Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region

  • Authors:
    • Bing Chun Yan
    • Jie Wang
    • Jianwen Cao
    • Moo‑Ho Won
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese and Western Medicine, Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou, Jiangsu 225001, P.R. China, Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 200‑701, Republic of Korea
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 3055-3061
    |
    Published online on: December 11, 2017
       https://doi.org/10.3892/mmr.2017.8243
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Insulin-like growth factor 1 (IGF-1) is a well-known growth factor with well-defined neuroprotective effects against cerebral ischemia. However, the age‑dependent differences in the expression of IGF‑1 and its receptor (IGF‑1R) in the brain following transient cerebral ischemia (TCI) have not been elucidated. In the present study, the differences in IGF‑1 and IGF‑1R in the gerbil hippocampal CA1 region of young and adult gerbils 5 min following TCI were determined. Seven days following TCI, the neuronal death in the hippocampal CA1 region of young gerbils was significantly less than that observed in adult gerbils. In addition, the immunoreactivity, and levels of IGF‑1 and IGF‑1R in the CA1 region of the normal young were higher than those in the normal adult. Four days following TCI, the immunoreactivity, and protein levels of IGF‑1 and IGF‑1R were markedly decreased in the adult group. By contrast, in the young group, the immunoreactivity and expression levels were much greater than those in the adult group. However, 7 days following TCI, all immunoreactivity and expression levels were markedly decreased when compared with those in the normal adult and young groups. In addition, the immunoreactivity and expression levels in the young groups were significantly higher than those of the adult groups. In conclusion, the present study demonstrated that the higher and sustained expression of IGF‑1 and IGF‑1R in the young gerbil hippocampal CA1 region following TCI may be associated with the reduced neuronal death compared to that in the adults.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Park SM, Lee JC, Chen BH, Shin BN, Cho JH, Kim IH, Park JH, Won MH, Ahn JH, Tae HJ, et al: Difference in transient ischemia-induced neuronal damage and glucose transporter-1 immunoreactivity in the hippocampus between adult and young gerbils. Iran J Basic Med Sci. 19:521–528. 2016.PubMed/NCBI

2 

Bae EJ, Chen BH, Yan BC, Shin BN, Cho JH, Kim IH, Ahn JH, Lee JC, Tae HJ, Hong S, et al: Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus. Neural Regen Res. 10:944–950. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Lee JC, Tae HJ, Chen BH, Cho JH, Kim IH, Ahn JH, Park JH, Shin BN, Lee HY, Cho YS, et al: Failure in neuroprotection of remote limb ischemic postconditioning in the hippocampus of a gerbil model of transient cerebral ischemia. J Neurol Sci. 358:377–384. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Araki T, Kato H and Kogure K: Selective neuronal vulnerability following transient cerebral ischemia in the gerbil: Distribution and time course. Acta Neurol Scand. 80:548–553. 1989. View Article : Google Scholar : PubMed/NCBI

5 

Domoráková I, Burda J, Mechírová E and Feriková M: Mapping of rat hippocampal neurons with NeuN after ischemia/reperfusion and Ginkgo biloba extract (EGb 761) pretreatment. Cell Mol Neurobiol. 26:1193–1204. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Kirino T: Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:57–69. 1982. View Article : Google Scholar : PubMed/NCBI

7 

Oguro K, Miyawaki T, Yokota H, Kato K, Kamiya T, Katayama Y, Fukaya M, Watanabe M and Shimazaki K: Upregulation of GluR2 decreases intracellular Ca2+ following ischemia in developing gerbils. Neurosci Lett. 364:101–105. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Yan BC, Park JH, Ahn JH, Lee YJ, Lee TH, Lee CH, Cho JH, Kim MJ, Kim TY, Kang IJ and Won MH: Comparison of the immunoreactivity of Trx2/Prx3 redox system in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia. Neurochem Res. 37:1019–1030. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Kartal Ö, Aydınöz S, Kartal AT, Kelestemur T, Caglayan AB, Beker MC, Karademir F, Süleymanoğlu S, Kul M, Yulug B and Kilic E: Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3. Metab Brain Dis. 31:827–835. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, Ballabh P, Wei JY, Wren JD, Ashpole NM, et al: Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: Implications for cerebromicrovascular and brain aging. Age (Dordr). 38:273–289. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Lee CH, Ahn JH, Park JH, Yan BC, Kim IH, Lee DH, Cho JH, Chen BH, Lee JC, Cho JH, et al: Decreased insulin-like growth factor-I and its receptor expression in the hippocampus and somatosensory cortex of the aged mouse. Neurochem Res. 39:770–776. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Bondy CA and Cheng CM: Insulin-like growth factor-1 promotes neuronal glucose utilization during brain development and repair processes. Int Rev Neurobiol. 51:189–217. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Cheng CM, Cohen M, Tseng V and Bondy CA: Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus. J Neurosci Res. 64:341–347. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Nieto-Estévez V, Defterali Ç and Vicario-Abejón C: IGF-I: A key growth factor that regulates neurogenesis and synaptogenesis from embryonic to adult stages of the brain. Front Neurosci. 10:522016. View Article : Google Scholar : PubMed/NCBI

15 

Liu W, Ye P, O'Kusky JR and D'Ercole AJ: Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus. J Neurosci Res. 87:2821–2832. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Carro E, Trejo JL, Gomez-Isla T, LeRoith D and Torres-Aleman I: Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat Med. 8:1390–1397. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Liu W, D'Ercole JA and Ye P: Blunting type 1 insulin-like growth factor receptor expression exacerbates neuronal apoptosis following hypoxic/ischemic injury. BMC Neurosci. 12:642011. View Article : Google Scholar : PubMed/NCBI

18 

LeRoith D, Werner H, Beitner-Johnson D and Roberts CT Jr: Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev. 16:143–163. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Czech MP: Signal transmission by the insulin-like growth factors. Cell. 59:235–238. 1989. View Article : Google Scholar : PubMed/NCBI

20 

Gazit N, Vertkin I, Shapira I, Helm M, Slomowitz E, Sheiba M, Mor Y, Rizzoli S and Slutsky I: IGF-1 receptor differentially regulates spontaneous and evoked transmission via mitochondria at hippocampal synapses. Neuron. 89:583–597. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Cheng CM, Reinhardt RR, Lee WH, Joncas G, Patel SC and Bondy CA: Insulin-like growth factor 1 regulates developing brain glucose metabolism. Proc Natl Acad Sci USA. 97:pp. 10236–10241. 2000; View Article : Google Scholar : PubMed/NCBI

22 

Madathil SK and Saatman KE: IGF-1/IGF-R Signaling in Traumatic Brain Injury: Impact on cell survival, neurogenesis and behavioral outcomeBrain Neurotrauma: Molecular, Neuropsychological and Rehabilitation Aspects. Kobeissy FH: CRC Press/Taylor & Francis; Boca Raton, FL: 2015

23 

Gualco E, Wang JY, Del Valle L, Urbanska K, Peruzzi F, Khalili K, Amini S and Reiss K: IGF-IR in neuroprotection and brain tumors. Front Biosci. 14:352–375. 2009. View Article : Google Scholar

24 

Song Y, Pimentel C, Walters K, Boller L, Ghiasvand S, Liu J, Staley KJ and Berdichevsky Y: Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury. Sci Rep. 6:320952016. View Article : Google Scholar : PubMed/NCBI

25 

Yang Y, Li X, Sun Q, He B, Jia Y, Cai D and Zhao R: Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway. Int J Biochem Cell Biol. 79:222–230. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Werner H and LeRoith D: Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects. Eur Neuropsychopharmacol. 24:1947–1953. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Sonntag WE, Lynch CD, Bennett SA, Khan AS, Thornton PL, Cooney PT, Ingram RL, McShane T and Brunso-Bechtold JK: Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. Neuroscience. 88:269–279. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Pentón-Rol G, Marin-Prida J, Pardo-Andreu G, Martínez-Sánchez G, Acosta-Medina EF, Valdivia-Acosta A, Lagumersindez-Denis N, Rodríguez-Jiménez E, Llópiz-Arzuaga A, López-Saura PA, et al: C-Phycocyanin is neuroprotective against global cerebral ischemia/reperfusion injury in gerbils. Brain Res Bull. 86:42–52. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Yan BC, Park JH, Ahn JH, Kim IH, Lee JC, Yoo KY, Choi JH, Hwang IK, Cho JH, Kwon YG, et al: Effects of high-fat diet on neuronal damage, gliosis, inflammatory process and oxidative stress in the hippocampus induced by transient cerebral ischemia. Neurochem Res. 39:2465–2478. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Yan BC, Ohk TG, Ahn JH, Park JH, Chen BH, Lee JC, Lee CH, Shin MC, Hwang IK, Moon SM, et al: Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia. J Neurol Sci. 337:129–136. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Shen H, Wang J, Jiang D, Xu P, Zhu X, Zhang Y, Yu X, Won MH, Su PQ and Yan BC: Topiramate improves neuroblast differentiation of hippocampal dentate gyrus in the D-galactose-induced aging mice via its antioxidant effects. Cell Mol Neurobiol. 37:869–877. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Kusumoto M, Arai H, Mori K and Sato K: Resistance to cerebral ischemia in developing gerbils. J Cereb Blood Flow Metab. 15:886–891. 1995. View Article : Google Scholar : PubMed/NCBI

33 

Yan BC, Park JH, Lee CH, Yoo KY, Choi JH, Lee YJ, Cho JH, Baek YY, Kim YM and Won MH: Increases of antioxidants are related to more delayed neuronal death in the hippocampal CA1 region of the young gerbil induced by transient cerebral ischemia. Brain Res. 1425:142–154. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Hernandez-Garzón E, Fernandez AM, Perez-Alvarez A, Genis L, Bascuñana P, Fernandez de la Rosa R, Delgado M, Angel Pozo M, Moreno E, McCormick PJ, et al: The insulin-like growth factor I receptor regulates glucose transport by astrocytes. Glia. 64:1962–1971. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Attwell D and Laughlin SB: An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab. 21:1133–1145. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Wu J, Lin B, Liu W, Huang J, Shang G, Lin Y, Wang L, Chen L and Tao J: Roles of electro-acupuncture in glucose metabolism as assessed by 18F-FDG/PET imaging and AMPKα phosphorylation in rats with ischemic stroke. Int J Mol Med. 40:875–882. 2017.PubMed/NCBI

37 

Simpson IA, Carruthers A and Vannucci SJ: Supply and demand in cerebral energy metabolism: The role of nutrient transporters. J Cereb Blood Flow Metab. 27:1766–1791. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Farrell CL and Pardridge WM: Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: An electron microscopic immunogold study. Proc Natl Acad Sci USA. 88:pp. 5779–5783. 1991; View Article : Google Scholar : PubMed/NCBI

39 

Duarte AI, Santos P, Oliveira CR, Santos MS and Rego AC: Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3beta signaling pathways and changes in protein expression. Biochim Biophys Acta. 1783:994–1002. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Hwang IK, Yoo KY, Park SK, An SJ, Lee JY, Choi SY, Kang JH, Kwon YG, Kang TC and Won MH: Expression and changes of endogenous insulin-like growth factor-1 in neurons and glia in the gerbil hippocampus and dentate gyrus after ischemic insult. Neurochem Int. 45:149–156. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Wadowska M, Woods J, Rogozinska M and Briones TL: Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin-like growth factor-1 signalling. Neuropathol Appl Neurobiol. 41:544–556. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Bergstedt K and Wieloch T: Changes in insulin-like growth factor 1 receptor density after transient cerebral ischemia in the rat. Lack of protection against ischemic brain damage following injection of insulin-like growth factor 1. J Cereb Blood Flow Metab. 13:895–898. 1993. View Article : Google Scholar : PubMed/NCBI

43 

Cui H, Meng Y and Bulleit RF: Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells. Brain Res Dev Brain Res. 111:177–188. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Johnston BM, Mallard EC, Williams CE and Gluckman PD: Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs. J Clin Invest. 97:300–308. 1996. View Article : Google Scholar : PubMed/NCBI

45 

Jiang LH, Yuan XL, Yang NY, Ren L, Zhao FM, Luo BX, Bian YY, Xu JY, Lu DX, Zheng YY, et al: Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway. J Steroid Biochem Mol Biol. 152:45–52. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Liang K, Ye Y, Wang Y, Zhang J and Li C: Formononetin mediates neuroprotection against cerebral ischemia/reperfusion in rats via downregulation of the Bax/Bcl-2 ratio and upregulation PI3K/Akt signaling pathway. J Neurol Sci. 344:100–104. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Wu D, Shi J, Elmadhoun O, Duan Y, An H, Zhang J, He X, Meng R, Liu X, Ji X and Ding Y: Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 1671:18–25. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Yang L, Zhang Y, Yan Z and Tian F: The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion. Exp Ther Med. 14:2839–2844. 2017.PubMed/NCBI

49 

Li X, Ren C, Li S, Han R, Gao J, Huang Q, Jin K, Luo Y and Ji X: Limb remote ischemic conditioning promotes myelination by upregulating PTEN/Akt/mTOR signaling activities after chronic cerebral hypoperfusion. Aging Dis. 8:392–401. 2017.PubMed/NCBI

50 

Zhuang Q, Dai C, Yang L, Wen H, Wang H, Jiang X and Zhang Y: Stimulated CB1 cannabinoid receptor inducing ischemic tolerance and protecting neuron from cerebral ischemia. Cent Nerv Syst Agents Med Chem. 17:141–150. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Gluckman P, Klempt N, Guan J, Mallard C, Sirimanne E, Dragunow M, Klempt M, Singh K, Williams C and Nikolics K: A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury. Biochem Biophys Res Commun. 182:593–599. 1992. View Article : Google Scholar : PubMed/NCBI

52 

Wang JM, Hayashi T, Zhang WR, Sakai K, Shiro Y and Abe K: Reduction of ischemic brain injury by topical application of insulin-like growth factor-I after transient middle cerebral artery occlusion in rats. Brain Res. 859:381–385. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yan BC, Wang J, Cao J and Won MH: Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region. Mol Med Rep 17: 3055-3061, 2018.
APA
Yan, B.C., Wang, J., Cao, J., & Won, M. (2018). Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region. Molecular Medicine Reports, 17, 3055-3061. https://doi.org/10.3892/mmr.2017.8243
MLA
Yan, B. C., Wang, J., Cao, J., Won, M."Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region". Molecular Medicine Reports 17.2 (2018): 3055-3061.
Chicago
Yan, B. C., Wang, J., Cao, J., Won, M."Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region". Molecular Medicine Reports 17, no. 2 (2018): 3055-3061. https://doi.org/10.3892/mmr.2017.8243
Copy and paste a formatted citation
x
Spandidos Publications style
Yan BC, Wang J, Cao J and Won MH: Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region. Mol Med Rep 17: 3055-3061, 2018.
APA
Yan, B.C., Wang, J., Cao, J., & Won, M. (2018). Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region. Molecular Medicine Reports, 17, 3055-3061. https://doi.org/10.3892/mmr.2017.8243
MLA
Yan, B. C., Wang, J., Cao, J., Won, M."Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region". Molecular Medicine Reports 17.2 (2018): 3055-3061.
Chicago
Yan, B. C., Wang, J., Cao, J., Won, M."Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region". Molecular Medicine Reports 17, no. 2 (2018): 3055-3061. https://doi.org/10.3892/mmr.2017.8243
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team