miR‑455‑5p promotes cell invasion and migration in breast cancer

  • Authors:
    • Tuerxunjiang Aili
    • Xuelaiti Paizula
    • Aisikeer Ayoufu
  • View Affiliations

  • Published online on: November 16, 2017     https://doi.org/10.3892/mmr.2017.8101
  • Pages: 1825-1832
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Abstract

MicroRNA (miR)‑455‑5p has been identified as a biomarker for various types of cancer and may therefore be involved in the regulation of cancer development and progression. However, the specific role and function of miR‑455‑5p in breast cancer remains unclear. The present study explored the expression levels and function of miR‑455‑5p in breast cancer. The results from reverse transcription‑quantitative polymerase chain reaction analysis revealed that miR‑455‑5p was significantly upregulated in breast cancer. Clinically, increased expression of miR‑455‑5p predicted a poor survival rate and miR‑455‑5p was identified as one of the independent prognostic factors for breast cancer patients. Furthermore, results from wound healing and Transwell assays revealed that miR‑455‑5p accelerated invasiveness and migration capabilities of breast cancer cells. In addition, programmed cell death 4 was identified as a downstream target of miR‑455‑5p and its expression was observed to be negatively regulated by miR‑455‑5p. Overall, miR‑455‑5p may function as an oncogene in breast cancer, and may therefore be used as a prognostic marker for breast cancer patients.
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January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Aili T, Paizula X and Ayoufu A: miR‑455‑5p promotes cell invasion and migration in breast cancer. Mol Med Rep 17: 1825-1832, 2018
APA
Aili, T., Paizula, X., & Ayoufu, A. (2018). miR‑455‑5p promotes cell invasion and migration in breast cancer. Molecular Medicine Reports, 17, 1825-1832. https://doi.org/10.3892/mmr.2017.8101
MLA
Aili, T., Paizula, X., Ayoufu, A."miR‑455‑5p promotes cell invasion and migration in breast cancer". Molecular Medicine Reports 17.1 (2018): 1825-1832.
Chicago
Aili, T., Paizula, X., Ayoufu, A."miR‑455‑5p promotes cell invasion and migration in breast cancer". Molecular Medicine Reports 17, no. 1 (2018): 1825-1832. https://doi.org/10.3892/mmr.2017.8101