Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2018 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression

  • Authors:
    • Dawei Wang
    • Xiaoqian Lou
    • Xiao‑Ming Jiang
    • Chenxi Yang
    • Xiao‑Liang Liu
    • Nan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Endocrinology, Second Department, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Centre for Heart and Lung Innovation, University of British Columbia, Vancouver, BC V6P 2G9, Canada
  • Pages: 610-616
    |
    Published online on: May 8, 2018
       https://doi.org/10.3892/mmr.2018.8994
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

With extensive pharmacological actions, quercetin has anti‑oxidant, free radical scavenging, anti‑tumor, anti‑inflammatory, anti‑bacterial and anti‑viral activity. Quercetin also reduces blood glucose and reduces high blood pressure, and has immunoregulation and cardiovascular protection functions. Additionally, it has been reported that it can reduce depression. The current study evaluated whether quercetin protects against inflammation, matrix metalloproteinase‑2 (MMP‑2) activation and apoptosis induction in a rat model of cardiopulmonary resuscitation (CPR), and whether Bmi‑1 expression was involved in the effects. In CPR model rats, treatment with quercetin significantly recovered left ventricular ejection fraction, left ventricular fractional shortening, ejection fraction (%), and left ventricle weight/body weight. Treatment with quercetin significantly inhibited ROS generation, inflammation and MMP‑2 protein expression in the rat model CPR. Finally, quercetin significantly suppressed caspase‑3 activity and activated Bmi‑1 protein expression in the rat model of CPR. The results demonstrated that quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in a rat model of CPR, and that this may be mediated by modulating Bmi‑1 expression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Capuano F, Lechiancole A, Angeloni E, Goracci M, Bianchin R, Roscitano A, Comito C, Melina G and Sinatra R: Miniaturized versus conventional cardiopulmonary bypass in patients undergoing coronary artery bypass surgery: Impact on lymphocyte depletion and sternal wound healing. J Cardiothorac Surg. 10 Suppl 1:A3222015. View Article : Google Scholar :

2 

Wang XT, Liu DW, Zhang HM and Chai WZ: Integrated cardiopulmonary sonography: A useful tool for assessment of acute pulmonary edema in the intensive care unit. J Ultrasound Med. 33:1231–1239. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Souza SS, Intelisano TR, De Biaggi CP, Moura CA, Selmi AL, Dias RA and Cortopassi SR: Cardiopulmonary and isoflurane-sparing effects of epidural or intravenous infusion of dexmedetomidine in cats undergoing surgery with epidural lidocaine. Vet Anaesth Analg. 37:106–115. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Wang X, Ji B, Zhang Y, Zhu X, Liu J, Long C and Zheng Z: Comparison of the effects of three cell saver devices on erythrocyte function during cardiopulmonary bypass procedure-a pilot study. Artif Organs. 36:931–935. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Bhutta AT, Schmitz ML, Swearingen C, James LP, Wardbegnoche WL, Lindquist DM, Glasier CM, Tuzcu V, Prodhan P, Dyamenahalli U, et al: Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: A pilot randomized, double-blind, placebo-controlled trial. Pediatr Crit Care Med. 13:328–337. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sun YJ, Song DD, Diao YG, Zhou J and Zhang TZ: Penehyclidine hydrochloride preserves the intestinal barrier function in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg. 146:179–185. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Garner JR, Stroud RE, Finklea L, Ikonomidis JS, Dorman BH and Spinale FG: The effects of leukocyte reduction on matrix metalloproteinase release in cardiopulmonary bypass. J Extra Corpor Technol. 36:185–190. 2004.PubMed/NCBI

8 

Smith CR, Stamou SC, Boeve TJ and Hooker RC: Repair of a penetrating ascending aortic ulcer with localized resection and extracellular matrix patch aortoplasty. Ann Thorac Surg. 94:988–989. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Asberg AE and Videm V: Neutrophil dysfunction after biomaterial contact in an in vitro model of cardiopulmonary bypass. Eur J Cardiothorac Surg. 30:744–748. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Chowdhury B, Hemming R, Hombach-Klonisch S, Flamion B and Triggs-Raine B: Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction. J Biol Chem. 288:520–528. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Wang MC, Li CL, Cui J, Jiao M, Wu T, Jing LI and Nan KJ: BMI-1, a promising therapeutic target for human cancer. Oncol Lett. 10:583–588. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Jiang L, Li J and Song L: Bmi-1, stem cells and cancer. Acta Biochim Biophys Sin (Shanghai). 41:527–534. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Koning NJ, de Lange F, Vonk AB, Ahmed Y, van den Brom CE, Bogaards S, van Meurs M, Jongman RM, Schalkwijk CG, Begieneman MP, et al: Impaired microcirculatory perfusion in a rat model of cardiopulmonary bypass: The role of hemodilution. Am J Physiol Heart Circ Physiol. 310:H550–H558. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Link MS, Myerburg RJ and Estes NA III: American Heart Association Electrocardiography and Arrhythmias Committee of Council on Clinical Cardiology, Council on Cardiovascular Disease in Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology, and American College of Cardiology: Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task force 12: Emergency action plans, resuscitation, cardiopulmonary resuscitation, and automated external defibrillators: A scientific statement from the American heart association and American college of cardiology. Circulation. 132:e334–e338. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Zhang Y, Huang C, Liu S, Bai J, Fan X, Guo J, Jia Y, Zhang Z, Chen X, Jia Y, et al: Effects of quercetin on intracavernous pressure and expression of nitrogen synthase isoforms in arterial erectile dysfunction rat model. Int J Clin Exp Med. 8:7599–7605. 2015.PubMed/NCBI

16 

Barteková M, Šimončíková P, Fogarassyová M, Ivanová M, Okruhlicová L', Tribulová N, Dovinová I and Barančík M: Quercetin improves postischemic recovery of heart function in doxorubicin-treated rats and prevents doxorubicin-induced matrix metalloproteinase-2 activation and apoptosis induction. Int J Mol Sci. 16:8168–8185. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Shen XC, Yang YP, Xiao TT, Peng J and Liu XD: Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-β1-smads signal pathway. J Asian Nat Prod Res. 13:215–224. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Uraoka M, Nakajima Y, Kurita T, Suzuki A, Takata K and Sato S: Landiolol, an ultra short acting beta1-blocker, improves pulmonary edema after cardiopulmonary resuscitation with epinephrine in rats. J Anesth. 24:67–72. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Ye S, Weng Y, Sun S, Chen W, Wu X, Li Z, Weil MH and Tang W: Comparison of the durations of mild therapeutic hypothermia on outcome after cardiopulmonary resuscitation in the rat. Circulation. 125:123–129. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Duppen N, Etnel JR, Spaans L, Takken T, van den Berg-Emons RJ, Boersma E, Schokking M, Dulfer K, Utens EM, Helbing W and Hopman MT: Does exercise training improve cardiopulmonary fitness and daily physical activity in children and young adults with corrected tetralogy of Fallot or Fontan circulation? A randomized controlled trial. Am Heart J. 170:606–614. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Durukan AB, Gurbuz HA, Salman N, Unal EU, Ucar HI and Yorgancioglu CE: Ventilation during cardiopulmonary bypass did not attenuate inflammatory response or affect postoperative outcomes. Cardiovasc J Afr. 24:224–230. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Guizilini S, Alves DF, Bolzan DW, Cancio AS, Regenga MM, Moreira RS, Trimer R and Gomes WJ: Sub-xyphoid pleural drain as a determinant of functional capacity and clinical results after off-pump coronary artery bypass surgery: A randomized clinical trial. Interact Cardiovasc Thorac Surg. 19:382–387. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Sayed S, Idriss NK, Sayyedf HG, Ashry AA, Rafatt DM, Mohamed AO and Blann AD: Effects of propofol and isoflurane on haemodynamics and the inflammatory response in cardiopulmonary bypass surgery. Br J Biomed Sci. 72:93–101. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Liu K, Mei F, Wang Y, Xiao N, Yang L, Wang Y, Li J, Huang F, Kou J, Liu B and Qi LW: Quercetin oppositely regulates insulin-mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation. Mol Nutr Food Res. 60:551–565. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Wang CT, Zhang L, Wu HW, Wei L, Xu B and Li DM: Doxycycline attenuates acute lung injury following cardiopulmonary bypass: Involvement of matrix metalloproteinases. Int J Clin Exp Pathol. 7:7460–7468. 2014.PubMed/NCBI

26 

He ZJ, Huang ZT, Chen XT and Zou ZJ: Effects of matrix metalloproteinase 9 inhibition on the blood brain barrier and inflammation in rats following cardiopulmonary resuscitation. Chin Med J (Engl). 122:2346–2351. 2009.PubMed/NCBI

27 

Liu K, Shen L, Wang J, Dong G, Wu H, Shao H and Jing H: The preventative role of curcumin on the lung inflammatory response induced by cardiopulmonary bypass in rats. J Surg Res. 174:73–82. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD and Ichinose F: Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice. Circulation. 120:888–896. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Mendoza-Paredes A, Liu H, Schears G, Yu Z, Markowitz SD, Schultz S, Pastuszko P, Greeley WJ, Nadkarni V, Kubin J, et al: Resuscitation with 100%, compared with 21%, oxygen following brief, repeated periods of apnea can protect vulnerable neonatal brain regions from apoptotic injury. Resuscitation. 76:261–270. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Shuja F, Tabbara M, Li Y, Liu B, Butt MU, Velmahos GC, DeMoya M and Alam HB: Profound hypothermia decreases cardiac apoptosis through Akt survival pathway. J Am Coll Surg. 209:89–99. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Wiedemann D, Schachner T, Bonaros N, Weidinger F, Kolbitsch C, Friedrich G, Laufer G and Bonatti J: Does obesity affect operative times and perioperative outcome of patients undergoing totally endoscopic coronary artery bypass surgery? Interact Cardiovasc Thorac Surg. 9:214–217. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Dong Q, Chen L, Lu Q, Sharma S, Li L, Morimoto S and Wang G: Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression. Br J Pharmacol. 171:4440–4454. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang D, Lou X, Jiang XM, Yang C, Liu XL and Zhang N: Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. Mol Med Rep 18: 610-616, 2018.
APA
Wang, D., Lou, X., Jiang, X., Yang, C., Liu, X., & Zhang, N. (2018). Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. Molecular Medicine Reports, 18, 610-616. https://doi.org/10.3892/mmr.2018.8994
MLA
Wang, D., Lou, X., Jiang, X., Yang, C., Liu, X., Zhang, N."Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression". Molecular Medicine Reports 18.1 (2018): 610-616.
Chicago
Wang, D., Lou, X., Jiang, X., Yang, C., Liu, X., Zhang, N."Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression". Molecular Medicine Reports 18, no. 1 (2018): 610-616. https://doi.org/10.3892/mmr.2018.8994
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Lou X, Jiang XM, Yang C, Liu XL and Zhang N: Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. Mol Med Rep 18: 610-616, 2018.
APA
Wang, D., Lou, X., Jiang, X., Yang, C., Liu, X., & Zhang, N. (2018). Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. Molecular Medicine Reports, 18, 610-616. https://doi.org/10.3892/mmr.2018.8994
MLA
Wang, D., Lou, X., Jiang, X., Yang, C., Liu, X., Zhang, N."Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression". Molecular Medicine Reports 18.1 (2018): 610-616.
Chicago
Wang, D., Lou, X., Jiang, X., Yang, C., Liu, X., Zhang, N."Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression". Molecular Medicine Reports 18, no. 1 (2018): 610-616. https://doi.org/10.3892/mmr.2018.8994
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team