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Article Open Access

Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway

Corrigendum in: /10.3892/mmr.2022.12658
  • Authors:
    • Yongheng Bai
    • Cunzao Wu
    • Weilong Hong
    • Xing Zhang
    • Leping Liu
    • Bicheng Chen
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Transplantation, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 737-745
    |
    Published online on: May 25, 2017
       https://doi.org/10.3892/mmr.2017.6628
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Abstract

Sedum sarmentosum Bunge (SSBE) is a perennial plant widely distributed in Asian countries, and its extract is traditionally used for the treatment of certain inflammatory diseases. Our previous studies demonstrated that SSBE has marked renal anti‑fibrotic effects. However, the underlying molecular mechanisms remain to be fully elucidated. The present study identified that SSBE exerts its inhibitory effect on the myofibroblast phenotype and renal fibrosis via the hedgehog signaling pathway in vivo and in vitro. In rats with unilateral ureteral obstruction (UUO), SSBE administration reduced kidney injury and alleviated interstitial fibrosis by decreasing the levels of transforming growth factor (TGF)‑β1 and its receptor, and inhibiting excessive accumulation of extracellular matrix (ECM) components, including type I and III collagens. In addition, SSBE suppressed the expression of proliferating cell nuclear antigen, and this anti‑proliferative activity was associated with downregulation of hedgehog signaling activity in SSBE‑treated UUO kidneys. In cultured renal tubular epithelial cells (RTECs), recombinant TGF‑β1 activated hedgehog signaling, and resulted in induction of the myofibroblast phenotype. SSBE treatment inhibited the activation of hedgehog signaling and partially reversed the fibrotic phenotype in TGF‑β1‑treated RTECs. Similarly, aristolochic acid‑mediated upregulated activity of hedgehog signaling was reduced by SSBE treatment, and thereby led to the abolishment of excessive ECM accumulation. Therefore, these findings suggested that SSBE attenuates the myofibroblast phenotype and renal fibrosis via suppressing the hedgehog signaling pathway, and may facilitate the development of treatments for kidney fibrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Bai Y, Wu C, Hong W, Zhang X, Liu L and Chen B: Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway Corrigendum in /10.3892/mmr.2022.12658. Mol Med Rep 16: 737-745, 2017.
APA
Bai, Y., Wu, C., Hong, W., Zhang, X., Liu, L., & Chen, B. (2017). Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway Corrigendum in /10.3892/mmr.2022.12658. Molecular Medicine Reports, 16, 737-745. https://doi.org/10.3892/mmr.2017.6628
MLA
Bai, Y., Wu, C., Hong, W., Zhang, X., Liu, L., Chen, B."Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway Corrigendum in /10.3892/mmr.2022.12658". Molecular Medicine Reports 16.1 (2017): 737-745.
Chicago
Bai, Y., Wu, C., Hong, W., Zhang, X., Liu, L., Chen, B."Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway Corrigendum in /10.3892/mmr.2022.12658". Molecular Medicine Reports 16, no. 1 (2017): 737-745. https://doi.org/10.3892/mmr.2017.6628
Copy and paste a formatted citation
x
Spandidos Publications style
Bai Y, Wu C, Hong W, Zhang X, Liu L and Chen B: Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway Corrigendum in /10.3892/mmr.2022.12658. Mol Med Rep 16: 737-745, 2017.
APA
Bai, Y., Wu, C., Hong, W., Zhang, X., Liu, L., & Chen, B. (2017). Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway Corrigendum in /10.3892/mmr.2022.12658. Molecular Medicine Reports, 16, 737-745. https://doi.org/10.3892/mmr.2017.6628
MLA
Bai, Y., Wu, C., Hong, W., Zhang, X., Liu, L., Chen, B."Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway Corrigendum in /10.3892/mmr.2022.12658". Molecular Medicine Reports 16.1 (2017): 737-745.
Chicago
Bai, Y., Wu, C., Hong, W., Zhang, X., Liu, L., Chen, B."Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway Corrigendum in /10.3892/mmr.2022.12658". Molecular Medicine Reports 16, no. 1 (2017): 737-745. https://doi.org/10.3892/mmr.2017.6628
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