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Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer

  • Authors:
    • Yu Jiang
    • Gang Liu
    • Li Zhang
    • Sheng Cheng
    • Chun Luo
    • Yang Liao
    • Shuliang Guo
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The University‑Town Hospital Affiliated to Chongqing Medical University, Chongqing 401331, P.R. China, Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, P.R. China, Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2182-2190
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    Published online on: June 14, 2018
       https://doi.org/10.3892/mmr.2018.9168
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Abstract

The aim of the present study was to investigate the effects of combination therapy of LY294002, a specific inhibitor of phosphatidylinositol 3‑kinase (PI3K), with hydrogen‑rich saline on the proliferation and apoptosis of the non‑small cell lung cancer (NSCLC) A549 cell line and the mechanisms underpinning this. Excessive production of reactive oxygen species (ROS) may induce DNA mutations, DNA damage, genomic instability and cell proliferation, and ROS are involved in several types of cancer, particularly lung cancer. In a previous study, hydrogen was recognized as an antioxidant in preventive and therapeutic applications. The PI3K/protein kinase B (Akt) pathway is an important signaling pathway that may activate downstream of a series of extracellular signals and impact on cellular processes including cell proliferation, apoptosis and survival. To date, the PI3K/Akt signaling pathway has been indicated as a feasible target for novel antineoplastic drugs. Different strategies combining the two treatment modalities have been used in cancer therapy in order to achieve an improved therapeutic response and longer control of tumor modalities control. The present study investigated the effect of hydrogen‑rich saline alone and in combination with the PI3K inhibitor, LY294002, on the proliferation, oxidative stress and apoptosis of NSCLC A549 cells. This combination therapy may be more effective than separate drug treatment; it decreased the malondialdehyde level and increased the superoxide dismutase activity. The combination therapy also enhanced the efficacy of anti‑proliferation and apoptosis. Similarly, the results of the present study demonstrated that administration of the two agents in combination may inhibit phospho‑Akt activity, and reduce expression of heme oxygenase‑1 and nuclear factor‑κB p65. The results further suggested that the combination therapy may reduce cell proliferation and promote cell apoptosis by downregulating Akt phosphorylation and inhibiting the PI3K pathway in NSCLC cell lines. Therefore, the present study provided evidence that combined therapy may be a novel therapeutic option for patients with NSCLC.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin. 57:43–66. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Yan Z, Dai Y, Fu H, Zheng Y, Bao D, Yin Y, Chen Q, Nie X, Hao Q, Hou D and Cui Y: Curcumin exerts a protective effect against premature ovarian failure in mice. J Mol Endocrinol. 60:261–271. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Duracková Z: Some current insights into oxidative stress. Physiol Res. 59:459–469. 2010.PubMed/NCBI

6 

Reuter S, Gupta SC, Chaturvedi MM and Aggarwal BB: Oxidative stress, inflammation, and cancer: How are they linked? Free Radic Biol Med. 49:1603–1616. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Visconti R and Grieco D: New insights on oxidative stress in cancer. Curr Opin Drug Discov Devel. 12:240–245. 2009.PubMed/NCBI

8 

Kinnula VL and Crapo JD: Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med. 167:1600–1619. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Esme H, Cemek M, Sezer M, Saglam H, Demir A, Melek H and Unlu M: High levels of oxidative stress in patients with advanced lung cancer. Respirology. 13:112–116. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Valavanidis A, Vlachogianni T, Fiotakis K and Loridas S: Pulmonary oxidative stress, inflammation and cancer: Respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms. Int J Environ Res Public Health. 10:3886–3907. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Møller P, Folkmann JK, Forchhammer L, Bräuner EV, Danielsen PH, Risom L and Loft S: Air pollution, oxidative damage to DNA, and carcinogenesis. Cancer Lett. 266:84–97. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Hawthorn L, Stein L, Panzarella J, Loewen GM and Baumann H: Characterization of cell-type specific profiles in tissues and isolated cells from squamous cell carcinomas of the lung. Lung Cancer. 53:129–142. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Azad N, Rojanasakul Y and Vallyathan V: Inflammation and lung cancer: Roles of reactive oxygen/nitrogen species. J Toxicol Environ Health B Crit Rev. 11:1–15. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Dillon RL, White DE and Muller WJ: The phosphatidyl inositol 3-kinase signaling network: Implications for human breast cancer. Oncogene. 26:1338–1345. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, et al: Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med. 2:26ra252010. View Article : Google Scholar : PubMed/NCBI

16 

Fry MJ: Phosphoinositide 3-kinase signalling in breast cancer: How big a role might it play? Breast Cancer Res. 3:304–312. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Martelli AM, Evangelisti C, Chappell W, Abrams SL, Bäsecke J, Stivala F, Donia M, Fagone P, Nicoletti F, Libra M, et al: Targeting the translational apparatus to improve leukemia therapy: Roles of the PI3K/PTEN/Akt/mTOR pathway. Leukemia. 25:1064–1079. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Davies MA: The role of the PI3K-AKT pathway in melanoma. Cancer J. 18:142–147. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, Franklin RA and McCubrey JA: Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy. Leukemia. 17:590–603. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Wong KK, Engelman JA and Cantley LC: Targeting the PI3K signaling pathway in cancer. Curr Opin Genet Dev. 20:87–90. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Nakao A, Toyoda Y, Sharma P, Evans M and Guthrie N: Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 46:140–149. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S and Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 13:688–694. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ and Nakao A: Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant. 8:2015–2024. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Ohta S: Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. Biochim Biophys Acta. 1820:586–594. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Takaki A, Kawai D and Yamamoto K: Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH). Int J Mol Sci. 14:20704–20728. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I and Ohta S: Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun. 361:670–674. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Chou TC: Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 58:621–681. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Desai UN, Shah KP, Mirza SH, Panchal DK, Parikh SK and Rawal RM: Enhancement of the cytotoxic effects of Cytarabine in synergism with Hesperidine and Silibinin in Acute Myeloid Leukemia: An in-vitro approach. J Cancer Res Ther. 11:352–357. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Barreiro E, Fermoselle C, Mateu-Jimenez M, Sánchez-Font A, Pijuan L, Gea J and Curull V: Oxidative stress and inflammation in the normal airways and blood of patients with lung cancer and COPD. Free Radic Biol Med. 65:859–871. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Khansari N, Shakiba Y and Mahmoudi M: Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov. 3:73–80. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Glasauer A and Chandel NS: Targeting antioxidants for cancer therapy. Biochem Pharmacol. 92:90–101. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Ames BN and Gold LS: Animal cancer tests and cancer prevention. J Natl Cancer Inst Monogr. 125–132. 1992.PubMed/NCBI

34 

Guyton KZ and Kensler TW: Oxidative mechanisms in carcinogenesis. Br Med Bull. 49:523–544. 1993. View Article : Google Scholar : PubMed/NCBI

35 

Schulte-Hermann R, Timmermann-Trosiener I, Barthel G and Bursch W: DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Cancer Res. 50:5127–5135. 1990.PubMed/NCBI

36 

Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaja KL, Jiang J, Stevenson DE and Walborg EF Jr: The role of oxidative stress in chemical carcinogenesis. Environ Health Perspect. 106 Suppl 1:S289–S295. 1998. View Article : Google Scholar

37 

Strak M, Janssen NA, Godri KJ, Gosens I, Mudway IS, Cassee FR, Lebret E, Kelly FJ, Harrison RM, Brunekreef B, et al: Respiratory health effects of airborne particulate matter: The role of particle size, composition, and oxidative potential-the RAPTES project. Environ Health Perspect. 120:1183–1189. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Wood KC and Gladwin MT: The hydrogen highway to reperfusion therapy. Nat Med. 13:673–674. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Chen H, Sun YP, Li Y, Liu WW, Xiang HG, Fan LY, Sun Q, Xu XY, Cai JM, Ruan CP, et al: Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun. 393:308–313. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Chen HG, Xie KL, Han HZ, Wang WN, Liu DQ, Wang GL and Yu YH: Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. Int J Surg. 11:1060–1066. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Xie K, Yu Y, Huang Y, Zheng L, Li J, Chen H, Han H, Hou L, Gong G and Wang G: Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock. 37:548–555. 2012.PubMed/NCBI

42 

Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, et al: Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 28:137–143. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Huang CS, Kawamura T, Toyoda Y and Nakao A: Recent advances in hydrogen research as a therapeutic medical gas. Free Radic Res. 44:971–982. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Wang C, Li J, Liu Q, Yang R, Zhang JH, Cao YP and Sun XJ: Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease. Neurosci Lett. 491:127–132. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Sass G, Leukel P, Schmitz V, Raskopf E, Ocker M, Neureiter D, Meissnitzer M, Tasika E, Tannapfel A and Tiegs G: Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Int J Cancer. 123:1269–1277. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Nitti M, Piras S, Marinari UM, Moretta L, Pronzato MA and Furfaro AL: HO-1 induction in cancer progression: A matter of cell adaptation. Antioxidants (Basel). 6:pii: E29. 2017.PubMed/NCBI

47 

Lien GS, Wu MS, Bien MY, Chen CH, Lin CH and Chen BC: Epidermal growth factor stimulates nuclear factor-κB activation and heme oxygenase-1 expression via c-Src, NADPH oxidase, PI3K, and Akt in human colon cancer cells. PLoS One. 9:e1048912014. View Article : Google Scholar : PubMed/NCBI

48 

Was H, Dulak J and Jozkowicz A: Heme oxygenase-1 in tumor biology and therapy. Curr Drug Targets. 11:1551–1570. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Goodman AI, Choudhury M, da Silva JL, Schwartzman ML and Abraham NG: Overexpression of the heme oxygenase gene in renal cell carcinoma. Proc Soc Exp Biol Med. 214:54–61. 1997. View Article : Google Scholar : PubMed/NCBI

50 

Engelman JA: Targeting PI3K signalling in cancer: Opportunities, challenges and limitations. Nat Rev Cancer. 9:550–562. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Schmidt M, Hövelmann S and Beckers TL: A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis. Br J Cancer. 87:924–932. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Liu G, Zhang L, Cheng S, Luo C, Liao Y and Guo S: Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer. Mol Med Rep 18: 2182-2190, 2018.
APA
Jiang, Y., Liu, G., Zhang, L., Cheng, S., Luo, C., Liao, Y., & Guo, S. (2018). Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer. Molecular Medicine Reports, 18, 2182-2190. https://doi.org/10.3892/mmr.2018.9168
MLA
Jiang, Y., Liu, G., Zhang, L., Cheng, S., Luo, C., Liao, Y., Guo, S."Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer". Molecular Medicine Reports 18.2 (2018): 2182-2190.
Chicago
Jiang, Y., Liu, G., Zhang, L., Cheng, S., Luo, C., Liao, Y., Guo, S."Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer". Molecular Medicine Reports 18, no. 2 (2018): 2182-2190. https://doi.org/10.3892/mmr.2018.9168
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Liu G, Zhang L, Cheng S, Luo C, Liao Y and Guo S: Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer. Mol Med Rep 18: 2182-2190, 2018.
APA
Jiang, Y., Liu, G., Zhang, L., Cheng, S., Luo, C., Liao, Y., & Guo, S. (2018). Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer. Molecular Medicine Reports, 18, 2182-2190. https://doi.org/10.3892/mmr.2018.9168
MLA
Jiang, Y., Liu, G., Zhang, L., Cheng, S., Luo, C., Liao, Y., Guo, S."Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer". Molecular Medicine Reports 18.2 (2018): 2182-2190.
Chicago
Jiang, Y., Liu, G., Zhang, L., Cheng, S., Luo, C., Liao, Y., Guo, S."Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer". Molecular Medicine Reports 18, no. 2 (2018): 2182-2190. https://doi.org/10.3892/mmr.2018.9168
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