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Article

Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema

  • Authors:
    • Hongzhi Yu
    • Hongxia Shao
    • Qi Wu
    • Xin Sun
    • Li Li
    • Kuan Li
    • Xue Li
    • Yu Li
    • Qiuyang Zhang
    • Junping Wu
    • Huaiyong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, Tianjin Institute of Respiratory Diseases, Tianjin Haihe Hospital, Tianjin Medical University, Tianjin 300350, P.R. China, Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Tianjin Haihe Hospital, Tianjin Medical University, Tianjin 300350, P.R. China, Department of Basic Medicine, Tianjin Institute of Respiratory Diseases, Tianjin Haihe Hospital, Tianjin Medical University, Tianjin 300350, P.R. China
  • Pages: 881-886
    |
    Published online on: May 29, 2017
       https://doi.org/10.3892/mmr.2017.6642
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Abstract

Patients with respiratory overlap syndrome (OS), defined as concomitant chronic obstructive pulmonary disease and obstructive sleep apnea syndrome, may exhibit an increased blood concentration of ingested drugs. This poor elimination of drugs is primarily attributed to downregulated gene expression of the drug‑metabolizing cytochrome P450 enzymes (CYPs) in the liver. However, the underlying mechanisms of the decreased expression of CYPs in OS are poorly understood. In order to address this, a rat model of intermittent hypoxia with emphysema was evaluated in the present study, by analyzing liver gene expression using the reverse transcription‑quantitative polymerase chain reaction. Intermittent hypoxia and cigarette smoke exposure caused upregulation of hepatic inflammatory cytokines, while CYPs were downregulated. This downregulation of CYPs was associated with an increase in nuclear factor (NF)‑κB expression and a decrease in the expression of nuclear receptors pregnane X receptor, constitutive androstane receptor and glucocorticoid receptor, which are the upstream regulatory molecules of CYPs. The results of the present study indicated that, during the development of OS, systematic inflammatory reactions may downregulate hepatic CYP gene expression via the NF‑κB signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Yu H, Shao H, Wu Q, Sun X, Li L, Li K, Li X, Li Y, Zhang Q, Wu J, Wu J, et al: Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema. Mol Med Rep 16: 881-886, 2017.
APA
Yu, H., Shao, H., Wu, Q., Sun, X., Li, L., Li, K. ... Chen, H. (2017). Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema. Molecular Medicine Reports, 16, 881-886. https://doi.org/10.3892/mmr.2017.6642
MLA
Yu, H., Shao, H., Wu, Q., Sun, X., Li, L., Li, K., Li, X., Li, Y., Zhang, Q., Wu, J., Chen, H."Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema". Molecular Medicine Reports 16.1 (2017): 881-886.
Chicago
Yu, H., Shao, H., Wu, Q., Sun, X., Li, L., Li, K., Li, X., Li, Y., Zhang, Q., Wu, J., Chen, H."Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema". Molecular Medicine Reports 16, no. 1 (2017): 881-886. https://doi.org/10.3892/mmr.2017.6642
Copy and paste a formatted citation
x
Spandidos Publications style
Yu H, Shao H, Wu Q, Sun X, Li L, Li K, Li X, Li Y, Zhang Q, Wu J, Wu J, et al: Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema. Mol Med Rep 16: 881-886, 2017.
APA
Yu, H., Shao, H., Wu, Q., Sun, X., Li, L., Li, K. ... Chen, H. (2017). Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema. Molecular Medicine Reports, 16, 881-886. https://doi.org/10.3892/mmr.2017.6642
MLA
Yu, H., Shao, H., Wu, Q., Sun, X., Li, L., Li, K., Li, X., Li, Y., Zhang, Q., Wu, J., Chen, H."Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema". Molecular Medicine Reports 16.1 (2017): 881-886.
Chicago
Yu, H., Shao, H., Wu, Q., Sun, X., Li, L., Li, K., Li, X., Li, Y., Zhang, Q., Wu, J., Chen, H."Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema". Molecular Medicine Reports 16, no. 1 (2017): 881-886. https://doi.org/10.3892/mmr.2017.6642
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