Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation

  • Authors:
    • Qiang Liu
    • Qingshan Wang
    • Haibin Li
  • View Affiliations

  • Published online on: June 26, 2018     https://doi.org/10.3892/mmr.2018.9221
  • Pages: 2365-2372
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Abstract

The aim of the present study was to investigate the effect of embelin on abdominal aortic aneurysm (AAA). AAA model mice were induced by chronic infusion of 1,000 ng/kg/min Angiotensin II. AAA model mice were treated with 25, 50 or 100 mg/kg embelin for 28 days. Embelin inhibited tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6, IL‑18 and malondialdehyde (MDA) level activities, increased superoxide dismutase, glutathione (GSH) and GSH peroxidase level activities and inhibited MDA level activities in AAA mice Embelin suppressed the secretion of matrix metalloproteinase‑9 protein expression, monocyte chemoattractant protein‑2 activity and epithelial neutrophil‑activating peptide expression levels in AAA mice. Embelin suppressed phosphorylated‑signal transducer and activator of transcription (STAT) 3, phosphorylated‑p38 mitogen‑activated protein kinase and nuclear factor (NF)‑κB protein expression in AAA mice. These findings indicate that embelin inhibits AAA through decreasing IL‑6‑induced STAT3, and NF‑κB inactivation.
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August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Liu Q, Wang Q and Li H: Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation. Mol Med Rep 18: 2365-2372, 2018
APA
Liu, Q., Wang, Q., & Li, H. (2018). Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation. Molecular Medicine Reports, 18, 2365-2372. https://doi.org/10.3892/mmr.2018.9221
MLA
Liu, Q., Wang, Q., Li, H."Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation". Molecular Medicine Reports 18.2 (2018): 2365-2372.
Chicago
Liu, Q., Wang, Q., Li, H."Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation". Molecular Medicine Reports 18, no. 2 (2018): 2365-2372. https://doi.org/10.3892/mmr.2018.9221