Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes

Mi,Te; Luo,Changjiang; Hu,Yawei; Qu,Chuanqiang; Wang,Xiang; Guo,Shougang; Du,Yifeng

doi:10.3892/mmr.2017.6871

September-2017 Volume 16 Issue 3

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September-2017 Volume 16 Issue 3

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Article Open Access

Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes

Authors:
- Te Mi
- Changjiang Luo
- Yawei Hu
- Chuanqiang Qu
- Xiang Wang
- Shougang Guo
- Yifeng Du
View Affiliations / Copyright

Affiliations: Department of ICU, Jining No. 1 People's Hospital, Jining, Shandong 272000, P.R. China, Department of Neurology, Provincial Hospital Affiliated to Shandong University (South Branch), Jinan, Shandong 250002, P.R. China, Department of Neurosurgery, Affiliated Hospital of Jining Medical University Jining, Shandong 272029, P.R. China, Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China

Copyright: © Mi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2563-2569
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Published online on: June 28, 2017

https://doi.org/10.3892/mmr.2017.6871
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Abstract

Circular RNAs (circRNAs) are class of endogenous RNAs that have a role in the regulation of gene expression. The present study aimed to investigate the diagnostic value and role of circRNA in the pathogenesis of leukoaraiosis (LA). The present study performed Arraystar Human circRNA Array analysis of 6 samples from LA cases and 6 samples from control cases. Differentially expressed (DE) circRNAs between two samples were identified through fold‑change (>1.5‑fold) screening. Afterwards, based on DE circRNAs, the gene ontology (GO) analysis of upregulated DE genes identified from DE circRNAs demonstrated that DE genes were primarily associated with cellular metabolic processes, membrane‑bound organelles and binding. However, none were enriched in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Downregulated DE genes were enriched in cellular localization, cytoplasm and kinase binding. For the KEGG pathways, the downregulated DE genes were primarily associated with the insulin signaling pathway. The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes

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Abstract

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