Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2017 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2017 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis

  • Authors:
    • Kaoru Ikubo
    • Kyosuke Yamanishi
    • Nobutaka Doe
    • Takuya Hashimoto
    • Miho Sumida
    • Yuko Watanabe
    • Yosif El‑Darawish
    • Wen Li
    • Haruki Okamura
    • Hiromichi Yamanishi
    • Hisato Matsunaga
  • View Affiliations / Copyright

    Affiliations: Department of Neuropsychiatry, Hyōgo College of Medicine, Nishinomiya, Hyōgo 663‑8501, Japan, Laboratory of Neurogenesis and CNS Repair, Hyōgo College of Medicine, Nishinomiya, Hyōgo 663‑8501, Japan, Department of Psychology, Hyōgo University of Health Sciences, Kobe, Hyōgo 650‑8530, Japan, Hirakata General Hospital for Developmental Disorders, Hirakata, Osaka 573‑0122, Japan, Laboratory of Tumor Immunology and Cell Therapy, Hyōgo College of Medicine, Nishinomiya, Hyōgo 663‑8501, Japan
  • Pages: 301-309
    |
    Published online on: May 11, 2017
       https://doi.org/10.3892/mmr.2017.6577
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Major depressive disorder (MDD) is a prevalent disorder that causes considerable disability in social functioning and is a risk factor for physical diseases. Recent clinical reports have demonstrated a marked association between MDD and physiological dyshomeostasis induced by metabolic disorders, including diabetes, hormone abnormalities and autoimmune diseases. The authors of the present study have previously analyzed comparative gene expression profiles in the prefrontal cortex (PFC) of a chronic mild stress (CMS) animal model of MDD. Hepatocyte nuclear factor 4α (Hnf4α) was identified as a central regulator that exerted significant influence on genes associated with physiological homeostasis. The aim of the present study was to investigate: i) the molecular mechanism of the depressive state in the PFC, and ii) the involvement of genes extracted from the comparative gene expression profiles, particularly those applicable to MDD in clinical practice. Core analysis of the previous PFC microarray results was performed using Ingenuity Pathway Analysis (IPA). Subsequently, IPA was used to search for molecules that are regulated by Hnf4α, and exist in the PFC and serum. From the core analysis, 5 genes that are associated with cell death and are expressed in the cortex were selected. Four of the extracted genes, insulin‑like growth factor 1, transthyretin, serpin family A member 3 and plasminogen, were markedly affected by Hnf4α. S100 calcium‑binding protein A9 (S100a9) and α2-HS-glycoprotein (Ahsg) were also chosen as they exist in serum and are also affected by Hnf4α. A significant group difference in the expression of these two genes was detected in the PFC, thalamus and hippocampus. The protein levels of AHSG and S100A9 in the PFC and hippocampus of the CMS group increased significantly when compared with the control group. These findings support the close association of Hnf4α (through genes such as S100a9 and Ahsg) with the development of various diseases induced by deregulation of physiological homeostasis during the progression of MDD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Health Statistics Office, Vital, Health and Social Statistics Division, . Patient Survey. Japan: Ministry of Health, Labour and Welfare; 2011, http://www.mhlw.go.jp/english/database/db-hss/ps.html

2 

Ministry of Health, Labour and Welfare. Health, Labour and Welfare Report, . Ministry of Health, Labour and Welfare. Japan: 2010, http://www.mhlw.go.jp/english/wp/wp-hw5/index.html

3 

Slattery DA, Hudson AL and Nutt DJ: Invited review: The evolution of antidepressant mechanisms. Fundam Clin Pharmacol. 18:1–21. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Young EA and Korszun A: The hypothalamic-pituitary-gonadal axis in mood disorders. Endocrinol Metab Clin North Am. 31:63–78. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Paizanis E, Hamon M and Lanfumey L: Hippocampal neurogenesis, depressive disorders, and antidepressant therapy. Neural Plast. 2007:737542007. View Article : Google Scholar : PubMed/NCBI

6 

Diener C, Kuehner C, Brusniak W, Ubl B, Wessa M and Flor H: A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression. Neuroimage. 61:677–685. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Sawyer K, Corsentino E, Sachs-Ericsson N and Steffens DC: Depression, hippocampal volume changes, and cognitive decline in a clinical sample of older depressed outpatients and non-depressed controls. Aging Ment Health. 16:753–762. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Schiepers OJ, Wichers MC and Maes M: Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry. 29:201–217. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Slavich GM and Irwin MR: From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychol Bull. 140:774–815. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Oxenkrug GF: Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: The serotonin hypothesis revisited 40 years later. Isr J Psychiatry Relat Sci. 47:56–63. 2010.PubMed/NCBI

11 

Hage MP and Azar ST: The link between thyroid function and depression. J Thyroid Res. 2012:5906482012. View Article : Google Scholar : PubMed/NCBI

12 

Ross DA and Cetas JS: Steroid psychosis: A review for neurosurgeons. J Neurooncol. 109:439–447. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK and Lanctôt KL: A meta-analysis of cytokines in major depression. Biol Psychiatry. 67:446–457. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G and Aubry JM: Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 109:143–148. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato M, Watanabe H, Shinoda N, Okada S and Iyo M: Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry. 54:70–75. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Pedersen BK: Special feature for the Olympics: Effects of exercise on the immune system: Exercise and cytokines. Immunol Cell Biol. 78:532–535. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Chung S, Son GH and Kim K: Circadian rhythm of adrenal glucocorticoid: Its regulation and clinical implications. Biochim Biophys Acta. 1812:581–591. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Yamanishi K, Doe N, Sumida M, Watanabe Y, Yoshida M, Yamamoto H, Xu Y, Li W, Yamanishi H, Okamura H and Matsunaga H: Hepatocyte nuclear factor 4 alpha is a key factor related to depression and physiological homeostasis in the mouse brain. PLoS One. 10:e01190212015. View Article : Google Scholar : PubMed/NCBI

19 

Yamanishi K, Maeda S, Kuwahara-Otani S, Watanabe Y, Yoshida M, Ikubo K, Okuzaki D, El-Darawish Y, Li W, Nakasho K, et al: Interleukin-18-deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis. Transl Res. 173:101–114.e7. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP and Johnson JA: Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: Support for the amyloid hypothesis. J Neurosci. 24:7707–7717. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Yadav A, Kalita A, Dhillon S and Banerjee K: JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3. J Biol Chem. 280:31830–31840. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Zheng WH, Kar S and Quirion R: Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons. Mol Pharmacol. 62:225–233. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Padmanabhan J, Levy M, Dickson DW and Potter H: Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain. 129:3020–3034. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Tsirka SE, Rogove AD, Bugge TH, Degen JL and Strickland S: An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci. 17:543–552. 1997.PubMed/NCBI

25 

Donovan FM, Pike CJ, Cotman CW and Cunningham DD: Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci. 17:5316–5326. 1997.PubMed/NCBI

26 

Geiser F, Conrad R, Imbierowicz K, Meier C, Liedtke R, Klingmüller D, Oldenburg J and Harbrecht U: Coagulation activation and fibrinolysis impairment are reduced in patients with anxiety and depression when medicated with serotonergic antidepressants. Psychiatry Clin Neurosci. 65:518–525. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Schroeder V, Borner U, Gutknecht S, Schmid JP, Saner H and Kohler HP: Relation of depression to various markers of coagulation and fibrinolysis in patients with and without coronary artery disease. Eur J Cardiovasc Prev Rehabil. 14:782–787. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Kang HJ, Voleti B, Hajszan T, Rajkowska G, Stockmeier CA, Licznerski P, Lepack A, Majik MS, Jeong LS, Banasr M, et al: Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nat Med. 18:1413–1417. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Frye MA, Nassan M, Jenkins GD, Kung S, Veldic M, Palmer BA, Feeder SE, Tye SJ, Choi DS and Biernacka JM: Feasibility of investigating differential proteomic expression in depression: Implications for biomarker development in mood disorders. Transl Psychiatry. 5:e6892015. View Article : Google Scholar : PubMed/NCBI

30 

Lisowski P, Wieczorek M, Goscik J, Juszczak GR, Stankiewicz AM, Zwierzchowski L and Swiergiel AH: Effects of chronic stress on prefrontal cortex transcriptome in mice displaying different genetic backgrounds. J Mol Neurosci. 50:33–57. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Kang X, Song Z, McClain CJ, Kang YJ and Zhou Z: Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration. Am J Pathol. 172:916–925. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, et al: Control of pancreas and liver gene expression by HNF transcription factors. Science. 303:1378–1381. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Naiki T, Nagaki M, Shidoji Y, Kojima H, Imose M, Kato T, Ohishi N, Yagi K and Moriwaki H: Analysis of gene expression profile induced by hepatocyte nuclear factor 4alpha in hepatoma cells using an oligonucleotide microarray. J Biol Chem. 277:14011–14019. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Späth GF and Weiss MC: Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells. Mol Cell Biol. 17:1913–1922. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Costa RH, Van Dyke TA, Yan C, Kuo F and Darnell JE Jr: Similarities in transthyretin gene expression and differences in transcription factors: Liver and yolk sac compared to choroid plexus. Proc Natl Acad Sci USA. 87:6589–6593. 1990. View Article : Google Scholar : PubMed/NCBI

36 

Stankiewicz AM, Goscik J, Majewska A, Swiergiel AH and Juszczak GR: The effect of acute and chronic social stress on the hippocampal transcriptome in mice. PLoS One. 10:e01421952015. View Article : Google Scholar : PubMed/NCBI

37 

Wohleb ES, Powell ND, Godbout JP and Sheridan JF: Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J Neurosci. 33:13820–13833. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Li C, Li S, Jia C, Yang L, Song Z and Wang Y: Low concentration of S100A8/9 promotes angiogenesis-related activity of vascular endothelial cells: Bridges among inflammation, angiogenesis, and tumorigenesis? Mediators Inflamm. 2012:2485742012. View Article : Google Scholar : PubMed/NCBI

39 

Croce K, Gao H, Wang Y, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RR, Hogg N, Libby P and Simon DI: Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation. 120:427–436. 2009. View Article : Google Scholar : PubMed/NCBI

40 

de Seny D, Fillet M, Ribbens C, Marée R, Meuwis MA, Lutteri L, Chapelle JP, Wehenkel L, Louis E, Merville MP and Malaise M: Monomeric calgranulins measured by SELDI-TOF mass spectrometry and calprotectin measured by ELISA as biomarkers in arthritis. Clin Chem. 54:1066–1075. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Sinz A, Bantscheff M, Mikkat S, Ringel B, Drynda S, Kekow J, Thiesen HJ and Glocker MO: Mass spectrometric proteome analyses of synovial fluids and plasmas from patients suffering from rheumatoid arthritis and comparison to reactive arthritis or osteoarthritis. Electrophoresis. 23:3445–3456. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Trendelenburg G: Molecular regulation of cell fate in cerebral ischemia: Role of the inflammasome and connected pathways. J Cereb Blood Flow Metab. 34:1857–1867. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Nagareddy PR, Murphy AJ, Stirzaker RA, Hu Y, Yu S, Miller RG, Ramkhelawon B, Distel E, Westerterp M, Huang LS, et al: Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab. 17:695–708. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS, Brockway KS, Byrnes EJ, et al: Genome-wide atlas of gene expression in the adult mouse brain. Nature. 445:168–176. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Laughlin GA, McEvoy LK, Barrett-Connor E, Daniels LB and Ix JH: Fetuin-A, a new vascular biomarker of cognitive decline in older adults. Clin Endocrinol (Oxf). 81:134–140. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Biswas S, Sharma S, Saroha A, Bhakuni DS, Malhotra R, Zahur M, Oellerich M, Das HR and Asif AR: Identification of novel autoantigen in the synovial fluid of rheumatoid arthritis patients using an immunoproteomics approach. PLoS One. 8:e562462013. View Article : Google Scholar : PubMed/NCBI

47 

Mathews ST, Singh GP, Ranalletta M, Cintron VJ, Qiang X, Goustin AS, Jen KL, Charron MJ, Jahnen-Dechent W and Grunberger G: Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes. 51:2450–2458. 2002. View Article : Google Scholar : PubMed/NCBI

48 

You Z, Luo C, Zhang W, Chen Y, He J, Zhao Q, Zuo R and Wu Y: Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: Involvement in depression. Behav Brain Res. 225:135–141. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Lee SY, Jung YO, Kim DJ, Kang CM, Moon YM, Heo YJ, Oh HJ, Park SJ, Yang SH, Kwok SK, et al: IL-12p40 homodimer ameliorates experimental autoimmune arthritis. J Immunol. 195:3001–3010. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, et al: Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model. J Immunol. 186:4481–4489. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Sunahori K, Yamamura M, Yamana J, Takasugi K, Kawashima M, Yamamoto H, Chazin WJ, Nakatani Y, Yui S and Makino H: The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Res Ther. 8:R692006. View Article : Google Scholar : PubMed/NCBI

52 

Xu Y, Xu M, Bi Y, Song A, Huang Y, Liu Y, Wu Y, Chen Y, Wang W, Li X and Ning G: Serum fetuin-A is correlated with metabolic syndrome in middle-aged and elderly Chinese. Atherosclerosis. 216:180–186. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Ishibashi A, Ikeda Y, Ohguro T, Kumon Y, Yamanaka S, Takata H, Inoue M, Suehiro T and Terada Y: Serum fetuin-A is an independent marker of insulin resistance in Japanese men. J Atheroscler Thromb. 17:925–933. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ikubo K, Yamanishi K, Doe N, Hashimoto T, Sumida M, Watanabe Y, El‑Darawish Y, Li W, Okamura H, Yamanishi H, Yamanishi H, et al: Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis. Mol Med Rep 16: 301-309, 2017.
APA
Ikubo, K., Yamanishi, K., Doe, N., Hashimoto, T., Sumida, M., Watanabe, Y. ... Matsunaga, H. (2017). Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis. Molecular Medicine Reports, 16, 301-309. https://doi.org/10.3892/mmr.2017.6577
MLA
Ikubo, K., Yamanishi, K., Doe, N., Hashimoto, T., Sumida, M., Watanabe, Y., El‑Darawish, Y., Li, W., Okamura, H., Yamanishi, H., Matsunaga, H."Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis". Molecular Medicine Reports 16.1 (2017): 301-309.
Chicago
Ikubo, K., Yamanishi, K., Doe, N., Hashimoto, T., Sumida, M., Watanabe, Y., El‑Darawish, Y., Li, W., Okamura, H., Yamanishi, H., Matsunaga, H."Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis". Molecular Medicine Reports 16, no. 1 (2017): 301-309. https://doi.org/10.3892/mmr.2017.6577
Copy and paste a formatted citation
x
Spandidos Publications style
Ikubo K, Yamanishi K, Doe N, Hashimoto T, Sumida M, Watanabe Y, El‑Darawish Y, Li W, Okamura H, Yamanishi H, Yamanishi H, et al: Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis. Mol Med Rep 16: 301-309, 2017.
APA
Ikubo, K., Yamanishi, K., Doe, N., Hashimoto, T., Sumida, M., Watanabe, Y. ... Matsunaga, H. (2017). Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis. Molecular Medicine Reports, 16, 301-309. https://doi.org/10.3892/mmr.2017.6577
MLA
Ikubo, K., Yamanishi, K., Doe, N., Hashimoto, T., Sumida, M., Watanabe, Y., El‑Darawish, Y., Li, W., Okamura, H., Yamanishi, H., Matsunaga, H."Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis". Molecular Medicine Reports 16.1 (2017): 301-309.
Chicago
Ikubo, K., Yamanishi, K., Doe, N., Hashimoto, T., Sumida, M., Watanabe, Y., El‑Darawish, Y., Li, W., Okamura, H., Yamanishi, H., Matsunaga, H."Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis". Molecular Medicine Reports 16, no. 1 (2017): 301-309. https://doi.org/10.3892/mmr.2017.6577
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team