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November-2017 Volume 16 Issue 5

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Article

High CCL5 expression is associated with osteosarcoma metastasis and poor prognosis of patients with osteosarcoma

  • Authors:
    • Kai Sun
    • Chen Gong
    • Hao Peng
    • Hongsong Fang
    • Jianlin Zhou
    • Jianping Li
    • Sen Chen
    • Huifeng Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 6953-6957
    |
    Published online on: September 11, 2017
       https://doi.org/10.3892/mmr.2017.7458
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Abstract

Osteosarcoma is the most common primary malignant tumor of the skeletal system and is characterized by an aggressive clinical course and high metastatic potential. Regulated upon Activation Normal T cell Expressed and Secreted, also termed C‑C motif chemokine ligand 5 (CCL5), is associated with metastasis and poor prognosis in various types of cancer. The aim of the current study was to investigate the association between CCL5 expression and clinicopathological features and prognosis in patients with osteosarcoma. Tissue microarrays and reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry were used to examine the expression of CCL5 in human osteosarcoma tissues. The prognostic value of CCL5 expression was evaluated by the Kaplan‑Meier method and Cox proportional hazards regression model. The rate of high CCL5 expression was significantly higher in metastatic osteosarcomas than in osteosarcomas without metastases. The overall survival rates (P=0.001) and the metastasis‑free survival rates (P<0.001) of the low CCL5 expression group were significantly higher than the CCL5 high expression group. Multivariate Cox regression analysis indicated that CCL5 expression had independent predictive value for the prognosis of patients with osteosarcoma. In conclusion, the data of the current study indicated that CCL5 may serve as a biomarker for prognosis of osteosarcoma, and may be a potential molecular target for osteosarcoma therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Sun K, Gong C, Peng H, Fang H, Zhou J, Li J, Chen S and Zheng H: High CCL5 expression is associated with osteosarcoma metastasis and poor prognosis of patients with osteosarcoma. Mol Med Rep 16: 6953-6957, 2017.
APA
Sun, K., Gong, C., Peng, H., Fang, H., Zhou, J., Li, J. ... Zheng, H. (2017). High CCL5 expression is associated with osteosarcoma metastasis and poor prognosis of patients with osteosarcoma. Molecular Medicine Reports, 16, 6953-6957. https://doi.org/10.3892/mmr.2017.7458
MLA
Sun, K., Gong, C., Peng, H., Fang, H., Zhou, J., Li, J., Chen, S., Zheng, H."High CCL5 expression is associated with osteosarcoma metastasis and poor prognosis of patients with osteosarcoma". Molecular Medicine Reports 16.5 (2017): 6953-6957.
Chicago
Sun, K., Gong, C., Peng, H., Fang, H., Zhou, J., Li, J., Chen, S., Zheng, H."High CCL5 expression is associated with osteosarcoma metastasis and poor prognosis of patients with osteosarcoma". Molecular Medicine Reports 16, no. 5 (2017): 6953-6957. https://doi.org/10.3892/mmr.2017.7458
Copy and paste a formatted citation
x
Spandidos Publications style
Sun K, Gong C, Peng H, Fang H, Zhou J, Li J, Chen S and Zheng H: High CCL5 expression is associated with osteosarcoma metastasis and poor prognosis of patients with osteosarcoma. Mol Med Rep 16: 6953-6957, 2017.
APA
Sun, K., Gong, C., Peng, H., Fang, H., Zhou, J., Li, J. ... Zheng, H. (2017). High CCL5 expression is associated with osteosarcoma metastasis and poor prognosis of patients with osteosarcoma. Molecular Medicine Reports, 16, 6953-6957. https://doi.org/10.3892/mmr.2017.7458
MLA
Sun, K., Gong, C., Peng, H., Fang, H., Zhou, J., Li, J., Chen, S., Zheng, H."High CCL5 expression is associated with osteosarcoma metastasis and poor prognosis of patients with osteosarcoma". Molecular Medicine Reports 16.5 (2017): 6953-6957.
Chicago
Sun, K., Gong, C., Peng, H., Fang, H., Zhou, J., Li, J., Chen, S., Zheng, H."High CCL5 expression is associated with osteosarcoma metastasis and poor prognosis of patients with osteosarcoma". Molecular Medicine Reports 16, no. 5 (2017): 6953-6957. https://doi.org/10.3892/mmr.2017.7458
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