Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2017 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2017 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effects of marrubiin improve endometriosis through suppression of the expression of RANTES

  • Authors:
    • Xiao‑Hong Sun
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Nanhua Hospital Affiliated to Nanhua University, Hengyang, Hunan 421001, P.R. China
  • Pages: 3339-3344
    |
    Published online on: July 14, 2017
       https://doi.org/10.3892/mmr.2017.6969
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Marrubiin can improve blood and lymph microcirculation disturbance, and has pharmacological effects in myocardial protection, anti‑inflammation and anti‑oxidation. The aim of the present study was to evaluate the protective effects of marrubiin on endometriosis through suppression of the expression of regulated on activation, normal T cell expressed and secreted (RANTES). Endometriotic cells were implanted into the peritoneal cavity of mice, and these mice were injected estradiol benzoate (30 µg/kg) once each day for 14 days. The mice with endometriosis were then treated with 12, 25 or 50 mg/kg marrubiin. Reverse transcription‑quantitative polymerase chain reaction was used to assess the mRNA expression of RANTES, and western blot analysis was used to analyze the protein expression of RANTES, TNF‑α and PGE2. Inflammation factors were measured by ELISA. Treatment with marrubiin effectively improved lesion regression and inhibited toxicity in the mouse model of endometriosis. Marrubiin significantly inhibited endometrial lesions and monocyte chemotaxis in the mice with endometriosis, and reduced U937 cell migration. Calcium mobilization, levels of tumor necrosis factor‑α and the secretion of RANTES were effectively suppressed by marrubiin treatment. The calcium levels were effectively induced, whereas the protein expression of prostaglandin E2 (PGE2) and formation of thromboxane B2 (TXB2) were effectively inhibited by marrubiin treatment. These findings indicated that the protective effect of marrubiin improved endometriosis in the mice through the suppression of inflammation and downregulation of the expression of RANTES, followed by mediation of the levels of calcium, PGE2 and TXB2.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Singh AK, Chattopadhyay R, Chakravarty B and Chaudhury K: Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF. Reprod Toxicol. 42:116–124. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Yun BH, Jeon YE, Chon SJ, Park JH, Seo SK, Cho S, Choi YS, Lee JS and Lee BS: The Prognostic Value of Individual Adhesion Scores from the Revised American Fertility Society Classification System for Recurrent Endometriosis. Yonsei Med J. 56:1079–1086. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Kondi-Pafiti A, Papakonstantinou E, Iavazzo C, Grigoriadis C, Salakos N and Gregoriou O: Clinicopathological characteristics of ovarian carcinomas associated with endometriosis. Arch Gynecol Obstet. 285:479–483. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Wang KC, Chang WH, Lee WL, Huang N, Huang HY, Yen MS, Guo CY and Wang PH: An increased risk of epithelial ovarian cancer in Taiwanese women with a new surgico-pathological diagnosis of endometriosis. BMC Cancer. 14:8312014. View Article : Google Scholar : PubMed/NCBI

5 

Sakr S, Naqvi H, Komm B and Taylor HS: Endometriosis impairs bone marrow-derived stem cell recruitment to the uterus whereas bazedoxifene treatment leads to endometriosis regression and improved uterine stem cell engraftment. Endocrinology. 155:1489–1497. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Johnston JL, Reid H and Hunter D: Diagnosing endometriosis in primary care: Clinical update. Br J Gen Pract. 65:101–102. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Wang XQ, Yu J, Luo XZ, Shi YL, Wang Y, Wang L and Li DJ: The high level of RANTES in the ectopic milieu recruits macrophages and induces their tolerance in progression of endometriosis. J Mol Endocrinol. 45:291–299. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Yang Y, Zhang X, Zhou C, Huang X, Lin J and Xu H: Elevated immunoreactivity of RANTES and CCR1 correlate with the severity of stages and dysmenorrhea in women with deep infiltrating endometriosis. Acta Histochem. 115:434–439. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Hornung D, Ryan IP, Chao VA, Vigne JL, Schriock ED and Taylor RN: Immunolocalization and regulation of the chemokine RANTES in human endometrial and endometriosis tissues and cells. J Clin Endocrinol Metab. 82:1621–1628. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Mnonopi N, Levendal RA, Mzilikazi N and Frost CL: Marrubiin, a constituent of Leonotis leonurus, alleviates diabetic symptoms. Phytomedicine. 19:488–493. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Stulzer HK, Tagliari MP, Zampirolo JA, Cechinel-Filho V and Schlemper V: Antioedematogenic effect of marrubiin obtained from Marrubium vulgare. J Ethnopharmacol. 108:379–384. 2006. View Article : Google Scholar : PubMed/NCBI

12 

De Jesus RA, Cechinel-Filho V, Oliveira AE and Schlemper V: Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgare. Phytomedicine. 7:111–115. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Knöss W, Reuter B and Zapp J: Biosynthesis of the labdane diterpene marrubiin in Marrubium vulgare via a non-mevalonate pathway. Biochem J. 326:449–454. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Vercellini P, Consonni D, Barbara G, Buggio L, Frattaruolo MP and Somigliana E: Adenomyosis and reproductive performance after surgery for rectovaginal and colorectal endometriosis: A systematic review and meta-analysis. Reprod Biomed Online. 28:704–713. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Palm F, Walter I, Budik S, Kolodziejek J, Nowotny N and Aurich C: Influence of different semen extenders and seminal plasma on PMN migration and on expression of IL-1beta, IL-6, TNF-alpha and COX-2 mRNA in the equine endometrium. Theriogenology. 70:843–851. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Wessels JM, Linton NF, Croy BA and Tayade C: A review of molecular contrasts between arresting and viable porcine attachment sites. Am J Reprod Immunol. 58:470–480. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Ghosh D and Sengupta J: Delineating the prime mover action of progesterone for endometrial receptivity in primates. Indian J Med Res. 140:(Suppl). S130–S136. 2014.PubMed/NCBI

18 

Abutorabi R, Baradaran A, Mostafavi F Sadat, Zarrin Y and Mardanian F: Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis. Int J Fertil Steril. 9:329–337. 2015.PubMed/NCBI

19 

Ozbilgin K, Turan A, Kahraman B, Atay C, Vatansever S, Uluer ET and Ozçakir T: Distribution of furin, TNF-α and TGF-β2 in the endometrium of missed abortion and voluntary first trimester termination cases. Anal Quant Cytopathol Histpathol. 37:123–133. 2015.PubMed/NCBI

20 

Lu D, Song H and Shi G: Anti-TNF-α treatment for pelvic pain associated with endometriosis. Cochrane Database Syst Rev. 28:CD0080882013.

21 

Agic A, Xu H, Rehbein M, Wolfler MM, Ebert AD and Hornung D: Cognate chemokine receptor 1 messenger ribonucleic acid expression in peripheral blood as a diagnostic test for endometriosis. Fertil Steril. 87:982–984. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Xu H, Schultze-Mosgau A, Agic A, Diedrich K, Taylor RN and Hornung D: Regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 in follicular fluid accumulate differentially in patients with and without endometriosis undergoing in vitro fertilization. Fertil Steril. 86:1616–1620. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Lebovic DI, Chao VA, Martini JF and Taylor RN: IL-1beta induction of RANTES (regulated upon activation, normal T cell expressed and secreted) chemokine gene expression in endometriotic stromal cells depends on a nuclear factor-kappaB site in the proximal promoter. J Clin Endocrinol Metab. 86:4759–4764. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Hornung D, Bentzien F, Wallwiener D, Kiesel L and Taylor RN: Chemokine bioactivity of RANTES in endometriotic and normal endometrial stromal cells and peritoneal fluid. Mol Hum Reprod. 7:163–168. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun XH: Protective effects of marrubiin improve endometriosis through suppression of the expression of RANTES. Mol Med Rep 16: 3339-3344, 2017.
APA
Sun, X. (2017). Protective effects of marrubiin improve endometriosis through suppression of the expression of RANTES. Molecular Medicine Reports, 16, 3339-3344. https://doi.org/10.3892/mmr.2017.6969
MLA
Sun, X."Protective effects of marrubiin improve endometriosis through suppression of the expression of RANTES". Molecular Medicine Reports 16.3 (2017): 3339-3344.
Chicago
Sun, X."Protective effects of marrubiin improve endometriosis through suppression of the expression of RANTES". Molecular Medicine Reports 16, no. 3 (2017): 3339-3344. https://doi.org/10.3892/mmr.2017.6969
Copy and paste a formatted citation
x
Spandidos Publications style
Sun XH: Protective effects of marrubiin improve endometriosis through suppression of the expression of RANTES. Mol Med Rep 16: 3339-3344, 2017.
APA
Sun, X. (2017). Protective effects of marrubiin improve endometriosis through suppression of the expression of RANTES. Molecular Medicine Reports, 16, 3339-3344. https://doi.org/10.3892/mmr.2017.6969
MLA
Sun, X."Protective effects of marrubiin improve endometriosis through suppression of the expression of RANTES". Molecular Medicine Reports 16.3 (2017): 3339-3344.
Chicago
Sun, X."Protective effects of marrubiin improve endometriosis through suppression of the expression of RANTES". Molecular Medicine Reports 16, no. 3 (2017): 3339-3344. https://doi.org/10.3892/mmr.2017.6969
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team