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Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells

  • Authors:
    • Tongfa Ju
    • Huicheng Jin
    • Rongchao Ying
    • Qi Xie
    • Chunhua Zhou
    • Daquan Gao
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal and Anal Surgery, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China, Department of Hematology, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Ju et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3194-3200
    |
    Published online on: July 14, 2017
       https://doi.org/10.3892/mmr.2017.6986
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Abstract

Colorectal carcinoma (CRC) is one of the most common types of malignancy worldwide. Recently, neoadjuvant chemotherapy has become an important treatment strategy for CRC. However, treatment frequently fails due to the development of chemoresistance, which is a major obstacle for positive prognosis. However, the underlying mechanisms of chemoresistance remain unclear. The present study assessed the functions of nucleus accumbens‑associated protein 1 (NAC1), an important transcriptional regulator, in CRC progression. Reverse transcription‑quantitative polymerase chain reaction, western blot analysis and immunohistochemistry were performed to detect the expression levels of NAC1. It was identified that NAC1 was significantly overexpressed in CRC compared with non‑tumorous tissues, indicating an oncogenic role. Following this, gain and loss of function analyses were performed in vitro to further investigate the function of NAC1. Cell viability and caspase‑3/7 activity assays were used to assess chemotherapy‑induced apoptosis. These results indicated that overexpression of NAC1 in CRC cells increased resistance to chemotherapy and inhibited apoptosis. Additionally, RNA interference‑mediated knockdown of NAC1 restored the chemosensitivity of CRC cells. Furthermore, mechanistic investigation revealed that NAC1 increased drug resistance via inducing homeobox A9 (HOXA9) expression, and that knockdown of HOXA9 abrogated NAC1‑induced drug resistance. In conclusion, the results of the present study demonstrated that NAC1 may be a critical factor in the develo­pment of chemoresistance, offering a potential novel target for the treatment of CRC.
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View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Shaukat A, Mongin SJ, Geisser MS, Lederle FA, Bond JH, Mandel JS and Church TR: Long-term mortality after screening for colorectal cancer. N Engl J Med. 369:1106–1114. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Schrag D, Weiser MR, Goodman KA, Gonen M, Hollywood E, Cercek A, Reidy-Lagunes DL, Gollub MJ, Shia J, Guillem JG, et al: Neoadjuvant chemotherapy without routine use of radiation therapy for patients with locally advanced rectal cancer: A pilot trial. J Clin Oncol. 32:513–518. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Bosset JF, Calais G, Mineur L, Maingon P, Stojanovic-Rundic S, Bensadoun RJ, Bardet E, Beny A, Ollier JC, Bolla M, et al: Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: Long-term results of the EORTC 22921 randomised study. Lancet Oncol. 15:184–190. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Cecchin E, D'Andrea M, Lonardi S, Zanusso C, Pella N, Errante D, De Mattia E, Polesel J, Innocenti F and Toffoli G: A prospective validation pharmacogenomic study in the adjuvant setting of colorectal cancer patients treated with the 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen. Pharmacogenomics J. 13:403–409. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Tong M, Zheng W, Lu X, Ao L, Li X, Guan Q, Cai H, Li M, Yan H, Guo Y, et al: Identifying clinically relevant drug resistance genes in drug-induced resistant cancer cell lines and post-chemotherapy tissues. Oncotarget. 6:41216–41227. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Holohan C, Van Schaeybroeck S, Longley DB and Johnston PG: Cancer drug resistance: An evolving paradigm. Nat Rev Cancer. 13:714–726. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Y, Cheng Y, Ren X, Zhang L, Yap KL, Wu H, Patel R, Liu D, Qin ZH, Shih IM and Yang JM: NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response. Oncogene. 31:1055–1064. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Tsunoda K, Oikawa H, Tada H, Tatemichi Y, Muraoka S, Miura S, Shibazaki M, Maeda F, Takahashi K, Akasaka T, et al: Nucleus accumbens-associated 1 contributes to cortactin deacetylation and augments the migration of melanoma cells. J Invest Dermatol. 131:1710–1719. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Zhang Y, Cheng Y, Ren X, Hori T, Huber-Keener KJ, Zhang L, Yap KL, Liu D, Shantz L, Qin ZH, et al: Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis. Cancer Res. 72:4262–4275. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Jinawath N, Vasoontara C, Yap KL, Thiaville MM, Nakayama K, Wang TL and Shih IM: NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer through inactivating Gadd45 pathway. Oncogene. 28:1941–1948. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Nakayama K, Nakayama N, Davidson B, Sheu JJ, Jinawath N, Santillan A, Salani R, Bristow RE, Morin PJ, Kurman RJ, et al: A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. Proc Natl Acad Sci USA. 103:18739–18744. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Davidson B, Berner A, Trope' CG, Wang TL and Shih IeM: Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions. Hum Pathol. 38:1030–1036. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Zhang Y, Yang JW, Ren X and Yang JM: NAC1 and HMGB1 enter a partnership for manipulating autophagy. Autophagy. 7:1557–1558. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Okazaki K, Nakayama N, Nariai Y, Nakayama K, Miyazaki K, Maruyama R, Kato H, Kosugi S, Urano T and Sakashita G: Nuclear localization signal in a cancer-related transcriptional regulator protein NAC1. Carcinogenesis. 33:1854–1862. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Gao M, Wu RC, Herlinger AL, Yap K, Kim JW, Wang TL and Shih IeM: Identification of the NAC1-regulated genes in ovarian cancer. Am J Pathol. 184:133–140. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Wu PH, Hung SH, Ren T, Shih IeM and Tseng Y: Cell cycle-dependent alteration in NAC1 nuclear body dynamics and morphology. Phys Biol. 8:0150052011. View Article : Google Scholar : PubMed/NCBI

18 

Larochelle A, Choi U, Shou Y, Naumann N, Loktionova NA, Clevenger JR, Krouse A, Metzger M, Donahue RE, Kang E, et al: In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. J Clin Invest. 119:1952–1963. 2009.PubMed/NCBI

19 

Shah N and Sukumar S: The Hox genes and their roles in oncogenesis. Nat Rev Cancer. 10:361–371. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Hayashida T, Takahashi F, Chiba N, Brachtel E, Takahashi M, Godin-Heymann N, Gross KW, Vivanco Md, Wijendran V, Shioda T, et al: HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis. Proc Natl Acad Sci USA. 107:1100–1105. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Wang Z, Iwasaki M, Ficara F, Lin C, Matheny C, Wong SH, Smith KS and Cleary ML: GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. Cancer Cell. 17:597–608. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Aberdam D, Negreanu V, Sachs L and Blatt C: The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts. Mol Cell Biol. 11:554–557. 1991. View Article : Google Scholar : PubMed/NCBI

23 

Cheng W, Liu J, Yoshida H, Rosen D and Naora H: Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med. 11:531–537. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Ko SY, Barengo N, Ladanyi A, Lee JS, Marini F, Lengyel E and Naora H: HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. J Clin Invest. 122:3603–3617. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Ferrarese R, Harsh GR VI, Yadav AK, Bug E, Maticzka D, Reichardt W, Dombrowski SM, Miller TE, Masilamani AP, Dai F, et al: Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. J Clin Invest. 124:2861–2876. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Zhou J, Zhan S, Tan W, Cheng R, Gong H and Zhu Q: P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth. Biochem Biophys Res Commun. 444:387–390. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Azmi AS, Bao B and Sarkar FH: Exosomes in cancer development, metastasis, and drug resistance: A comprehensive review. Cancer Metastasis Rev. 32:623–642. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Medina-Ramirez CM, Goswami S, Smirnova T, Bamira D, Benson B, Ferrick N, Segall J, Pollard JW and Kitsis RN: Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance. Cancer Res. 71:7705–7715. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Wei Y, Zou Z, Becker N, Anderson M, Sumpter R, Xiao G, Kinch L, Koduru P, Christudass CS, Veltri RW, et al: EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell. 154:1269–1284. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Yang WJ, Song MJ, Park EY, Lee JJ, Park JH, Park K, Park JH and Kim HP: Transcription factors Sp1 and Sp3 regulate expression of human ABCG2 gene and chemoresistance phenotype. Mol Cells. 36:368–375. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Breau MA, Wilkinson DG and Xu Q: A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling. Proc Natl Acad Sci USA. 110:16892–16897. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Gaspar N, Marshall L, Perryman L, Bax DA, Little SE, Viana-Pereira M, Sharp SY, Vassal G, Pearson AD, Reis RM, et al: MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature. Cancer Res. 70:9243–9252. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Brumatti G, Salmanidis M, Kok CH, Bilardi RA, Sandow JJ, Silke N, Mason K, Visser J, Jabbour AM, Glaser SP, et al: HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia. Oncotarget. 4:1933–1947. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Alharbi RA, Pettengell R, Pandha HS and Morgan R: The role of HOX genes in normal hematopoiesis and acute leukemia. Leukemia. 27:1000–1008. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Johansson AC, Ansell A, Jerhammar F, Lindh MB, Grénman R, Munck-Wikland E, Östman A and Roberg K: Cancer-associated fibroblasts induce matrix metalloproteinase-mediated cetuximab resistance in head and neck squamous cell carcinoma cells. Mol Cancer Res. 10:1158–1168. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ju T, Jin H, Ying R, Xie Q, Zhou C and Gao D: Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells. Mol Med Rep 16: 3194-3200, 2017.
APA
Ju, T., Jin, H., Ying, R., Xie, Q., Zhou, C., & Gao, D. (2017). Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells. Molecular Medicine Reports, 16, 3194-3200. https://doi.org/10.3892/mmr.2017.6986
MLA
Ju, T., Jin, H., Ying, R., Xie, Q., Zhou, C., Gao, D."Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells". Molecular Medicine Reports 16.3 (2017): 3194-3200.
Chicago
Ju, T., Jin, H., Ying, R., Xie, Q., Zhou, C., Gao, D."Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells". Molecular Medicine Reports 16, no. 3 (2017): 3194-3200. https://doi.org/10.3892/mmr.2017.6986
Copy and paste a formatted citation
x
Spandidos Publications style
Ju T, Jin H, Ying R, Xie Q, Zhou C and Gao D: Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells. Mol Med Rep 16: 3194-3200, 2017.
APA
Ju, T., Jin, H., Ying, R., Xie, Q., Zhou, C., & Gao, D. (2017). Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells. Molecular Medicine Reports, 16, 3194-3200. https://doi.org/10.3892/mmr.2017.6986
MLA
Ju, T., Jin, H., Ying, R., Xie, Q., Zhou, C., Gao, D."Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells". Molecular Medicine Reports 16.3 (2017): 3194-3200.
Chicago
Ju, T., Jin, H., Ying, R., Xie, Q., Zhou, C., Gao, D."Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells". Molecular Medicine Reports 16, no. 3 (2017): 3194-3200. https://doi.org/10.3892/mmr.2017.6986
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