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Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats

  • Authors:
    • Rong Wu
    • Ping‑An Yao
    • Hui‑Lin Wang
    • Yan Gao
    • Hai‑Lun Yu
    • Lei Wang
    • Xiao‑Hua Cui
    • Xu Xu
    • Jian‑Ping Gao
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China, Department of Chemical and Environmental Engineering, School of Shanghai Institute of Technology, Shanghai 201418, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3229-3241
    |
    Published online on: July 24, 2018
       https://doi.org/10.3892/mmr.2018.9310
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Abstract

Cordyceps sinensis (CS) is a prominent medicinal herb in traditional Chinese medicine, and fermented CS is frequently used as a substitute for natural CS. Doxorubicin (DOX), an antitumor drug used in chemotherapy, is limited by its poor cardiotoxicity. The aim of the present study was to evaluate the protective effect of fermented CS against DOX‑induced cardiotoxicity and the potential underlying mechanisms. Male Sprague‑Dawley rats (180‑200 g) were randomly assigned to seven different treatment groups: Normal control, DOX control, DOX+captopril (0.05 g/kg), 0.75, 1.5 and 3 g/kg DOX+CS, and the CS (1.5 g/kg) control. Histopathological changes, cardiac energy metabolism, cyclic adenosine monophosphate (cAMP) signaling and the associated mRNA expression of AMP‑activated protein kinase (AMPK) were then evaluated. Fermented CS decreased the left ventricular weight index, heart weight index and mortality; however, it increased diastolic blood pressure and mean arterial pressure. In addition, it shortened the duration of the QRS complex and Sα‑T segment, decreased serum creatine kinase (CK) and aspartate aminotransferase activity, inhibited histopathological changes and reduced brain natriuretic peptide content. Treatment with fermented CS also increased the activities of superoxide dismutase and glutathione peroxidase, reduced malondialdehyde content, increased the mitochondrial activities of Na+K+‑adenosine 5'‑triphosphate (ATP) ase, Ca2+Mg2+‑ATPase and CK, and increased the creatine phosphate/ATP ratio and AMP/ATP ratio. Furthermore, it decreased the ATP/adenosine 5'‑diphosphate (ADP) ratio, upregulated AMPKα2 expression, reduced the activity of serum phosphodiesterases (PDEs) and increased myocardial cAMP content. The results of the present study demonstrated that fermented CS attenuated DOX‑induced cardiotoxicity by inhibiting myocardial hypertrophy and myocardial damage, ameliorating systolic function and the antioxidant enzyme system, improving cardiac energy metabolism, depressing the activities of PDEs, and by upregulating the cAMP and AMPK signaling pathways. Thus, fermented CS may be a candidate for the prevention of DOX‑induced cardiotoxicity, cardiac energy impairment and against a number of cardiac diseases.
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View References

1 

Octavia Y, Tocchetti CG, Gabrielson KL, Janssens S, Crijns HJ and Moens AL: Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol. 52:1213–1225. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS and Moreira PI: Doxorubicin: The good, the bad and the ugly effect. Curr Med Chem. 16:3267–3285. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Parker MA, King V and Howard KP: Nuclear magnetic resonance study of doxorubicin binding to cardiolipin containing magnetically oriented phospholipid bilayers. Biochim Biophys Acta. 1514:206–216. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Wu R, Gao JP, Wang HL, Gao Y, Wu Q and Cui XH: Effects of fermented Cordyceps sinensis on oxidative stress in doxorubicin treated rats. Pharmacogn Mag. 11:724–731. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Tokarska-Schlattner M, Wallimann T and Schlattner U: Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin. C R Biol. 329:657–668. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Lebrecht D, Setzer B, Ketelsen UP, Haberstroh J and Walker UA: Time-dependent and tissue-specific accumulation of mtDNA and respiratory chain defects in chronic doxorubicin cardiomyopathy. Circulation. 108:2423–2429. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Li SP, Li P, Lai CM, Gong YX, Kan KK, Dong TT, Tsim KW and Wang YT: Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurised liquid extraction and high-performance liquid chromatography. J Chromatogr A. 1036:239–243. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Zhu JS, Halpern GM and Jones K: The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: Part I. J Altern Complement Med. 4:289–303. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Lo HC, Hsu TH, Tu ST and Lin KC: Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin. Am J Chin Med. 34:819–832. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Ji J, Liu J, Liu H and Wang Y: Effects of fermented mushroom of cordyceps sinensis, rich in selenium, on uterine cervix cancer. Evid Based Complement Alternat Med. 2014:1731802014. View Article : Google Scholar : PubMed/NCBI

11 

Lin XX, Xie QM, Shen WH and Chen Y: Effects of fermented Cordyceps powder on pulmonary function in sensitized guinea pigs and airway inflammation in sensitized rats. Zhongguo Zhong Yao Za Zhi. 26:622–625. 2001.(In Chinese). PubMed/NCBI

12 

National Pharmacopoeia Committee: Pharmacopoeia of the people's Republic of China. China Medical Science Press; Beijing: pp. 832–833. 2015

13 

Council NR: Guide for the care and use of laboratory animals. The National Academies Press; Washington, DC: 1996

14 

Xiao J, Sun GB, Sun B, Wu Y, He L, Wang X, Chen RC, Cao L, Ren XY and Sun XB: Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. Toxicology. 292:53–62. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Danesi R, Del Tacca M and Soldani G: Measurement of the S alpha T segment as the most reliable electrocardiogram parameter for the assessment of adriamycin-induced cardiotoxicity in the rat. J Pharmacol Methods. 16:251–259. 1986. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Kelishomi RB, Ejtemaeemehr S, Tavangar SM, Rahimian R, Mobarakeh JI and Dehpour AR: Morphine is protective against doxorubicin-induced cardiotoxicity in rat. Toxicology. 243:96–104. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Herman EH, Zhang J, Chadwick DP and Ferrans VJ: Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats. Cancer Chemother Pharmacol. 45:329–334. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Rossi F, Filippelli W, Russo S, Filippelli A and Berrino L: Cardiotoxicity of doxorubicin: Effects of drugs inhibiting the release of vasoactive substances. Pharmacol Toxicol. 75:99–107. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Yan XF, Zhang ZM, Yao HY, Guan Y, Zhu JP, Zhang LH, Jia YL and Wang RW: Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors. Phytother Res. 27:1597–1604. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Liu X, Zhong F, Tang XL, Lian FL, Zhou Q, Guo SM, Liu JF, Sun P, Hao X, Lu Y, et al: Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: A metabolomic analysis. Acta Pharmacol Sin. 35:697–706. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Ahmed LA and El-Maraghy SA: Nicorandil ameliorates mitochondrial dysfunction in doxorubicin-induced heart failure in rats: Possible mechanism of cardioprotection. Biochem Pharmacol. 86:1301–1310. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Schillaci G, Verdecchia P, Porcellati C, Cuccurullo O, Cosco C and Perticone F: Continuous relation between left ventricular mass and cardiovascular risk in essential hypertension. Hypertension. 35:580–586. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Kuzman JA, O'Connell TD and Gerdes AM: Rapamycin prevents thyroid hormone-induced cardiac hypertrophy. Endocrinology. 148:3477–3484. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Almeida AL and dos Santos Júnior EG: Subclinical ventricular dysfunction detected by speckle-tracking two years after use of anthracycline-reply. Arq Bras Cardiol. 105:2072015.PubMed/NCBI

26 

Tassan-Mangina S, Codorean D, Metivier M, Costa B, Himberlin C, Jouannaud C, Blaise AM, Elaerts J and Nazeyrollas P: Tissue Doppler imaging and conventional echocardiography after anthracycline treatment in adults: Early and late alterations of left ventricular function during a prospective study. Eur J Echocardiogr. 7:141–146. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Ozdogan K, Taskin E and Dursun N: Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats. Anadolu Kardiyol Derg. 11:3–10. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Weinberg LE and Singal PK: Refractory heart failure and age-related differences in adriamycin-induced myocardial changes in rats. Can J Physiol Pharmacol. 65:1957–1965. 1987. View Article : Google Scholar : PubMed/NCBI

29 

Guo X, Xue M, Li CJ, Yang W, Wang SS, Ma ZJ, Zhang XN, Wang XY, Zhao R, Chang BC and Chen LM: Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy. J Ethnopharmacol. 193:333–344. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Larsen RL, Jakacki RI, Vetter VL, Meadows AT, Silber JH and Barber G: Electrocardiographic changes and arrhythmias after cancer therapy in children and young adults. Am J Cardiol. 70:73–77. 1992. View Article : Google Scholar : PubMed/NCBI

31 

Villani F, Galimberti M, Monti E, Cova D, Lanza E, Rozza-Dionigi A, Favalli L and Poggi P: Effect of ICRF-187 pretreatment against doxorubicin-induced delayed cardiotoxicity in the rat. Toxicol Appl Pharmacol. 102:292–299. 1990. View Article : Google Scholar : PubMed/NCBI

32 

Bagai A, Schulte PJ, Granger CB, Mahaffey KW, Christenson RH, Bell G, Lopes RD, Green CL, Lincoff AM, Armstrong PW and Roe MT: Prognostic implications of creatine kinase-MB measurements in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention. Am Hear J. 168(503–511): e22014.

33 

Pongprot Y, Sittiwangkul R, Charoenkwan P and Silvilairat S: Use of cardiac markers for monitoring of doxorubixin-induced cardiotoxicity in children with cancer. J Pediatr Hematol Oncol. 34:589–595. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Abdel-Raheem IT, Taye A and Abouzied MM: Cardioprotective effects of nicorandil, a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol. 113:158–166. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Desai AS, Lewis EF, Li R, Solomon SD, Assmann SF, Boineau R, Clausell N, Diaz R, Fleg JL, Gordeev I, et al: Rationale and design of the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial: A randomized, controlled study of spironolactone in patients with symptomatic heart failure and preserved ejection fraction. Am Hear J. 162(966–972): e102011.

36 

Zhang Y, Chen Y, Zhang M, Tang Y, Xie Y, Huang X and Li Y: Doxorubicin induces sarcoplasmic reticulum calcium regulation dysfunction via the decrease of SERCA2 and phospholamban expressions in rats. Cell Biochem Biophys. 70:1791–1798. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Forgione MA, Cap A, Liao R, Moldovan NI, Eberhardt RT, Lim CC, Jones J, Goldschmidt-Clermont PJ and Loscalzo J: Heterozygous cellular glutathione peroxidase deficiency in the mouse: Abnormalities in vascular and cardiac function and structure. Circulation. 106:1154–1158. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Sharma M, Kishore K, Gupta SK, Joshi S and Arya DS: Cardioprotective potential of ocimum sanctum in isoproterenol induced myocardial infarction in rats. Mol Cell Biochem. 225:75–83. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Traverso N, Menini S, Maineri EP, Patriarca S, Odetti P, Cottalasso D, Marinari UM and Pronzato MA: Malondialdehyde, a lipoperoxidation-derived aldehyde, can bring about secondary oxidative damage to proteins. J Gerontol A Biol Sci Med Sci. 59:B890–B895. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Anwar S, Khan MA, Sadaf A and Younus H: A structural study on the protection of glycation of superoxide dismutase by thymoquinone. Int J Biol Macromol. 69:476–481. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Martin SS and Senior AE: Membrane adenosine triphosphatase activities in rat pancreas. Biochim Biophys Acta. 602:401–418. 1980. View Article : Google Scholar : PubMed/NCBI

42 

Tokarska-Schlattner M, Zaugg M, Zuppinger C, Wallimann T and Schlattner U: New insights into doxorubicin-induced cardiotoxicity: The critical role of cellular energetics. J Mol Cell Cardiol. 41:389–405. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Azevedo PS, Minicucci MF, Santos PP, Paiva SA and Zornoff LA: Energy metabolism in cardiac remodeling and heart failure. Cardiol Rev. 21:135–140. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Brautbar N, Baczynski R, Carpenter C, Moser S, Geiger P, Finander P and Massry SG: Impaired energy metabolism in rat myocardium during phosphate depletion. Am J Physiol. 242:F699–F704. 1982.PubMed/NCBI

45 

Maldonado EN and Lemasters JJ: ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect. Mitochondrion. 19:78–84. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Amorim PA, Nguyen TD, Schwarzer M, Mohr FW, Schrepper A and Doenst T: Myocardial infarction in rats causes partial impairment in insulin response associated with reduced fatty acid oxidation and mitochondrial gene expression. J Thorac Cardiovasc Surg. 140:1160–1167. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Kato T, Niizuma S, Inuzuka Y, Kawashima T, Okuda J, Tamaki Y, Iwanaga Y, Narazaki M, Matsuda T, Soga T, et al: Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure. Circ Hear Fail. 3:420–430. 2010. View Article : Google Scholar

48 

Brennan JP, Southworth R, Medina RA, Davidson SM, Duchen MR and Shattock MJ: Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation. Cardiovasc Res. 72:313–321. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Gowans GJ and Hardie DG: AMPK: A cellular energy sensor primarily regulated by AMP. Biochem Soc Trans. 42:71–75. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Gao S, Li H, Feng XJ, Li M, Liu ZP, Cai Y, Lu J, Huang XY, Wang JJ, Li Q, et al: α-Enolase plays a catalytically independent role in doxorubicin-induced cardiomyocyte apoptosis and mitochondrial dysfunction. J Mol Cell Cardiol. 79:92–103. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Braissant O, Foufelle F, Scotto C, Dauca M and Wahli W: Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta and -gamma in the adult rat. Endocrinology. 137:354–366. 1996. View Article : Google Scholar : PubMed/NCBI

52 

Karbowska J, Kochan Z and Smolenski RT: Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart. Cell Mol Biol Lett. 8:49–53. 2003.PubMed/NCBI

53 

Chen WL, Chen YL, Chiang YM, Wang SG and Lee HM: Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoxO1/ATGL pathway. Biochem Pharmacol. 84:522–531. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC and Spiegelman BM: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 98:115–124. 1999. View Article : Google Scholar : PubMed/NCBI

55 

Finck BN and Kelly DP: PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease. J Clin Invest. 116:615–622. 2006. View Article : Google Scholar : PubMed/NCBI

56 

Tang DX, Zhao HP, Pan CS, Liu YY, Wei XH, Yang XY, Chen YY, Fan JY, Wang CS, Han JY and Li PP: QiShenYiQi Pills, a compound chinese medicine, ameliorates doxorubicin-induced myocardial structure damage and cardiac dysfunction in rats. Evid Based Complement Altern Med. 2013:4805972013. View Article : Google Scholar

57 

Perera RK and Nikolaev VO: Compartmentation of cAMP signalling in cardiomyocytes in health and disease. Acta Physiol (Oxf). 207:650–662. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Meier S, Andressen KW, Aronsen JM, Sjaastad I, Hougen K, Skomedal T, Osnes JB, Qvigstad E, Levy FO and Moltzau LR: PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. Eur J Pharmacol. 812:174–183. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Levy FO: Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility. Naunyn Schmiedebergs Arch Pharmacol. 386:665–670. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Guo L, Luo L, Ju R, Chen C, Zhu L, Li J, Yu X, Ye C and Zhang D: Carboxyamidotriazole: A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases. Eur J Pharmacol. 746:14–21. 2015. View Article : Google Scholar : PubMed/NCBI

61 

Li LX, Cheng YF, Lin HB, Wang C, Xu JP and Zhang HT: Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. Metab Brain Dis. 26:37–47. 2011. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Wu R, Yao PA, Wang HL, Gao Y, Yu HL, Wang L, Cui XH, Xu X and Gao JP: Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats. Mol Med Rep 18: 3229-3241, 2018.
APA
Wu, R., Yao, P., Wang, H., Gao, Y., Yu, H., Wang, L. ... Gao, J. (2018). Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats. Molecular Medicine Reports, 18, 3229-3241. https://doi.org/10.3892/mmr.2018.9310
MLA
Wu, R., Yao, P., Wang, H., Gao, Y., Yu, H., Wang, L., Cui, X., Xu, X., Gao, J."Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats". Molecular Medicine Reports 18.3 (2018): 3229-3241.
Chicago
Wu, R., Yao, P., Wang, H., Gao, Y., Yu, H., Wang, L., Cui, X., Xu, X., Gao, J."Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats". Molecular Medicine Reports 18, no. 3 (2018): 3229-3241. https://doi.org/10.3892/mmr.2018.9310
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Spandidos Publications style
Wu R, Yao PA, Wang HL, Gao Y, Yu HL, Wang L, Cui XH, Xu X and Gao JP: Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats. Mol Med Rep 18: 3229-3241, 2018.
APA
Wu, R., Yao, P., Wang, H., Gao, Y., Yu, H., Wang, L. ... Gao, J. (2018). Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats. Molecular Medicine Reports, 18, 3229-3241. https://doi.org/10.3892/mmr.2018.9310
MLA
Wu, R., Yao, P., Wang, H., Gao, Y., Yu, H., Wang, L., Cui, X., Xu, X., Gao, J."Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats". Molecular Medicine Reports 18.3 (2018): 3229-3241.
Chicago
Wu, R., Yao, P., Wang, H., Gao, Y., Yu, H., Wang, L., Cui, X., Xu, X., Gao, J."Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats". Molecular Medicine Reports 18, no. 3 (2018): 3229-3241. https://doi.org/10.3892/mmr.2018.9310
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