Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2018 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2018 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis

  • Authors:
    • Sirikul Kulanuwat
    • Prapaporn Jungtrakoon
    • Watip Tangjittipokin
    • Pa‑Thai Yenchitsomanus
    • Nattachet Plengvidhya
  • View Affiliations / Copyright

    Affiliations: Siriraj Center of Research Excellence for Diabetes and Obesity, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
  • Pages: 2485-2491
    |
    Published online on: June 14, 2018
       https://doi.org/10.3892/mmr.2018.9163
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Diabetes mellitus (DM) and other glucose metabolism abnormalities are commonly observed in individuals with Fanconi anemia (FA). FA causes an impaired response to DNA damage due to genetic defects in a cluster of genes encoded proteins involved in DNA repair. However, the mechanism by which FA is associated with DM has not been clearly elucidated. Fanconi anemia complementation group C (FANCC) is a component of FA nuclear clusters. Evidence suggests that cytoplasmic FANCC has a role in protection against oxidative stress‑induced apoptosis. As oxidative stress‑mediated β‑cell dysfunction is one of the contributors to DM pathogenesis, the present study aimed to investigate the role of FANCC in pancreatic β‑cell response to oxidative stress. Small interfering RNA‑mediated FANCC suppression caused a loss of protection against oxidative stress‑induced apoptosis, and that overexpression of FANCC reduced this effect in the human 1.1B4 β‑cell line. These findings were confirmed by Annexin V‑FITC/PI staining, caspase 3/7 activity assay, and expression levels of anti‑apoptotic and pro‑apoptotic genes. Insulin and glucokinase mRNA expression were also decreased in FANCC‑depleted 1.1B4 cells. The present study demonstrated the role of FANCC in protection against oxidative stress‑induced β‑cell apoptosis and established another mechanism that associates FANCC deficiency with β‑cell dysfunction. The finding that FANCC overexpression reduced β‑cell apoptosis advances the potential for an alternative approach to the treatment of DM caused by FANCC defects.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Pagano G and Youssoufian H: Fanconi anaemia proteins: Major roles in cell protection against oxidative damage. Bioessays. 25:589–595. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, de Winter J, Joenje H, Gergely F and Patel KJ: FANCE: The link between Fanconi anaemia complex assembly and activity. EMBO J. 21:3414–3423. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Kalb R, Neveling K, Nanda I, Schindler D and Hoehn H: Fanconi anemia: Causes and consequences of genetic instability. Genome Dyn. 1:218–242. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Bagby GC Jr: Genetic basis of Fanconi anemia. Curr Opin Hemato. 10:68–76. 2003. View Article : Google Scholar

5 

de Winter JP and Joenje H: The genetic and molecular basis of Fanconi anemia. Mutat Res. 668:11–19. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Mathew CG: Fanconi anaemia genes and susceptibility to cancer. Oncogene. 25:5875–5884. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Elder DA, D'Alessio DA, Eyal O, Mueller R, Smith FO, Kansra AR and Rose SR: Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion. Pediatr Blood Cancer. 51:256–260. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Swift M, Sholman L and Gilmour D: Diabetes mellitus and the gene for Fanconi's anemia. Science. 178:308–310. 1972. View Article : Google Scholar : PubMed/NCBI

9 

Giri N, Batista DL, Alter BP and Stratakis CA: Endocrine abnormalities in patients with Fanconi anemia. J Clin Endocrinol Metab. 92:2624–2631. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Youssoufian H: Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells. Proc Natl Acad Sci USA. 91:7975–7979. 1994. View Article : Google Scholar : PubMed/NCBI

11 

Lackinger D, Ruppitsch W, Ramirez MH, Hirsch-Kauffmann M and Schweiger M: Involvement of the Fanconi anemia protein FA-C in repair processes of oxidative DNA damages. FEBS Lett. 440:103–106. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Youssoufian H: Cytoplasmic localization of FAC is essential for the correction of a prerepair defect in Fanconi anemia group C cells. J Clin Inves. 97:2003–2010. 1996. View Article : Google Scholar

13 

Cumming RC, Liu JM, Youssoufian H and Buchwald M: Suppression of apoptosis in hematopoietic factor-dependent progenitor cell lines by expression of the FAC gene. Blood. 88:4558–4567. 1996.PubMed/NCBI

14 

Hadjur S, Ung K, Wadsworth L, Dimmick J, Rajcan-Separovic E, Scott RW, Buchwald M and Jirik FR: Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase. Blood. 98:1003–1011. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Saadatzadeh MR, Bijangi-Vishehsaraei K, Hong P, Bergmann H and Haneline LS: Oxidant hypersensitivity of Fanconi anemia type C-deficient cells is dependent on a redox-regulated apoptotic pathway. J Biol Chem. 279:16805–16812. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Rathbun RK, Faulkner GR, Ostroski MH, Christianson TA, Hughes G, Jones G, Cahn R, Maziarz R, Royle G, Keeble W, et al: Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells. Blood. 90:974–985. 1997.PubMed/NCBI

17 

Cumming RC, Lightfoot J, Beard K, Youssoufian H, O'Brien PJ and Buchwald M: Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Nat Med. 7:814–820. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Kruyt FA, Hoshino T, Liu JM, Joseph P, Jaiswal AK and Youssoufian H: Abnormal microsomal detoxification implicated in Fanconi anemia group C by interaction of the FAC protein with NADPH cytochrome P450 reductase. Blood. 92:3050–3056. 1998.PubMed/NCBI

19 

Pinkus R, Weiner LM and Daniel V: Role of quinone-mediated generation of hydroxyl radicals in the induction of glutathione S-transferase gene expression. Biochemistry. 34:81–88. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Wang J, Otsuki T, Youssoufian H, Foe JL, Kim S, Devetten M, Yu J, Li Y, Dunn D and Liu JM: Overexpression of the fanconi anemia group C gene (FAC) protects hematopoietic progenitors from death induced by Fas-mediated apoptosis. Cancer Res. 58:3538–3541. 1998.PubMed/NCBI

21 

Huang F, Ben Aissa M, Magron A, Huard CC, Godin C, Lévesque G and Carreau M: The Fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis. PLoS One. 9:e928112014. View Article : Google Scholar : PubMed/NCBI

22 

Rains JL and Jain SK: Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med. 50:567–575. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Bloch-Damti A and Bashan N: Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxid Redox Signal. 7:1553–1567. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Li J, Sipple J, Maynard S, Mehta PA, Rose SR, Davies SM and Pang Q: Fanconi anemia links reactive oxygen species to insulin resistance and obesity. Antioxid Redox Signal. 17:1083–1098. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Robertson RP and Harmon JS: Pancreatic islet beta-cell and oxidative stress: The importance of glutathione peroxidase. FEBS Lett. 581:3743–3748. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Vasu S, McClenaghan NH, McCluskey JT and Flatt PR: Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia. Islets. 5:170–177. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Floros KV, Thomadaki H, Florou D, Talieri M and Scorilas A: Alterations in mRNA expression of apoptosis-related genes BCL2, BAX, FAS, caspase-3, and the novel member BCL2L12 after treatment of human leukemic cell line HL60 with the antineoplastic agent etoposide. Ann N Y Acad Sci. 1090:89–97. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Zhou Y, Li W, Xu Q and Huang Y: Elevated expression of Dickkopf-1 increases the sensitivity of human glioma cell line SHG44 to BCNU. J Exp Clin Cancer Res. 29:1312010. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Niida A, Hiroko T, Kasai M, Furukawa Y, Nakamura Y, Suzuki Y, Sugano S and Akiyama T: DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway. Oncogene. 23:8520–8526. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Tiedge M, Lortz S, Drinkgern J and Lenzen S: Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes. 46:1733–1742. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Keane KN, Cruzat VF, Carlessi R, de Bittencourt PI Jr and Newsholme P: Molecular events linking oxidative stress and inflammation to insulin resistance and β-cell dysfunction. Oxid Med Cell Longev. 2015:1816432015. View Article : Google Scholar : PubMed/NCBI

33 

Maechler P, Jornot L and Wollheim CB: Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem. 274:27905–27913. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Zraika S, Aston-Mourney K, Laybutt DR, Kebede M, Dunlop ME, Proietto J and Andrikopoulos S: The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets. Diabetologia. 49:1254–1263. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Bijangi-Vishehsaraei K, Saadatzadeh MR, Werne A, McKenzie KA, Kapur R, Ichijo H and Haneline LS: Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1. Blood. 106:4124–4130. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Zhang X, Sejas DP, Qiu Y, Williams DA and Pang Q: Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence. J Cell Sci. 120:1572–1583. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Zhang QG, Wang R, Khan M, Mahesh V and Brann DW: Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation. J Neurosci. 28:8430–8441. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Gui S, Yuan G, Wang L, Zhou L, Xue Y, Yu Y, Zhang J, Zhang M, Yang Y and Wang DW: Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2/PI3K signaling. J Cell Biochem. 114:1488–1497. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Huard CC, Tremblay CS, Helsper K, Delisle MC, Schindler D, Lévesque G and Carreau M: Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1. Blood. 121:1729–1739. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Huard CC, Tremblay CS, Magron A, Lévesque G and Carreau M: The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression. Proc Natl Acad Sci USA. 111:2152–2157. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Gloyn AL, Odili S, Buettger C, Njolstad PR, Shiota C, Matschinsky FM and Magnuson MA: Glucokinase and Glycemic Disease: From Basics to Novel Therapeutics. 16. Karger; Basel: pp. 92–109. 2004

42 

Vasu S, McClenaghan NH and Flatt PR: Molecular mechanisms of toxicity and cell damage by chemicals in a human pancreatic beta cell line, 1.1B4. Pancreas. 45:1320–1329. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC and Mirmira RG: Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: Application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem. 280:16798–16807. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Zhang C, Moriguchi T, Kajihara M, Esaki R, Harada A, Shimohata H, Oishi H, Hamada M, Morito N, Hasegawa K, et al: MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol. 25:4969–4976. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kulanuwat S, Jungtrakoon P, Tangjittipokin W, Yenchitsomanus PT and Plengvidhya N: Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis. Mol Med Rep 18: 2485-2491, 2018.
APA
Kulanuwat, S., Jungtrakoon, P., Tangjittipokin, W., Yenchitsomanus, P., & Plengvidhya, N. (2018). Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis. Molecular Medicine Reports, 18, 2485-2491. https://doi.org/10.3892/mmr.2018.9163
MLA
Kulanuwat, S., Jungtrakoon, P., Tangjittipokin, W., Yenchitsomanus, P., Plengvidhya, N."Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis". Molecular Medicine Reports 18.2 (2018): 2485-2491.
Chicago
Kulanuwat, S., Jungtrakoon, P., Tangjittipokin, W., Yenchitsomanus, P., Plengvidhya, N."Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis". Molecular Medicine Reports 18, no. 2 (2018): 2485-2491. https://doi.org/10.3892/mmr.2018.9163
Copy and paste a formatted citation
x
Spandidos Publications style
Kulanuwat S, Jungtrakoon P, Tangjittipokin W, Yenchitsomanus PT and Plengvidhya N: Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis. Mol Med Rep 18: 2485-2491, 2018.
APA
Kulanuwat, S., Jungtrakoon, P., Tangjittipokin, W., Yenchitsomanus, P., & Plengvidhya, N. (2018). Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis. Molecular Medicine Reports, 18, 2485-2491. https://doi.org/10.3892/mmr.2018.9163
MLA
Kulanuwat, S., Jungtrakoon, P., Tangjittipokin, W., Yenchitsomanus, P., Plengvidhya, N."Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis". Molecular Medicine Reports 18.2 (2018): 2485-2491.
Chicago
Kulanuwat, S., Jungtrakoon, P., Tangjittipokin, W., Yenchitsomanus, P., Plengvidhya, N."Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis". Molecular Medicine Reports 18, no. 2 (2018): 2485-2491. https://doi.org/10.3892/mmr.2018.9163
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team