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Article

Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway

  • Authors:
    • Yan Zhang
    • Baoguang Qiao
    • Fei Gao
    • Haifeng Wang
    • Shaohua Miao
    • Huan Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Heze Municipal Hospital, Heze, Shandong 274031, P.R. China
  • Pages: 3497-3505
    |
    Published online on: July 24, 2018
       https://doi.org/10.3892/mmr.2018.9315
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Abstract

Melatonin can protect against cardiac ischemia/reperfusion (I/R) injury in models in vitro and in vivo by regulating oxidative stress and apoptosis; however, the precise molecular mechanisms involved remain unclear. Nuclear factor erythroid 2‑related factor 2 (Nrf2) is a transcription factor, which has been associated with the regulation of oxidative stress by translocating to the nucleus. Therefore, the present study investigated whether activation of the Nrf2 signaling pathway may be responsible for the protective effects of melatonin on I/R‑injured cardiomyocytes. In the present study, H9c2 cells were subjected to simulated I/R (SIR) injury and pretreated with melatonin and/or Nrf2 small interfering RNA (siRNA). Cell viability was detected via Cell Counting kit‑8 assay, apoptosis was examined by caspase‑3 cleavage and activity analysis; oxidative stress levels were determined by specific activity analysis assays. In the present study, it was observed that SIR induced significant increases in apoptosis and oxidative stress, and enhanced Nrf2 expression within H9c2 cells. Pretreatment with melatonin partially reversed these alterations and promoted Nrf2 nuclear translocation. Transfection with Nrf2 siRNA inhibited the protective effects of melatonin on SIR‑induced H9c2 cells. These results indicated that melatonin may protect H9c2 cells against I/R injury by reducing apoptosis and oxidative stress; this effect may be mediated via activation of the Nrf2 signaling pathway. Collectively, the results of the present study may suggest melatonin as a potential therapeutic agent against cardiac I/R injury.
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1 

Zhang X, Hu H, Luo J, Deng H, Yu P, Zhang Z, Zhang G, Shan L and Wang Y: A novel danshensu-tetramethylpyrazine conjugate DT-010 provides cardioprotection through the PGC-1α/Nrf2/HO-1 pathway. Biol Pharm Bull. 40:1490–1498. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Hu T, Wei G, Xi M, Yan J, Wu X, Wang Y, Zhu Y, Wang C and Wen A: Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway. Int J Mol Med. 38:83–94. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Zhang C, He S, Li Y, Li F, Liu Z, Liu J and Gong J: Bisoprolol protects myocardium cells against ischemia/reperfusion injury by attenuating unfolded protein response in rats. Sci Rep. 7:118592017. View Article : Google Scholar : PubMed/NCBI

4 

Liu J, Sui H, Zhao J and Wang Y: Osmotin protects H9c2 cells from simulated ischemia-reperfusion injury through AdipoR1/PI3K/AKT signaling pathway. Front Physiol. 8:6112017. View Article : Google Scholar : PubMed/NCBI

5 

Sinning C, Westermann D and Clemmensen P: Oxidative stress in ischemia and reperfusion: Current concepts, novel ideas and future perspectives. Biomark Med. 11:11031–11040. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Lim SH and Lee J: Xyloglucan intake attenuates myocardial injury by inhibiting apoptosis and improving energy metabolism in a rat model of myocardial infarction. Nutr Res. 45:19–29. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Toldo S, Marchetti C, Mauro AG, Chojnacki J, Mezzaroma E, Carbone S, Zhang S, Van Tassell B, Salloum FN and Abbate A: Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse. Int J Cardiol. 209:215–220. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Wu SZ, Tao LY, Wang JN, Xu ZQ, Wang J, Xue YJ, Huang KY, Lin JF, Li L and Ji KT: Amifostine pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis and oxidative stress. Oxid Med Cell Longev. 2017:41308242017. View Article : Google Scholar : PubMed/NCBI

9 

Liu YF, Chu YY, Zhang XZ, Zhang M, Xie FG, Zhou M, Wen HH and Shu AH: TGFβ1 protects myocardium from apoptosis and oxidative damage after ischemia reperfusion. Eur Rev Med Pharmacol Sci. 21:1551–1558. 2017.PubMed/NCBI

10 

Baltatu OC, Amaral FG, Campos LA and Cipolla-Neto J: Melatonin, mitochondria and hypertension. Cell Mol Life Sci. 74:3955–3964. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Guo Y, Sun J, Li T, Zhang Q, Bu S, Wang Q and Lai D: Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-κB/iNOS and Nrf2/HO-1 signaling pathway. Sci Rep. 7:95992017. View Article : Google Scholar : PubMed/NCBI

12 

Wang Z, Zhou F, Dou Y, Tian X, Liu C, Li H, Shen H and Chen G: Melatonin alleviates intracerebral hemorrhage-induced secondary brain injury in rats via suppressing apoptosis, inflammation, oxidative stress, DNA damage, and mitochondria injury. Transl Stroke Res. 9:74–91. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Bai XZ, He T, Gao JX, Liu Y, Liu JQ, Han SC, Li Y, Shi JH, Han JT, Tao K, et al: Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1. Sci Rep. 6:321992016. View Article : Google Scholar : PubMed/NCBI

14 

Yu L, Gong B, Duan W, Fan C, Zhang J, Li Z, Xue X, Xu Y, Meng D, Li B, et al: Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: Role of AMPK-PGC-1α-SIRT3 signaling. Sci Rep. 7:413372017. View Article : Google Scholar : PubMed/NCBI

15 

Yu L, Sun Y, Cheng L, Jin Z, Yang Y, Zhai M, Pei H, Wang X, Zhang H, Meng Q, et al: Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: Role of SIRT1. J Pineal Res. 57:228–238. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Lian Y, Xia X, Zhao H and Zhu Y: The potential of chrysophanol in protecting against high fat-induced cardiac injury through Nrf2-regulated anti-inflammation, anti-oxidant and anti-fibrosis in Nrf2 knockout mice. Biomed Pharmacother. 93:1175–1189. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Dludla PV, Muller CJ, Joubert E, Louw J, Essop MF, Gabuza KB, Ghoor S, Huisamen B and Johnson R: Aspalathin protects the heart against hyperglycemia-induced oxidative damage by Up-regulating Nrf2 expression. Molecules. 22:pii: E129. 2017. View Article : Google Scholar

18 

Bai Y, Chen Q, Sun YP, Wang X, Lv L, Zhang LP, Liu JS, Zhao S and Wang XL: Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation. Cardiovasc Ther. 35:2017. View Article : Google Scholar : PubMed/NCBI

19 

Zeng C, Zhong P, Zhao Y, Kanchana K, Zhang Y, Khan ZA, Chakrabarti S, Wu L, Wang J and Liang G: Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo. J Mol Cell Cardiol. 79:1–12. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Li W, Wu M, Tang L, Pan Y, Liu Z, Zeng C, Wang J, Wei T and Liang G: Novel curcumin analogue 14p protects against myocardial ischemia reperfusion injury through Nrf2-activating anti-oxidative activity. Toxicol Appl Pharmacol. 282:175–183. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Cui G, Luk SC, Li RA, Chan KK, Lei SW, Wang L, Shen H, Leung GP and Lee SM: Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway. J Cardiovasc Pharmacol. 65:39–46. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Chen RC, Sun GB, Wang J, Zhang HJ and Sun XB: Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. Food Funct. 6:1331–1344. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Han H, Hu J, Yan Q, Zhu J, Zhu Z, Chen Y, Sun J and Zhang R: Bone marrow-derived mesenchymal stem cells rescue injured H9c2 cells via transferring intact mitochondria through tunneling nanotubes in an in vitro simulated ischemia/reperfusion model. Mol Med Rep. 13:1517–1524. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Xu J, Li C, Li Z, Yang C, Lei L, Ren W, Su Y and Chen C: Protective effects of oxymatrine against lipopolysaccharide/D-galactosamine-induced acute liver failure through oxidative damage, via activation of Nrf2/HO-1 and modulation of inflammatory TLR4-signaling pathways. Mol Med Rep. 17:1907–1912. 2018.PubMed/NCBI

25 

Zhai M, Li B, Duan W, Jing L, Zhang B, Zhang M, Yu L, Liu Z, Yu B, Ren K, et al: Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. J Pineal Res. 63:2017. View Article : Google Scholar

26 

Yeung HM, Hung MW and Fung ML: Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats. J Pineal Res. 45:373–382. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Hu ZP, Fang XL, Fang N, Wang XB, Qian HY, Cao Z, Cheng Y, Wang BN and Wang Y: Melatonin ameliorates vascular endothelial dysfunction, inflammation, and atherosclerosis by suppressing the TLR4/NF-κB system in high-fat-fed rabbits. J Pineal Res. 55:388–398. 2013.PubMed/NCBI

28 

Shao G, Zhang S, Nie J, Li J and Tong J: Effects of melatonin on mechanisms involved in hypertension using human umbilical vein endothelial cells. J Toxicol Environ Health A. 80:1342–1348. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Guo Y, Li Z, Shi C, Li J, Yao M and Chen X: Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway. Int J Mol Med. 40:999–1008. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Satta S, Mahmoud AM, Wilkinson FL, Alexander Yvonne M and White SJ: The role of Nrf2 in cardiovascular function and disease. Oxid Med Cell Longev. 2017:92372632017. View Article : Google Scholar : PubMed/NCBI

31 

Ding Y, Chen M, Wang M, Li Y and Wen A: Posttreatment with 11-Keto-β-boswellic acid ameliorates cerebral ischemia-reperfusion injury: Nrf2/HO-1 pathway as a potential mechanism. Mol Neurobiol. 52:1430–1439. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Tang J, Li B, Liu C, Li Q, Wang L, Min J, Hu M, Hong S and Hong L: Mechanism of mechanical trauma-induced extracellular matrix remodeling of fibroblasts in association with Nrf2/ARE signaling suppression mediating TGF-β1/Smad3 signaling inhibition. Oxid Med Cell Longev. 2017:85243532017. View Article : Google Scholar : PubMed/NCBI

33 

Ding Y, Zhang B, Zhou K, Chen M, Wang M, Jia Y, Song Y, Li Y and Wen A: Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: Role of Nrf2 activation. Int J Cardiol. 175:508–514. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Jin Y, Huang ZL, Li L, Yang Y, Wang CH, Wang ZT and Ji LL: Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway. Acta Pharmacol Sin. 19–Jun;2018.(Epub ahead of print). View Article : Google Scholar

35 

Zhou Y, Zhang J, Lei B, Liang W, Gong J, Zhao C, Yu J, Li X, Tang B and Yuan S: DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO1 pathway. Mol Med Rep. 16:6214–6221. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Ding Y, Chen M, Wang M, Wang M, Zhang T, Park J, Zhu Y, Guo C, Jia Y, Li Y and Wen A: Neuroprotection by acetyl-11-keto-β-Boswellic acid, in ischemic brain injury involves the Nrf2/HO-1 defense pathway. Sci Rep. 4:70022014. View Article : Google Scholar : PubMed/NCBI

37 

Lee MH, Han MH, Lee DS, Park C, Hong SH, Kim GY, Hong SH, Song KS, Choi IW, Cha HJ and Choi YH: Morin exerts cytoprotective effects against oxidative stress in C2C12 myoblasts via the upregulation of Nrf2-dependent HO-1 expression and the activation of the ERK pathway. Int J Mol Med. 39:399–406. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Qiao B, Gao F, Wang H, Miao S and Zhao H: Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway. Mol Med Rep 18: 3497-3505, 2018.
APA
Zhang, Y., Qiao, B., Gao, F., Wang, H., Miao, S., & Zhao, H. (2018). Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway. Molecular Medicine Reports, 18, 3497-3505. https://doi.org/10.3892/mmr.2018.9315
MLA
Zhang, Y., Qiao, B., Gao, F., Wang, H., Miao, S., Zhao, H."Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway". Molecular Medicine Reports 18.3 (2018): 3497-3505.
Chicago
Zhang, Y., Qiao, B., Gao, F., Wang, H., Miao, S., Zhao, H."Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway". Molecular Medicine Reports 18, no. 3 (2018): 3497-3505. https://doi.org/10.3892/mmr.2018.9315
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Qiao B, Gao F, Wang H, Miao S and Zhao H: Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway. Mol Med Rep 18: 3497-3505, 2018.
APA
Zhang, Y., Qiao, B., Gao, F., Wang, H., Miao, S., & Zhao, H. (2018). Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway. Molecular Medicine Reports, 18, 3497-3505. https://doi.org/10.3892/mmr.2018.9315
MLA
Zhang, Y., Qiao, B., Gao, F., Wang, H., Miao, S., Zhao, H."Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway". Molecular Medicine Reports 18.3 (2018): 3497-3505.
Chicago
Zhang, Y., Qiao, B., Gao, F., Wang, H., Miao, S., Zhao, H."Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway". Molecular Medicine Reports 18, no. 3 (2018): 3497-3505. https://doi.org/10.3892/mmr.2018.9315
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