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Article Open Access

Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction

  • Authors:
    • Jie Zhang
    • Peng‑Peng Jin
    • Min Gong
    • Qing‑Tong Yi
    • Ru‑Jian Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, P.R. China, Center for Medical Research, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7065-7072
    |
    Published online on: March 15, 2018
       https://doi.org/10.3892/mmr.2018.8753
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Abstract

The present study investigated the expression of leptin and its receptor in the left testis and hypothalamus of rats with varicocele and clarified their roles in the pathogenesis of varicocele‑induced testicular dysfunction. A total of 40 male rats were divided randomly into four groups. Groups 1 (G1) and 3 (G3) underwent a sham operation. Groups 2 (G2) and 4 (G4) underwent operations to form a varicocele created by partial ligation of the left renal vein. G1 and G2 rats were euthanized 4 weeks after the operation while G3 and G4 rats were euthanized at 8 weeks. The expression of leptin and its receptor was analyzed by immunohistochemistry. The mRNA levels of leptin, its receptor, kisspeptin (KiSS‑1), G‑protein coupled receptor 54 (GPR54), gonadotropin releasing hormone (GnRH), luteinizing hormone (LH), and follicle‑stimulating hormone (FSH) were measured by reverse transcription‑quantitative polymerase chain reaction. Testicular spermatogenesis function and gonadal hormone levels were measured. Compared with G1 and G3, the expression of leptin and its receptor in rat testis was significantly higher in G2 and G4, respectively. Leptin expression was inversely associated with the number of sperm in the left epididymis, thickness of the seminiferous epithelium and the diameter of seminiferous tubules. The expression of leptin receptors in the hypothalamus of G2 and G4 was significantly increased compared with that in G1 and G3, respectively. The mRNA levels of KiSS‑1, GPR54, GnRH, LH and FSH in G2 and G4 were significantly increased compared with that in G1 and G3, respectively. Serum testosterone levels in G2 and G4 rats were significantly lower than those in G1 and G3 rats, respectively. There was no significant difference between the serum levels of FSH, LH and leptin. These results suggest that leptin and its receptor may serve significant roles in the pathogenesis of varicocele-induced testicular dysfunction.
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1 

Lai YW, Hsueh TY, Hu HY, Chiu YC, Chen SS and Chiu AW: Varicocele is associated with varicose veins: A population-based case-control study. Int J Urol. 22:972–975. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Shiraishi K, Matsuyama H and Takihara H: Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. Int J Urol. 19:538–550. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Sáinz N, Barrenetxe J, Moreno-Aliaga MJ and Martínez JA: Leptin resistance and diet-induced obesity: Central and peripheral actions of leptin. Metabolism. 64:35–46. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Schulz LC and Widmaier EP: Leptin receptors. Endocrine Updates. 83:271–361. 2006.

5 

Barash IA, Cheung CC, Weigle DS, Ren H, Kabigting EB, Kuijper JL, Clifton DK and Steiner RA: Leptin is a metabolic signal to the reproductive system. Endocrinology. 137:3144–3147. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Budak E, Fernández Sánchez M, Bellver J, Cerveró A, Simón C and Pellicer A: Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil Steril. 85:1563–1581. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Kawwass JF, Summer R and Kallen CB: Direct effects of leptin and adiponectin on peripheral reproductive tissues: A critical review. Mol Hum Reprod. 21:617–632. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Fombonne J, Charrier C, Goddard I, Moyse E and Krantic S: Leptin-mediated decrease of cyclin A2 and increase of cyclin D1 expression: Relevance for the control of prepubertal rat Leydig cell division and differentiation. Endocrinology. 148:2126–2137. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Grosfeld A, Andre J, Hauguel-De Mouzon S, Berra E, Pouyssegur J and Guerre-Millo M: Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem. 277:42953–42957. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Ishikawa T, Fujioka H, Ishimura T, Takenaka A and Fujisawa M: Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia. 39:22–27. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Turner TT: The study of varicocele through the use of animal models. Hum Reprod Update. 7:78–84. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Johnsen SG: Testicular biopsy score count-a method for registration of spermatogenesis in human testes: Normal values and results in 335 hypogonadal males. Hormone. 1:2–25. 1970.

13 

Agarwal A, Sharma R, Harlev A and Esteves SC: Effect of varicocele on semen characteristics according to the new 2010 World Health Organization criteria: A systematic review and meta-analysis. Asian J Androl. 18:163–170. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Smith MS, True C and Grove KL: The neuroendocrine basis of lactation-induced suppression of GnRH: Role of kisspeptin and leptin. Brain Res. 1364:139–152. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Chen B, Guo JH, Lu YN, Ying XL, Hu K, Xiang ZQ, Wang YX, Chen P and Huang YR: Leptin and varicocele-related spermatogenesis dysfunction: Animal experiment and clinical study. Int J Androl. 32:532–541. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Donato J Jr, Cravo RM, Frazão R and Elias CF: Hypothalamic sites of leptin action linking metabolism and reproduction. Neuroendocrinology. 93:9–18. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Lebrethon MC, Vandersmissen E, Gérard A, Parent AS, Junien JL and Bourguignon JP: In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms. Endocrinology. 141:1464–1469. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Tena-Sempere M, Pinilla L, González LC, Diéguez C, Casanueva FF and Aguilar E: Leptin inhibits testosterone secretion from adult rat testis in vitro. J Endocrinol. 161:211–218. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Tena-Sempere M, Manna PR, Zhang FP, Pinilla L, González LC, Diéguez C, Huhtaniemi I and Aguilar E: Molecular mechanisms of leptin action in adult rat testis: Potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin receptor messenger ribonucleic acid expression. J Endocrinol. 170:413–423. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Glander HJ, Lammert A, Paasch U, Glasow A and Kratzsch J: Leptin exists in tubuli seminiferi and in seminal plasma. Andrologia. 34:227–233. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Dungan HM, Clifton DK and Steiner RA: Minireview: Kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology. 147:1154–1158. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Skorupskaite K, George JT and Anderson RA: The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 20:485–500. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Morelli A, Marini M, Mancina R, Luconi M, Vignozzi L, Fibbi B, Filippi S, Pezzatini A, Forti G, Vannelli GB and Maggi M: Sex steroids and leptin regulate the ‘first Kiss’ (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts. J Sex Med. 5:1097–1113. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Popa SM, Clifton DK and Steiner RA: The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction. Annu Rev Physiol. 70:213–238. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Jin PP, Gong M, Yi QT and Zhu RJ: Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction. Mol Med Rep 17: 7065-7072, 2018.
APA
Zhang, J., Jin, P., Gong, M., Yi, Q., & Zhu, R. (2018). Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction. Molecular Medicine Reports, 17, 7065-7072. https://doi.org/10.3892/mmr.2018.8753
MLA
Zhang, J., Jin, P., Gong, M., Yi, Q., Zhu, R."Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction". Molecular Medicine Reports 17.5 (2018): 7065-7072.
Chicago
Zhang, J., Jin, P., Gong, M., Yi, Q., Zhu, R."Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction". Molecular Medicine Reports 17, no. 5 (2018): 7065-7072. https://doi.org/10.3892/mmr.2018.8753
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Jin PP, Gong M, Yi QT and Zhu RJ: Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction. Mol Med Rep 17: 7065-7072, 2018.
APA
Zhang, J., Jin, P., Gong, M., Yi, Q., & Zhu, R. (2018). Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction. Molecular Medicine Reports, 17, 7065-7072. https://doi.org/10.3892/mmr.2018.8753
MLA
Zhang, J., Jin, P., Gong, M., Yi, Q., Zhu, R."Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction". Molecular Medicine Reports 17.5 (2018): 7065-7072.
Chicago
Zhang, J., Jin, P., Gong, M., Yi, Q., Zhu, R."Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction". Molecular Medicine Reports 17, no. 5 (2018): 7065-7072. https://doi.org/10.3892/mmr.2018.8753
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