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Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging

  • Authors:
    • Ji Hyeon Ahn
    • Seongkweon Hong
    • Joon Ha Park
    • In Hye Kim
    • Jeong Hwi Cho
    • Tae‑Kyeong Lee
    • Jae‑Chul Lee
    • Bai Hui Chen
    • Bich‑Na Shin
    • Eun Joo Bae
    • Yong Hwan Jeon
    • Young‑Myeong Kim
    • Moo‑Ho Won
    • Soo Young Choi
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea, Department of Surgery, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea, Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea, Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China, Department of Physiology, College of Medicine, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea, Department of Pediatrics, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Gangwon 24253, Republic of Korea, Department of Radiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24289, Republic of Korea, Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea
    Copyright: © Ahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7191-7198
    |
    Published online on: September 21, 2017
       https://doi.org/10.3892/mmr.2017.7573
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Abstract

Calbindin‑D28k (CB), calretinin (CR) and parvalbumin (PV), which regulate cytosolic free Ca2+ concentrations in neurons, are chemically expressed in γ‑aminobutyric acid (GABA)ergic neurons that regulate the degree of glutamatergic excitation and output of projection neurons. The present study investigated age‑associated differences in CB, CR and PV immunoreactivities in the somatosensory cortex in three species (mice, rats and gerbils) of young (1 month), adult (6 months) and aged (24 months) rodents, using immunohistochemistry and western blotting. Abundant CB‑immunoreactive neurons were distributed in layers II and III, and age‑associated alterations in their number were different according to the species. CR‑immunoreactive neurons were not abundant in all layers; however, the number of CR‑immunoreactive neurons was the highest in all adult species. Many PV‑immunoreactive neurons were identified in all layers, particularly in layers II and III, and they increased in all layers with age in all species. The present study demonstrated that the distribution pattern of CB‑, CR‑ and PV‑containing neurons in the somatosensory cortex were apparently altered in number with normal aging, and that CB and CR exhibited a tendency to decrease in aged rodents, whereas PV tended to increase with age. These results indicate that CB, CR and PV are markedly altered in the somatosensory cortex, and this change may be associated with normal aging. These findings may aid the elucidation of the mechanisms of aging and geriatric disease.
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Copy and paste a formatted citation
Spandidos Publications style
Ahn JH, Hong S, Park JH, Kim IH, Cho JH, Lee TK, Lee JC, Chen BH, Shin BN, Bae EJ, Bae EJ, et al: Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging. Mol Med Rep 16: 7191-7198, 2017.
APA
Ahn, J.H., Hong, S., Park, J.H., Kim, I.H., Cho, J.H., Lee, T. ... Choi, S.Y. (2017). Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging. Molecular Medicine Reports, 16, 7191-7198. https://doi.org/10.3892/mmr.2017.7573
MLA
Ahn, J. H., Hong, S., Park, J. H., Kim, I. H., Cho, J. H., Lee, T., Lee, J., Chen, B. H., Shin, B., Bae, E. J., Jeon, Y. H., Kim, Y., Won, M., Choi, S. Y."Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging". Molecular Medicine Reports 16.5 (2017): 7191-7198.
Chicago
Ahn, J. H., Hong, S., Park, J. H., Kim, I. H., Cho, J. H., Lee, T., Lee, J., Chen, B. H., Shin, B., Bae, E. J., Jeon, Y. H., Kim, Y., Won, M., Choi, S. Y."Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging". Molecular Medicine Reports 16, no. 5 (2017): 7191-7198. https://doi.org/10.3892/mmr.2017.7573
Copy and paste a formatted citation
x
Spandidos Publications style
Ahn JH, Hong S, Park JH, Kim IH, Cho JH, Lee TK, Lee JC, Chen BH, Shin BN, Bae EJ, Bae EJ, et al: Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging. Mol Med Rep 16: 7191-7198, 2017.
APA
Ahn, J.H., Hong, S., Park, J.H., Kim, I.H., Cho, J.H., Lee, T. ... Choi, S.Y. (2017). Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging. Molecular Medicine Reports, 16, 7191-7198. https://doi.org/10.3892/mmr.2017.7573
MLA
Ahn, J. H., Hong, S., Park, J. H., Kim, I. H., Cho, J. H., Lee, T., Lee, J., Chen, B. H., Shin, B., Bae, E. J., Jeon, Y. H., Kim, Y., Won, M., Choi, S. Y."Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging". Molecular Medicine Reports 16.5 (2017): 7191-7198.
Chicago
Ahn, J. H., Hong, S., Park, J. H., Kim, I. H., Cho, J. H., Lee, T., Lee, J., Chen, B. H., Shin, B., Bae, E. J., Jeon, Y. H., Kim, Y., Won, M., Choi, S. Y."Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging". Molecular Medicine Reports 16, no. 5 (2017): 7191-7198. https://doi.org/10.3892/mmr.2017.7573
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