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Article Open Access

Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism

  • Authors:
    • Ting‑Jun Jiang
    • Xue‑Liang Cao
    • Sha Luan
    • Wan‑Hui Cui
    • Si‑Huang Qiu
    • Yi‑Chao Wang
    • Chang‑Jiu Zhao
    • Peng Fu
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, The Fourth Clinical Medical College of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Harbin Orthopedics Hospital, Harbin, Heilongjiang 150080, P.R. China, Department of Nuclear Medicine, 1st Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2137-2144
    |
    Published online on: November 27, 2017
       https://doi.org/10.3892/mmr.2017.8154
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Abstract

The current study observed the percentage of peripheral blood (PB) CD4+CD25+ regulatory T cells (Tregs) and the influence of CD4+CD25+ Tregs on the proliferation of naïve CD4 T cells in patients with hyperthyroidism. Furthermore, preliminary discussions are presented on the action mechanism of CD4+CD25+ Tregs on hyperthyroidism attacks. The present study identified that compared with the percentage of PB CD4+CD25+ Tregs in healthy control subjects, no significant changes were observed in the percentage of PB CD4+CD25+ Tregs in patients with hyperthyroidism (P>0.05). For patients with hyperthyroidism, CD4+CD25+ Tregs exhibited significantly reduced inhibition of the proliferation of naïve CD4 T cells and decreased secretion capacity on the cytokines of CD4 T cells, compared with those of healthy control subjects (P<0.05). In addition, it was demonstrated that thyroid function of patients with hyperthyroidism was significantly improved (P<0.05) subsequent to receiving medication. Compared with the percentage of PB CD4+CD25+ Tregs in patients with hyperthyroidism before treatment, no significant changes were observed in the percentage of PB CD4+CD25+ Tregs in hyperthyroidism patients following treatment (P>0.05). In the patients with hyperthyroidism, following treatment, CD4+CD25+ Tregs exhibited significantly increased inhibition of the proliferation of naïve CD4 T cells and increased secretion capacity of CD4 T cell cytokines, compared with those of the patients with hyperthyroidism prior to treatment (P<0.05). PB CD4+CD25+ Tregs function was decreased in patients with hyperthyroidism, and its non‑proportional decrease may be closely associated with the occurrence and progression of hyperthyroidism.
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1 

Vanderpump MPJ: The epidemiology of thyroid disease. Br Med Bull. 99:39–51. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Mao C, Wang S, Xiao Y, Xu J, Jiang Q, Jin M, Jiang X, Guo H, Ning G and Zhang Y: Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease. J Immunol. 186:4734–4743. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Klatka M, Kaszubowska L, Grywalska E, Wasiak M, Szewczyk L, Foerster J, Cyman M and Rolinski J: Treatment of Graves' disease with methimazole in children alters the proliferation of Treg cells and CD3+ T lymphocytes. Folia Histochem Cytobiol. 52:69–77. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Hamari S, Kirveskoski T, Glumoff V, Kulmala P, Simell O, Knip M and Veijola R: Analyses of regulatory CD4+ CD25+ FOXP3+ T cells and observations from peripheral T cell subpopulation markers during the development of type 1 diabetes in children. Scand J Immunol. 83:279–287. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Legorreta-Haquet MV, Chávez-Rueda K, Chávez-Sánchez L, Cervera-Castillo H, Zenteno-Galindo E, Barile-Fabris L, Burgos-Vargas R, Álvarez-Hernández E and Blanco-Favela F: Function of treg cells decreased in patients with systemic lupus erythematosus due to the effect of prolactin. Medicine (Baltimore). 95:e23842016. View Article : Google Scholar : PubMed/NCBI

6 

Hu Y, Tian W, Zhang LL, Liu H, Yin GP, He BS and Mao XM: Function of regulatory T-cells improved by dexamethasone in Graves' disease. Eur J Endocrinol. 166:641–646. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Saitoh O and Nagayama Y: Regulation of Graves' hyperthyroidism with naturally occurring CD4+CD25+ regulatory T cells in a mouse model. Endocrinology. 147:2417–2422. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Nagayama Y, Horie I, Saitoh O, Nakahara M and Abiru N: CD4+CD25+ naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune thyroiditis in NOD-H2h4 mice. J Autoimmun. 29:195–202. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Mao C, Wang S, Xiao Y, Xu J, Jiang Q, Jin M, Jiang X, Guo H, Ning G and Zhang Y: Impairment of regulatory capacity of CD4+ CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease. J Immunol. 186:4734–4743. 2011. View Article : Google Scholar : PubMed/NCBI

10 

He K, Hu Y and Mao X: Abnormal proportions of immune regulatory cells and their subsets in peripheral blood of patients with Graves' disease. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 30:1190–1193. 2014.(In Chinese). PubMed/NCBI

11 

Lantz M, Calissendorff J, Träisk F, Tallstedt L, Planck T, Törring O, Hallengren B and Åsman P: Adjuvant treatment of graves' disease with diclofenac: Safety, effects on ophthalmopathy and antibody concentrations. Eur Thyroid J. 5:50–56. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Chen JF, Gao J, Zhang D, Wang ZH and Zhu JY: CD4+Foxp3+ regulatory T cells converted by rapamycin from peripheral CD4+CD25(−) naive T cells display more potent regulatory ability in vitro. Chin Med J (Engl). 123:942–948. 2010.PubMed/NCBI

13 

Singhal N, Praveen VP, Bhavani N, Menon AS, Menon U, Abraham N, Kumar H, JayKunmar RV, Nair V, Sundaram S and Sundaram P: Technetium uptake predicts remission and relapse in Grave's disease patients on antithyroid drugs for at least 1 year in South Indian subjects. Indian J Endocrinol Metab. 20:157–161. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Allencherril J and Birnbaum I: Heart failure in thyrotoxic cardiomopathy: Extracorporeal membrane oxygenation treatment for graves' disease. J Extra Corpor Technol. 47:231–232. 2015.PubMed/NCBI

15 

Kaaroud H, Oueslati I, Harzallah A, Ben Nacef I, Khiari K and Ben Hamida F: Benzylthiouracil induced ANCA associated glomerulonephritis in patients with graves' disease. Tunis Med. 93:696–701. 2015.PubMed/NCBI

16 

Sasazuki T, Inoko H, Morishima S and Morishima Y: Gene map of the HLA region, graves' disease and hshimoto thyroiditis, and hematopoietic stem cell transplantation. Adv Immunol. 129:175–249. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Côté-Bigras S, Tran V, Turcotte S, Rola-Pleszczynski M, Verrerult J and Rottembourg D: Impaired immune regulation after radioiodine therapy for Graves' disease and the protective effect of Methimazole. Endocrine. 52:587–596. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Wei Y, Zheng D, Li X, Zhou W, Qian Y, Ming C and Shi B: Infusion of dendritic cells carrying donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light induces CD19+IL-10+ regulatory B cells and promotes skin allograft survival. Transplant Proc. 46:pp. 3641–3646. 2014; View Article : Google Scholar : PubMed/NCBI

19 

Li Q, Guo Z, Xu X, Xia X and Cao X: Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammation. Eur J Immunol. 38:2751–2761. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Peng G, Wang HY, Peng W, Kiniwa Y, Seo KH and Wang RF: Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway. Immunity. 27:334–348. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Mao XM, Li HQ, Li Q, Li DM, Xie XJ, Yin GP, Zhang P, Xu XH, Wu JD, Chen SW and Wang SK: Prevention of relapse of Graves' disease by treatment with an intrathyroid injection of dexamethasone. J Clin Endocrinol Metab. 94:4984–4991. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang TJ, Cao XL, Luan S, Cui WH, Qiu SH, Wang YC, Zhao CJ and Fu P: Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism. Mol Med Rep 17: 2137-2144, 2018.
APA
Jiang, T., Cao, X., Luan, S., Cui, W., Qiu, S., Wang, Y. ... Fu, P. (2018). Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism. Molecular Medicine Reports, 17, 2137-2144. https://doi.org/10.3892/mmr.2017.8154
MLA
Jiang, T., Cao, X., Luan, S., Cui, W., Qiu, S., Wang, Y., Zhao, C., Fu, P."Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism". Molecular Medicine Reports 17.2 (2018): 2137-2144.
Chicago
Jiang, T., Cao, X., Luan, S., Cui, W., Qiu, S., Wang, Y., Zhao, C., Fu, P."Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism". Molecular Medicine Reports 17, no. 2 (2018): 2137-2144. https://doi.org/10.3892/mmr.2017.8154
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang TJ, Cao XL, Luan S, Cui WH, Qiu SH, Wang YC, Zhao CJ and Fu P: Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism. Mol Med Rep 17: 2137-2144, 2018.
APA
Jiang, T., Cao, X., Luan, S., Cui, W., Qiu, S., Wang, Y. ... Fu, P. (2018). Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism. Molecular Medicine Reports, 17, 2137-2144. https://doi.org/10.3892/mmr.2017.8154
MLA
Jiang, T., Cao, X., Luan, S., Cui, W., Qiu, S., Wang, Y., Zhao, C., Fu, P."Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism". Molecular Medicine Reports 17.2 (2018): 2137-2144.
Chicago
Jiang, T., Cao, X., Luan, S., Cui, W., Qiu, S., Wang, Y., Zhao, C., Fu, P."Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism". Molecular Medicine Reports 17, no. 2 (2018): 2137-2144. https://doi.org/10.3892/mmr.2017.8154
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