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Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema

  • Authors:
    • Yong Wang
    • Hui Weng
    • Jian Fei Song
    • Yun Hua Deng
    • Shuang Li
    • Hong Bo Liu
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P.R. China, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P.R. China, Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Clinical Laboratory, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, Guangxi 541002, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2714-2720
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    Published online on: July 6, 2017
       https://doi.org/10.3892/mmr.2017.6942
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Abstract

High mobility group protein B1 (HMGB1) has been reported to serve important roles in various pathological conditions. Toll‑like receptor 4 (TLR4), as one of the HMGB1 receptors, has been reported to be involved in the development of certain inflammatory diseases by activating nuclear factor NF‑κ‑B (NF‑κB). However, there are few studies investigating the effects of HMGB1, TLR4 and NF‑κB on human inflammatory dermatoses. In the present study, the distribution and characteristics of HMGB1, TLR4 and NF‑κB p65 expression in psoriasis and atopic eczema (AE) were investigated. In addition, immunohistochemical analysis was performed to evaluate their expression and distribution in normal skin, and in patients with AE or psoria­sis. Spearman's correlation analysis was used to predicate their relevancy. The present study identified that the p65 level in epithelial nuclei in AE skin was increased compared with normal and psoriasis skin (P<0.01). The level of extracellular HMGB1 in AE skin was also increased compared with normal and psoriasis skin (P<0.01). Meanwhile, TLR4 expression on the epithelial membranes of AE skin was increased compared with psoriasis skin (P<0.01). Furthermore, the level of extracellular HMGB1 was positively correlated with epithelial membrane TLR4 (r=0.3856; P<0.05) and epithelial nuclear p65 (r=0.5894; P<0.01) in AE skin. These results indicated that the HMGB1‑TLR4‑NF‑κB signaling pathway is activated in AE and may account for its pathogenesis, but not in psoriasis. Therefore, HMGB1, TLR4 and NF‑κB p65 have the potential to be targets for the treatment of human inflammatory dermatoses, including AE.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Weng H, Song J, Deng Y, Li S and Liu H: Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema. Mol Med Rep 16: 2714-2720, 2017.
APA
Wang, Y., Weng, H., Song, J., Deng, Y., Li, S., & Liu, H. (2017). Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema. Molecular Medicine Reports, 16, 2714-2720. https://doi.org/10.3892/mmr.2017.6942
MLA
Wang, Y., Weng, H., Song, J., Deng, Y., Li, S., Liu, H."Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema". Molecular Medicine Reports 16.3 (2017): 2714-2720.
Chicago
Wang, Y., Weng, H., Song, J., Deng, Y., Li, S., Liu, H."Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema". Molecular Medicine Reports 16, no. 3 (2017): 2714-2720. https://doi.org/10.3892/mmr.2017.6942
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Weng H, Song J, Deng Y, Li S and Liu H: Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema. Mol Med Rep 16: 2714-2720, 2017.
APA
Wang, Y., Weng, H., Song, J., Deng, Y., Li, S., & Liu, H. (2017). Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema. Molecular Medicine Reports, 16, 2714-2720. https://doi.org/10.3892/mmr.2017.6942
MLA
Wang, Y., Weng, H., Song, J., Deng, Y., Li, S., Liu, H."Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema". Molecular Medicine Reports 16.3 (2017): 2714-2720.
Chicago
Wang, Y., Weng, H., Song, J., Deng, Y., Li, S., Liu, H."Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema". Molecular Medicine Reports 16, no. 3 (2017): 2714-2720. https://doi.org/10.3892/mmr.2017.6942
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