibitor of PERK with clinical implications. Cell Cycle.
13:801–806. 2014. View
Article : Google Scholar : PubMed/NCBI
|
25
|
Axten JM, Romeril SP, Shu A, Ralph J,
Medina JR, Feng Y, Li WH, Grant SW, Heerding DA, Minthorn E, et al:
Discovery of GSK2656157: An optimized PERK inhibitor selected for
preclinical development. Acs Med Chem Lett. 4:964–968. 2013.
View Article : Google Scholar : PubMed/NCBI
|
26
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
27
|
Pereira ER, Liao N, Neale GA and
Hendershot LM: Transcriptional and post-transcriptional regulation
of proangiogenic factors by the unfolded protein response. PLoS
One. 5:pii: e12521. 2010. View Article : Google Scholar
|
28
|
Wang H, Blais J, Ron D and Cardozo T:
Structural determinants of PERK inhibitor potency and selectivity.
Chem Biol Drug Des. 76:480–495. 2010. View Article : Google Scholar : PubMed/NCBI
|
29
|
Pereira ER, Frudd K, Awad W and Hendershot
LM: Endoplasmic reticulum (ER) stress and hypoxia response pathways
interact to potentiate hypoxia-inducible factor 1 (HIF-1)
transcriptional activity on targets like vascular endothelial
growth factor (VEGF). J Biol Chem. 289:3352–3364. 2014. View Article : Google Scholar : PubMed/NCBI
|
30
|
Liegl R, Koenig S, Siedlecki J, Haritoglou
C, Kampik A and Kernt M: Temsirolimus inhibits proliferation and
migration in retinal pigment epithelial and endothelial cells via
mTOR inhibition and decreases VEGF and PDGF expression. PloS One.
9:e882032014. View Article : Google Scholar : PubMed/NCBI
|
31
|
Campochiaro PA: Ocular neovascularization.
J Mol Med (Berl). 91:311–321. 2013. View Article : Google Scholar : PubMed/NCBI
|
32
|
Donnelly N, Gorman AM, Gupta S and Samali
A: The eIF2α kinases: Their structures and functions. Cell Mol Life
Sci. 70:3493–3511. 2013. View Article : Google Scholar : PubMed/NCBI
|
33
|
Szegezdi E, Logue SE, Gorman AM and Samali
A: Mediators of endoplasmic reticulum stress-induced apoptosis.
Embo Rep. 7:880–885. 2006. View Article : Google Scholar : PubMed/NCBI
|
34
|
Zinszner H, Kuroda M, Wang X, Batchvarova
N, Lightfoot RT, Remotti H, Stevens JL and Ron D: CHOP is
implicated in programmed cell death in response to impaired
function of the endoplasmic reticulum. Genes Dev. 12:982–995. 1998.
View Article : Google Scholar : PubMed/NCBI
|
35
|
Zhang SX, Sanders E, Fliesler SJ and Wang
JJ: Endoplasmic reticulum stress and the unfolded protein responses
in retinal degeneration. Exp Eye Res. 125:30–40. 2014. View Article : Google Scholar : PubMed/NCBI
|
36
|
Wang F, Rendahl KG, Manning WC, Quiroz D,
Coyne M and Miller SS: AAV-mediated expression of vascular
endothelial growth factor induces choroidal neovascularization in
rat. Invest Ophthalmol Vis Sci. 44:781–790. 2003. View Article : Google Scholar : PubMed/NCBI
|
37
|
Cao J, Zhao L, Li Y, Liu Y, Xiao W, Song
Y, Luo L, Huang D, Yancopoulos GD, Wiegand SJ and Wen R: A
subretinal matrigel rat choroidal neovascularization (CNV) model
and inhibition of CNV and associated inflammation and fibrosis by
VEGF trap. Invest Ophthalmol Vis Sci. 51:6009–6017. 2010.
View Article : Google Scholar : PubMed/NCBI
|
38
|
Saishin Y, Saishin Y, Takahashi K, Silva
Lima e R, Hylton D, Rudge JS, Wiegand SJ and Campochiaro PA:
VEGF-TRAP(R1R2) suppresses choroidal neovascularization and
VEGF-induced breakdown of the blood-retinal barrier. J Cell
Physiol. 195:241–248. 2003. View Article : Google Scholar : PubMed/NCBI
|