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Article

Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway

  • Authors:
    • Xu Yang
    • Sun Yang
    • Chen Hong
    • Wang Yu
    • Wang Guonian
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China, Department of Anesthesiology, Heilongjiang Province Hospital, Harbin, Heilongjiang 150000, P.R. China
  • Pages: 7829-7834
    |
    Published online on: September 19, 2017
       https://doi.org/10.3892/mmr.2017.7519
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Abstract

General anesthesia in patients with or at risk for neuronal injury remains challenging due to the neurotoxic effects of volatile anesthetics. One inhalation anesthetic, sevoflurane, induces neuronal damage, including neuroapoptosis, and learning and memory impairment. Panax Notoginseng Saponins (PNS) is the active ingredient of Sanqui and has been reported to exert neuroprotective effects. In the current study, the protective effect of PNS on sevoflurane‑induced nerve cell injury was explored. Cell proliferation was significantly reduced in a dose‑dependent manner following stimulation with sevoflurane. Furthermore, cell apoptosis and the protein expression of caspase‑3, caspase‑9 and Bax were significantly increased, while the expression of Bcl‑2 was decreased in the sevoflurane group compared with normal control. Furthermore, the protein level of Bace‑1, APP and Aβ were elevated in the sevoflurane group compared with the control group. By contrast, PNS treatment significantly reduced the neurotoxicity induced by sevoflurane. Additionally, sevoflurane reduced activation of the AKT signaling pathway, which was activated by PNS treatment. In conclusion, the results suggested that PNS attenuates sevoflurane‑induced neurotoxicity through by stimulating cell proliferation and inhibiting cell apoptosis. These effects were mediated, at least in part, by activating the AKT signaling pathway.
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1 

Moonesinghe SR, Mythen MG and Grocott MP: High-risk surgery: Epidemiology and outcomes. Anesth Analg. 112:891–901. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Schallner N, Ulbrich F, Engelstaedter H, Biermann J, Auwaerter V, Loop T and Goebel U: Isoflurane but not sevoflurane or desflurane aggravates injury to neurons in vitro and in vivo via p75NTR-NF-κB activation. Anesth Analg. 119:1429–1441. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Adamczyk S, Robin E, Simerabet M, Kipnis E, Tavernier B, Vallet B, Bordet R and Lebuffe G: Sevoflurane pre- and post-conditioning protect the brain via the mitochondrial K ATP channel. Br J Anaesth. 104:191–200. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Zheng H, Dong Y, Xu Z, Crosby G, Culley DJ, Zhang Y and Xie Z: Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice. Anesthesiology. 118:516–526. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Cascella M: Mechanisms underlying brain monitoring during anesthesia: Limitations, possible improvements, and perspectives. Korean J Anesthesiol. 69:113–120. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Zhou YF, Wang QX, Zhou HY and Chen G: Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells. Acta Pharmacol Sin. 37:580–588. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Si YC, Li Q, Xie CE, Niu X, Xia XH and Yu CY: Chinese herbs and their active ingredients for activating xue (blood) promote the proliferation and differentiation of neural stem cells and mesenchymal stem cells. Chin Med. 9:132014. View Article : Google Scholar : PubMed/NCBI

8 

Fan Y, Qiao Y, Huang J and Tang M: Protective effects of panax notoginseng saponins against high glucose-induced oxidative injury in rat retinal capillary endothelial cells. Evid Based Complement Alternat Med. 2016:53263822016. View Article : Google Scholar : PubMed/NCBI

9 

Yang BR, Cheung KK, Zhou X, Xie RF, Cheng PP, Wu S, Zhou ZY, Tang JY, Hoi PM, Wang YH and Lee SM: Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis. J Ethnopharmacol. 181:50–58. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Li B, Chen D, Li W and Xiao D: 20(S)-Protopanaxadiol saponins inhibit SKOV3 cell migration. Oncol Lett. 11:1693–1698. 2016.PubMed/NCBI

11 

Liu L, Zhu L, Zou Y, Liu W, Zhang X, Wei X, Hu B and Chen J: Panax notoginseng saponins promotes stroke recovery by influencing expression of Nogo-A, NgR and p75NGF, in vitro and in vivo. Biol Pharm Bull. 37:560–568. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Wang B and Li Y, Li XP and Li Y: Panax notoginseng saponins improve recovery after spinal cord transection by upregulating neurotrophic factors. Neural Regen Res. 10:1317–1320. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Clausen NG, Pedersen DA, Pedersen JK, Møller SE, Grosen D, Wehby GL, Christensen K and Hansen TG: Oral clefts and academic performance in adolescence: The impact of anesthesia-related neurotoxicity, timing of surgery and type of oral clefts. Cleft Palate Craniofac J. 54:371–380. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE and Xie Z: The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol. 66:620–631. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Quinn JJ, Loya F, Ma QD and Fanselow MS: Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioning. Hippocampus. 15:665–674. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Wang WY, Wu XM, Jia LJ, Zhang HH, Cai F, Mao H, Xu WC, Chen L, Zhang J and Hu SF: Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. Neuroscience. 313:199–212. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Hoffman AN, Malena RR, Westergom BP, Luthra P, Cheng JP, Aslam HA, Zafonte RD and Kline AE: Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience. Neurosci Lett. 431:226–230. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Satomoto M, Satoh Y, Terui K, Miyao H, Takishima K, Ito M and Imaki J: Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice. Anesthesiology. 110:628–637. 2009. View Article : Google Scholar : PubMed/NCBI

19 

CAST, . Randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke: CAST (Chinese Acute Stroke Trial) Collaborative Group. Lancet. 349:1641–1649. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Qin DX, Zou XL, Luo W, Zhang W, Zhang HT, Li XL, Zhang H, Wang XY and Wang TH: Expression of some neurotrophins in the spinal motoneurons after cord hemisection in adult rats. Neurosci Lett. 410:222–227. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Ning N, Dang X, Bai C, Zhang C and Wang K: Panax notoginsenoside produces neuroprotective effects in rat model of acute spinal cord ischemia-reperfusion injury. J Ethnopharmacol. 139:504–512. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE and Xie Z: The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem. 283:11866–11875. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Zhang E, Gao B, Yang L, Wu X and Wang Z: Notoginsenoside Ft1 promotes fibroblast proliferation via PI3K/Akt/mTOR signaling pathway and benefits wound healing in genetically diabetic mice. J Pharmacol Exp Ther. 356:324–332. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Yang S, Hong C, Yu W and Guonian W: Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway. Mol Med Rep 16: 7829-7834, 2017.
APA
Yang, X., Yang, S., Hong, C., Yu, W., & Guonian, W. (2017). Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway. Molecular Medicine Reports, 16, 7829-7834. https://doi.org/10.3892/mmr.2017.7519
MLA
Yang, X., Yang, S., Hong, C., Yu, W., Guonian, W."Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway". Molecular Medicine Reports 16.5 (2017): 7829-7834.
Chicago
Yang, X., Yang, S., Hong, C., Yu, W., Guonian, W."Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway". Molecular Medicine Reports 16, no. 5 (2017): 7829-7834. https://doi.org/10.3892/mmr.2017.7519
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Yang S, Hong C, Yu W and Guonian W: Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway. Mol Med Rep 16: 7829-7834, 2017.
APA
Yang, X., Yang, S., Hong, C., Yu, W., & Guonian, W. (2017). Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway. Molecular Medicine Reports, 16, 7829-7834. https://doi.org/10.3892/mmr.2017.7519
MLA
Yang, X., Yang, S., Hong, C., Yu, W., Guonian, W."Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway". Molecular Medicine Reports 16.5 (2017): 7829-7834.
Chicago
Yang, X., Yang, S., Hong, C., Yu, W., Guonian, W."Panax Notoginseng Saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway". Molecular Medicine Reports 16, no. 5 (2017): 7829-7834. https://doi.org/10.3892/mmr.2017.7519
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