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Article

Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway

  • Authors:
    • Jian Cao
    • Huiling Li
    • Guangquan Liu
    • Suping Han
    • Pengfei Xu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004, P.R. China, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, P.R. China, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Nanjing Maternal and Child Health Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004, P.R. China
  • Pages: 3600-3605
    |
    Published online on: July 17, 2017
       https://doi.org/10.3892/mmr.2017.7024
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Abstract

Protein Jumonji (JARID2), a member of the family of JmjC domain-containing proteins, has been reported to serve an important role in tumor growth and metastasis. However, the expression pattern and role of JARID2 in ovarian cancer remains unclear. Therefore, in the present study, the role of JARID2 in ovarian cancer was investigated, as well as the underlying mechanisms. The results of the present study demonstrated that the expression of JARID2 is upregulated in human ovarian cancer cell lines. Furthermore, downregulation of JARID2 significantly suppressed proliferation, migration, invasion and epithelial‑mesenchymal transition in human ovarian cancer cells. Mechanistically, downregulation of JARID2 decreased the protein expression levels of phosphorylated phosphoinositide 3‑kinase (PI3K) and protein kinase B (Akt) in ovarian cancer cells. In conclusion the observations suggested that knockdown of JARID2 inhibited proliferation, migration and invasion in vitro through the inactivation of the PI3K/Akt signaling pathway. Therefore, JARID2 may represent a potential therapeutic target for the treatment of ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Cao J, Li H, Liu G, Han S and Xu P: Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway. Mol Med Rep 16: 3600-3605, 2017.
APA
Cao, J., Li, H., Liu, G., Han, S., & Xu, P. (2017). Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway. Molecular Medicine Reports, 16, 3600-3605. https://doi.org/10.3892/mmr.2017.7024
MLA
Cao, J., Li, H., Liu, G., Han, S., Xu, P."Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway". Molecular Medicine Reports 16.3 (2017): 3600-3605.
Chicago
Cao, J., Li, H., Liu, G., Han, S., Xu, P."Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway". Molecular Medicine Reports 16, no. 3 (2017): 3600-3605. https://doi.org/10.3892/mmr.2017.7024
Copy and paste a formatted citation
x
Spandidos Publications style
Cao J, Li H, Liu G, Han S and Xu P: Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway. Mol Med Rep 16: 3600-3605, 2017.
APA
Cao, J., Li, H., Liu, G., Han, S., & Xu, P. (2017). Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway. Molecular Medicine Reports, 16, 3600-3605. https://doi.org/10.3892/mmr.2017.7024
MLA
Cao, J., Li, H., Liu, G., Han, S., Xu, P."Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway". Molecular Medicine Reports 16.3 (2017): 3600-3605.
Chicago
Cao, J., Li, H., Liu, G., Han, S., Xu, P."Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway". Molecular Medicine Reports 16, no. 3 (2017): 3600-3605. https://doi.org/10.3892/mmr.2017.7024
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