Effect of Atractylodes macrocephala rhizoma on isoproterenol‑induced ventricular remodeling in rats

  • Authors:
    • Xiao‑Hua Cui
    • Hui‑Lin Wang
    • Rong Wu
    • Ping‑An Yao
    • Ke‑Zhao Wei
    • Jian‑Ping Gao
  • View Affiliations

  • Published online on: November 21, 2017     https://doi.org/10.3892/mmr.2017.8121
  • Pages: 2607-2613
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Abstract

Myocardial infarction (MI) is the primary cause of ventricular remodeling (VR). The aim of the present study was to determine the effect of Atractylodis macrocephalae rhizoma (AMR) on VR induced by isoproterenol (ISO) in rats. Male Sprague Dawley rats were randomly divided into the normal control, ISO‑induced and AMR groups. Rats in the ISO‑induced and AMR groups were subcutaneously injected with 85 mg/kg/day ISO for two consecutive days. Compared with the ISO‑induced group, AMR normalized the levels of hemodynamic parameters, markedly attenuated myocardial pathological damage, decreased the level of N‑terminal prohormone of brain natriuretic peptide, and inhibited cardiac hypertrophy and myocardial fibrosis. In addition, AMR inhibited oxidative stress and activation of the rennin‑angiotensin‑aldosterone system (RAAS) when compared with the ISO‑induced group. The results of the present study suggest that AMR may reverse VR via its antioxidative effect and inhibition of RAAS activation.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Cui XH, Wang HL, Wu R, Yao PA, Wei KZ and Gao JP: Effect of Atractylodes macrocephala rhizoma on isoproterenol‑induced ventricular remodeling in rats. Mol Med Rep 17: 2607-2613, 2018.
APA
Cui, X., Wang, H., Wu, R., Yao, P., Wei, K., & Gao, J. (2018). Effect of Atractylodes macrocephala rhizoma on isoproterenol‑induced ventricular remodeling in rats. Molecular Medicine Reports, 17, 2607-2613. https://doi.org/10.3892/mmr.2017.8121
MLA
Cui, X., Wang, H., Wu, R., Yao, P., Wei, K., Gao, J."Effect of Atractylodes macrocephala rhizoma on isoproterenol‑induced ventricular remodeling in rats". Molecular Medicine Reports 17.2 (2018): 2607-2613.
Chicago
Cui, X., Wang, H., Wu, R., Yao, P., Wei, K., Gao, J."Effect of Atractylodes macrocephala rhizoma on isoproterenol‑induced ventricular remodeling in rats". Molecular Medicine Reports 17, no. 2 (2018): 2607-2613. https://doi.org/10.3892/mmr.2017.8121