Association between the HMGB1/TLR4 signaling pathway and the clinicopathological features of ovarian cancer

  • Authors:
    • Caixia Jiang
    • Xiaoyan Qu
    • Huihui Ke
    • Wei Gong
    • Rong Chen
    • Weihong Yang
    • Zhongping Cheng
  • View Affiliations

  • Published online on: July 10, 2018     https://doi.org/10.3892/mmr.2018.9271
  • Pages: 3093-3098
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Abstract

In the present study, the expression levels of high‑mobility group protein B1 (HMGB1), Toll‑like receptor 4 (TLR4), nuclear factor (NF)‑κB and tumor necrosis factor (TNF)‑α in malignant epithelial ovarian cancer (MEOC) were investigated in regards to several clinicopathological characteristics. A total of 20 patients with MEOC who underwent surgery were recruited in the present study. The mRNA and protein expression of HMGB1, TLR4, NF‑κB and TNF‑α was determined in patients with MEOC and compared with expression levels in 20 patients diagnosed with benign ovarian cysts (BOC). It was demonstrated that the mRNA and protein expression of HMGB1, TLR4, NF‑κB and TNF‑α in MEOC was significantly increased, compared with the BOC group (P<0.01). The gene and protein expression of HMGB1, TLR4, NF‑κB and TNF‑α was significantly increased in the advanced tumor stage and poorly differentiated group (P<0.01). The present study suggested that the HMGB1/TLR4 signaling pathway was overactive in MEOC, and was associated with MEOC tumor cell proliferation, invasion and metastasis. Furthermore, this may have been mediated via NF‑κB signaling.
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September-2018
Volume 18 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jiang C, Qu X, Ke H, Gong W, Chen R, Yang W and Cheng Z: Association between the HMGB1/TLR4 signaling pathway and the clinicopathological features of ovarian cancer. Mol Med Rep 18: 3093-3098, 2018.
APA
Jiang, C., Qu, X., Ke, H., Gong, W., Chen, R., Yang, W., & Cheng, Z. (2018). Association between the HMGB1/TLR4 signaling pathway and the clinicopathological features of ovarian cancer. Molecular Medicine Reports, 18, 3093-3098. https://doi.org/10.3892/mmr.2018.9271
MLA
Jiang, C., Qu, X., Ke, H., Gong, W., Chen, R., Yang, W., Cheng, Z."Association between the HMGB1/TLR4 signaling pathway and the clinicopathological features of ovarian cancer". Molecular Medicine Reports 18.3 (2018): 3093-3098.
Chicago
Jiang, C., Qu, X., Ke, H., Gong, W., Chen, R., Yang, W., Cheng, Z."Association between the HMGB1/TLR4 signaling pathway and the clinicopathological features of ovarian cancer". Molecular Medicine Reports 18, no. 3 (2018): 3093-3098. https://doi.org/10.3892/mmr.2018.9271