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Article

Protective and therapeutic effects of Danhong injection on acute pancreatitis‑associated lung injury

  • Authors:
    • Qin Liu
    • Fuzhou Hua
    • Changqing Deng
    • Jing Zhang
    • Guohai Xu
    • Yanhui Hu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Gastroenterology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330000, P.R. China
  • Pages: 7603-7608
    |
    Published online on: September 19, 2017
       https://doi.org/10.3892/mmr.2017.7526
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Abstract

Lung functional impairment caused by acute pancreatitis (AP) is the primary contributor to AP‑associated mortality. Previous studies have reported that AP‑associated lung injury is associated with systemic inflammatory response syndrome and oxidative stress. In the present study, the protective effects of Danhong injection (DHI), a widely used Chinese Traditional Medicine preparation, on AP‑associated lung injury in rats was examined. The myeloperoxidase activity, malondiadelhyde level and superoxide dismutase activity determination demonstrated the anti‑inflammatory and anti‑oxidative properties of DHI. The results of western blotting and reverse‑transcription‑semi‑quantitative polymerase chain reaction indicated that DHI could protect rats against AP‑associated lung injury, and the protective effect was associated with the suppression of nuclear factor‑κB activation and cell adhesion molecule expression, and the reduction of neutrophil infiltration and oxidative stress levels. As demonstrated by HE staining, DHI inhibited the pancreas and lung tissue injury. Therefore, DHI could be a potential candidate for the treatment of patients with AP‑associated lung injury.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Q, Hua F, Deng C, Zhang J, Xu G and Hu Y: Protective and therapeutic effects of Danhong injection on acute pancreatitis‑associated lung injury. Mol Med Rep 16: 7603-7608, 2017.
APA
Liu, Q., Hua, F., Deng, C., Zhang, J., Xu, G., & Hu, Y. (2017). Protective and therapeutic effects of Danhong injection on acute pancreatitis‑associated lung injury. Molecular Medicine Reports, 16, 7603-7608. https://doi.org/10.3892/mmr.2017.7526
MLA
Liu, Q., Hua, F., Deng, C., Zhang, J., Xu, G., Hu, Y."Protective and therapeutic effects of Danhong injection on acute pancreatitis‑associated lung injury". Molecular Medicine Reports 16.5 (2017): 7603-7608.
Chicago
Liu, Q., Hua, F., Deng, C., Zhang, J., Xu, G., Hu, Y."Protective and therapeutic effects of Danhong injection on acute pancreatitis‑associated lung injury". Molecular Medicine Reports 16, no. 5 (2017): 7603-7608. https://doi.org/10.3892/mmr.2017.7526
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, Hua F, Deng C, Zhang J, Xu G and Hu Y: Protective and therapeutic effects of Danhong injection on acute pancreatitis‑associated lung injury. Mol Med Rep 16: 7603-7608, 2017.
APA
Liu, Q., Hua, F., Deng, C., Zhang, J., Xu, G., & Hu, Y. (2017). Protective and therapeutic effects of Danhong injection on acute pancreatitis‑associated lung injury. Molecular Medicine Reports, 16, 7603-7608. https://doi.org/10.3892/mmr.2017.7526
MLA
Liu, Q., Hua, F., Deng, C., Zhang, J., Xu, G., Hu, Y."Protective and therapeutic effects of Danhong injection on acute pancreatitis‑associated lung injury". Molecular Medicine Reports 16.5 (2017): 7603-7608.
Chicago
Liu, Q., Hua, F., Deng, C., Zhang, J., Xu, G., Hu, Y."Protective and therapeutic effects of Danhong injection on acute pancreatitis‑associated lung injury". Molecular Medicine Reports 16, no. 5 (2017): 7603-7608. https://doi.org/10.3892/mmr.2017.7526
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