Open Access

Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium

  • Authors:
    • Nan Guo
    • Nan Zhang
    • Liqiu Yan
    • Zheng Lian
    • Jiawang Wang
    • Fengfeng Lv
    • Yunfei Wang
    • Xufen Cao
  • View Affiliations

  • Published online on: June 14, 2018     https://doi.org/10.3892/mmr.2018.9161
  • Pages: 1955-1962
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute myocardial infarction induces ventricular remodeling, which is implicated in dilated heart and heart failure. The pathogenical mechanism of myocardium remodeling remains to be elucidated. The aim of the present study was to identify key genes and networks for myocardium remodeling following ischemia‑reperfusion (IR). First, the mRNA expression data from the National Center for Biotechnology Information database were downloaded to identify differences in mRNA expression of the IR heart at days 2 and 7. Then, weighted gene co‑expression network analysis, hierarchical clustering, protein‑protein interaction (PPI) network, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were used to identify key genes and networks for the heart remodeling process following IR. A total of 3,321 differentially expressed genes were identified during the heart remodeling process. A total of 6 modules were identified through gene co‑expression network analysis. GO and KEGG analysis results suggested that each module represented a different biological function and was associated with different pathways. Finally, hub genes of each module were identified by PPI network construction. The present study revealed that heart remodeling following IR is a complicated process, involving extracellular matrix organization, neural development, apoptosis and energy metabolism. The dysregulated genes, including SRC proto‑oncogene, non‑receptor tyrosine kinase, discs large MAGUK scaffold protein 1, ATP citrate lyase, RAN, member RAS oncogene family, tumor protein p53, and polo like kinase 2, may be essential for heart remodeling following IR and may be used as potential targets for the inhibition of heart remodeling following acute myocardial infarction.
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August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Guo N, Zhang N, Yan L, Lian Z, Wang J, Lv F, Wang Y and Cao X: Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium. Mol Med Rep 18: 1955-1962, 2018
APA
Guo, N., Zhang, N., Yan, L., Lian, Z., Wang, J., Lv, F. ... Cao, X. (2018). Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium. Molecular Medicine Reports, 18, 1955-1962. https://doi.org/10.3892/mmr.2018.9161
MLA
Guo, N., Zhang, N., Yan, L., Lian, Z., Wang, J., Lv, F., Wang, Y., Cao, X."Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium". Molecular Medicine Reports 18.2 (2018): 1955-1962.
Chicago
Guo, N., Zhang, N., Yan, L., Lian, Z., Wang, J., Lv, F., Wang, Y., Cao, X."Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium". Molecular Medicine Reports 18, no. 2 (2018): 1955-1962. https://doi.org/10.3892/mmr.2018.9161