Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database

  • Authors:
    • Xinxing Lu
    • Lu Xue
    • Wenbin Sun
    • Jilu Ye
    • Zhiyun Zhu
    • Haifeng Mei
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Medicine, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3042-3054
    |
    Published online on: December 12, 2017
       https://doi.org/10.3892/mmr.2017.8258
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sepsis is a life-threatening condition in which an uncontrolled inflammatory host response is triggered. The exact pathogenesis of sepsis remains unclear. The aim of the present study was to identify key genes that may aid in the diagnosis and treatment of sepsis. mRNA expression data from blood samples taken from patients with sepsis and healthy individuals was downloaded from the Gene Expression Omnibus database and differentially expressed genes (DEGs) between the two groups were identified. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and protein‑protein interaction (PPI) network construction, was performed to investigate the function of the identified DEGs. Furthermore, for validation of these results, the expression levels of several DEGs were analyzed by reverse transcription quantitative‑polymerase chain reaction (RT‑qPCR) in three patients with sepsis and three healthy blood samples to support the results obtained from the bioinformatics analysis. Receiver operating characteristic analyses were also used to analyze the diagnostic ability of the identified DEGs for sepsis. The results demonstrated that a total of 4,402 DEGs, including 1,960 upregulated and 2,442 downregulated genes, were identified between patients with sepsis and healthy individuals. KEGG pathway analysis revealed that 39 DEGs were significantly enriched in toll‑like receptor signaling pathways. The top 20 upregulated and downregulated DEGs were used to construct the PPI network. Hub genes with high degrees, including interleukin 1 receptor‑associated kinase 3 (IRAK3), S100 calcium‑binding protein (S100)A8, angiotensin II receptor‑associated protein (AGTRAP) and S100A9, were demonstrated to be associated sepsis. Furthermore, RT‑qPCR results demonstrated that IRAK3, adrenomedullin (ADM), arachidonate 5‑lipoxygenase (ALOX5), matrix metallopeptidase 9 (MMP9) and S100A8 were significantly upregulated, while ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) was upregulated but not significantly, in blood samples from patients with sepsis compared with healthy individuals, which was consistent with bioinformatics analysis results. Therefore, AGTRAP, IRAK3, ADM, ALOX5, MMP9, S100A8 and ENTPD1 were identified to have potential diagnostic value in sepsis. In conclusion, dysregulated levels of the AGTRAP, IRAK3, ADM, ALOX5, MMP9, S100A8 and ENTPD1 genes may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers or therapeutic targets.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Bao R, Shui X, Hou J, Li J, Deng X, Zhu X and Yang T: Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 38:969–975. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Jawad I, Lukšić I and Rafnsson SB: Assessing available information on the burden of sepsis: Global estimates of incidence, prevalence and mortality. J Glob Health. 2:0104042012. View Article : Google Scholar : PubMed/NCBI

3 

Martin GS, Mannino DM and Moss M: The effect of age on the development and outcome of adult sepsis. Criti Care Med. 34:15–21. 2006. View Article : Google Scholar

4 

Strehlow MC, Emond SD, Shapiro NI, Pelletier AJ and Camargo CA Jr: National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med. 48:326–331, 331.e1-e3. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Martin GS, Mannino DM, Eaton S and Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 348:1546–1554. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Murphy SL: Deaths: Final data for 1998. Natl Vital Stat Rep. 48:1–105. 2000.PubMed/NCBI

7 

Hotchkiss RS and Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med. 348:138–150. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, et al: A network-based analysis of systemic inflammation in humans. Nature. 437:1032–1037. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Wurfel MM, Gordon AC, Holden TD, Radella F, Strout J, Kajikawa O, Ruzinski JT, Rona G, Black RA, Stratton S, et al: Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med. 178:710–720. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J and Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med. 29:1303–1310. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Pankla R, Buddhisa S, Berry M, Blankenship DM, Bancroft GJ, Banchereau J, Lertmemongkolchai G and Chaussabel D: Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis. Genome Biol. 10:R1272009. View Article : Google Scholar : PubMed/NCBI

12 

Wu JQ, Sassé TR, Wolkenstein G, Conceicao V, Saksena MM, Soedjono M, Perera SS, Wang B, Dwyer DE and Saksena NK: Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors. Virology. 435:308–319. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Marot G, Foulley JL, Mayer CD and Jaffrézic F: Moderated effect size and P-value combinations for microarray meta-analyses. Bioinformatics. 25:2692–2699. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Reiner-Benaim A: FDR control by the BH procedure for two-sided correlated tests with implications to gene expression data analysis. Biom J. 49:107–126. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Benjamini Y and Hochberg Y: Controlling the false discovery rate-a practical and powerful approach to multiple testing. J Royal Stat Soc. 57:289–300. 1995.

16 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Pino-Yanes M, Ma SF, Sun X, Tejera P, Corrales A, Blanco J, Pérez-Méndez L, Espinosa E, Muriel A, Blanch L, et al: Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injury. Am J Respir Cell Mol Biol. 45:740–745. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Kesik V, Ataş E, Gülcan Kurt Y, Aydın FN, Babacan O, Gülgün M and Korkmazer N: Adrenomedullin predicts high risk and culture positivity in children with solid tumors suffering from neutropenic fever. J Infect Chemother. 22:617–621. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Pavanelli WR, Gutierrez FR, Mariano FS, Prado CM, Ferreira BR, Teixeira MM, Canetti C, Rossi MA, Cunha FQ and Silva JS: 5-lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection. Microbes Infect. 12:587–597. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Shogan BD, Belogortseva N, Luong PM, Zaborin A, Lax S, Bethel C, Ward M, Muldoon JP, Singer M, An G, et al: Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Sci Transl Med. 7:286ra2682015. View Article : Google Scholar

21 

Zhang LN, Wang XH, Wu L, Huang L, Zhao CG, Peng QY and Ai YH: Diagnostic and predictive levels of calcium-binding protein A8 and tumor necrosis factor receptor-associated factor 6 in sepsis-associated encephalopathy: A prospective observational study. Chin Med J (Engl). 129:1674–1681. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Hall MW, Gavrilin MA, Knatz NL, Duncan MD, Fernandez SA and Wewers MD: Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome. Pediatr Res. 62:597–603. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Escoll P, del Fresno C, García L, Vallés G, Lendínez MJ, Arnalich F and López-Collazo E: Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients. Biochem Biophys Res Commun. 311:465–472. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Cazalis MA, Lepape A, Venet F, Frager F, Mougin B, Vallin H, Paye M, Pachot A and Monneret G: Early and dynamic changes in gene expression in septic shock patients: A genome-wide approach. Intensive Care Med Exp. 2:202014. View Article : Google Scholar : PubMed/NCBI

25 

Deng JC, Cheng G, Newstead MW, Zeng X, Kobayashi K, Flavell RA and Standiford TJ: Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. The J Clin Invest. 116:2532–2542. 2006.PubMed/NCBI

26 

Ueda S, Nishio K, Minamino N, Kubo A, Akai Y, Kangawa K, Matsuo H, Fujimura Y, Yoshioka A, Masui K, et al: Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome. Am J Respir Crit Care Med. 160:132–136. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Hirata Y, Mitaka C, Sato K, Nagura T, Tsunoda Y, Amaha K and Marumo F: Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metabol. 81:1449–1453. 1996. View Article : Google Scholar

28 

Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T and Matsuo H: Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells. Biochem Biophys Res Commun. 207:25–32. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Musson DS, McLachlan JL, Sloan AJ, Smith AJ and Cooper PR: Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization. Biol Cell. 102:145–157. 2010. View Article : Google Scholar : PubMed/NCBI

30 

So S, Hattori Y, Kasai K, Shimoda S and Gross SS: Up-regulation of rat adrenomedullin gene expression by endotoxin: Relation to nitric oxide synthesis. Life sciences. 58:Pl309–P1315. 1996. View Article : Google Scholar : PubMed/NCBI

31 

Simon TP, Martin L, Doemming S, Humbs A, Bruells C, Kopp R, Hartmann O, Struck J, Bergmann A, Marx G and Schuerholz T: Plasma adrenomedullin in critically ill patients with sepsis after major surgery: A pilot study. J Crit Care. 38:68–72. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Talwar S, Munson PJ, Barb J, Fiuza C, Cintron AP, Logun C, Tropea M, Khan S, Reda D, Shelhamer JH, et al: Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans. Physiol Genomics. 25:203–215. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Prabhakar U, Conway TM, Murdock P, Mooney JL, Clark S, Hedge P, Bond BC, Jazwinska EC, Barnes MR, Tobin F, et al: Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects. DNA Cell Biol. 24:410–431. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Peters-Golden M and Henderson WR Jr: Leukotrienes. N Engl J Med. 357:1841–1854. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Monteiro AP, Soledade E, Pinheiro CS, Dellatorre-Teixeira L, Oliveira GP, Oliveira MG, Peters-Golden M, Rocco PR, Benjamim CF and Canetti C: Pivotal role of the 5-lipoxygenase pathway in lung injury after experimental sepsis. Am J Respir Cell Mol Biol. 50:87–95. 2014.PubMed/NCBI

36 

Collin M, Rossi A, Cuzzocrea S, Patel NS, Di Paola R, Hadley J, Collino M, Sautebin L and Thiemermann C: Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. J Leukoc Biol. 76:961–970. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Das UN: Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS. Lipids Health Dis. 15:2062016. View Article : Google Scholar : PubMed/NCBI

38 

Stamenkovic I: Extracellular matrix remodelling: The role of matrix metalloproteinases. J Pathol. 200:448–464. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Chakrabarti S and Patel KD: Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils. J Leukoc Biol. 78:279–288. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Sheu JR, Fong TH, Liu CM, Shen MY, Chen TL, Chang Y, Lu MS and Hsiao G: Expression of matrix metalloproteinase-9 in human platelets: Regulation of platelet activation in in vitro and in vivo studies. Br J Pharmacol. 143:193–201. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Lee YM, Lee JJ, Shen MY, Hsiao G and Sheu JR: Inhibitory mechanisms of activated matrix metalloproteinase-9 on platelet activation. Eur J Pharmacol. 537:52–58. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Jin LY, Li CF, Zhu GF, Wu CT, Wang J and Yan SF: Effect of siRNA against NF-κB on sepsisinduced acute lung injury in a mouse model. Mol Med Rep. 10:631–637. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Cizmeci MN, Kara S, Kanburoglu MK, Simavli S, Duvan CI and Tatli MM: Detection of cord blood hepcidin levels as a biomarker for early-onset neonatal sepsis. Med Hypotheses. 82:310–312. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Hoffmann U, Bertsch T, Dvortsak E, Liebetrau C, Lang S, Liebe V, Huhle G, Borggrefe M and Brueckmann M: Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: Prognostic value of TIMP-1 in severe sepsis. Scand J Infect Dis. 38:867–872. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Edgar JD, Gabriel V, Gallimore JR, McMillan SA and Grant J: A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection. BMC Pediatr. 10:222010. View Article : Google Scholar : PubMed/NCBI

46 

Gebhardt C, Nemeth J, Angel P and Hess J: S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 72:1622–1631. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Buhimschi IA and Buhimschi CS: The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis. Clin Perinatol. 37:355–374. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Buhimschi CS, Buhimschi IA, Abdel-Razeq S, Rosenberg VA, Thung SF, Zhao G, Wang E and Bhandari V: Proteomic biomarkers of intra-amniotic inflammation: Relationship with funisitis and early-onset sepsis in the premature neonate. Pediatr Res. 61:318–324. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Buhimschi CS, Bhandari V, Dulay AT, Nayeri UA, Abdel-Razeq SS, Pettker CM, Thung S, Zhao G, Han YW, Bizzarro M and Buhimschi IA: Proteomics mapping of cord blood identifies haptoglobin ‘switch-on’ pattern as biomarker of early-onset neonatal sepsis in preterm newborns. PLoS One. 6:e261112011. View Article : Google Scholar : PubMed/NCBI

50 

Csóka B, Németh ZH, Törő G, Koscsó B, Kókai E, Robson SC, Enjyoji K, Rolandelli RH, Erdélyi K, Pacher P and Haskó G: CD39 improves survival in microbial sepsis by attenuating systemic inflammation. FASEB J. 29:25–36. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Haskó G, Csóka B, Koscsó B, Chandra R, Pacher P, Thompson LF, Deitch EA, Spolarics Z, Virág L, Gergely P, et al: Ecto-5′-nucleotidase (CD73) decreases mortality and organ injury in sepsis. J Immunol. 187:4256–4267. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Eltzschig HK, Thompson LF, Karhausen J, Cotta RJ, Ibla JC, Robson SC and Colgan SP: Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: Coordination by extracellular nucleotide metabolism. Blood. 104:3986–3992. 2004. View Article : Google Scholar : PubMed/NCBI

53 

Köhler D, Eckle T, Faigle M, Grenz A, Mittelbronn M, Laucher S, Hart ML, Robson SC, Müller CE and Eltzschig HK: CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury. Circulation. 116:1784–1794. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Grenz A, Zhang H, Hermes M, Eckle T, Klingel K, Huang DY, Müller CE, Robson SC, Osswald H and Eltzschig HK: Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 21:2863–2873. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Hart ML, Gorzolla IC, Schittenhelm J, Robson SC and Eltzschig HK: SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning. J Immunol. 184:4017–4024. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Riedemann NC, Guo RF and Ward PA: The enigma of sepsis. J Clin Invest. 112:460–467. 2003. View Article : Google Scholar : PubMed/NCBI

57 

Nakada TA, Russell JA, Boyd JH, McLaughlin L, Nakada E, Thair SA, Hirasawa H, Oda S and Walley KR: Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock. Crit Care Med. 39:1641–1648. 2011. View Article : Google Scholar : PubMed/NCBI

58 

Mares CA, Ojeda SS, Morris EG, Li Q and Teale JM: Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns. Infect Immun. 76:3001–3010. 2008. View Article : Google Scholar : PubMed/NCBI

59 

Fontaine M, Pachot A, Larue A, Mougin B, Landelle C, Venet F, Allombert C, Cazalis MA, Monneret G and Lepape A: Delayed increase of S100A9 messenger RNA predicts hospital-acquired infection after septic shock. Crit Care Med. 39:2684–2690. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Feuerstein GZ: Cardiac RAGE in sepsis: Call TOLL free for anti-RAGE. Circ Res. 102:1153–1154. 2008. View Article : Google Scholar : PubMed/NCBI

61 

van Zoelen MA, Vogl T, Foell D, Van Veen SQ, van Till JW, Florquin S, Tanck MW, Wittebole X, Laterre PF, Boermeester MA, et al: Expression and role of myeloid-related protein-14 in clinical and experimental sepsis. Am J Respir Crit Care Med. 180:1098–1106. 2009. View Article : Google Scholar : PubMed/NCBI

62 

West AP, Koblansky AA and Ghosh S: Recognition and signaling by toll-like receptors. Ann Rev Cell Dev Biol. 22:409–437. 2006. View Article : Google Scholar

63 

Buchholz BM and Bauer AJ: Membrane TLR signaling mechanisms in the gastrointestinal tract during sepsis. Neurogastroenterol Motil. 22:232–245. 2010. View Article : Google Scholar : PubMed/NCBI

64 

Savva A and Roger T: Targeting toll-like receptors: Promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases. Front Immunol. 4:3872013. View Article : Google Scholar : PubMed/NCBI

65 

Mansur A, von Gruben L, Popov AF, Steinau M, Bergmann I, Ross D, Ghadimi M, Beissbarth T, Bauer M and Hinz J: The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients. J Transl Med. 12:1772014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lu X, Xue L, Sun W, Ye J, Zhu Z and Mei H: Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database. Mol Med Rep 17: 3042-3054, 2018.
APA
Lu, X., Xue, L., Sun, W., Ye, J., Zhu, Z., & Mei, H. (2018). Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database. Molecular Medicine Reports, 17, 3042-3054. https://doi.org/10.3892/mmr.2017.8258
MLA
Lu, X., Xue, L., Sun, W., Ye, J., Zhu, Z., Mei, H."Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database". Molecular Medicine Reports 17.2 (2018): 3042-3054.
Chicago
Lu, X., Xue, L., Sun, W., Ye, J., Zhu, Z., Mei, H."Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database". Molecular Medicine Reports 17, no. 2 (2018): 3042-3054. https://doi.org/10.3892/mmr.2017.8258
Copy and paste a formatted citation
x
Spandidos Publications style
Lu X, Xue L, Sun W, Ye J, Zhu Z and Mei H: Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database. Mol Med Rep 17: 3042-3054, 2018.
APA
Lu, X., Xue, L., Sun, W., Ye, J., Zhu, Z., & Mei, H. (2018). Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database. Molecular Medicine Reports, 17, 3042-3054. https://doi.org/10.3892/mmr.2017.8258
MLA
Lu, X., Xue, L., Sun, W., Ye, J., Zhu, Z., Mei, H."Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database". Molecular Medicine Reports 17.2 (2018): 3042-3054.
Chicago
Lu, X., Xue, L., Sun, W., Ye, J., Zhu, Z., Mei, H."Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database". Molecular Medicine Reports 17, no. 2 (2018): 3042-3054. https://doi.org/10.3892/mmr.2017.8258
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team